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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers
期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:
Lu, Xuxiu
;
Yu, Rilei
;
Li, Zhen
;
Yang, Mengke
;
Dai, Jiajia
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/04/07
Acquired resistance
Cancer
NSCLC
JC-010a
SHP2
Insights into multidimensional transport flux from vertical observation and numerical simulation in two cities in North China
期刊论文
JOURNAL OF ENVIRONMENTAL SCIENCES, 2023, 卷号: 125
作者:
Zhang, Zhida
;
Wang, Xiaoqi
;
Cheng, Shuiyuan
;
Tang, Guiqian
;
Fu, Yibin
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2022/12/23
Transport flux
Horizontal transport
Vertical exchange
Atmospheric boundary layer
Free troposphere
Pollutant budget relationship
Estimation and characterization of the refractive index structure constant within the marine atmospheric boundary layer
期刊论文
APPLIED OPTICS, 2022, 卷号: 61
作者:
Zhang, Hanjiu
;
Zhu, Liming
;
Sun, Gang
;
Zhang, Kun
;
Xu, Manman
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  |  
浏览/下载:20/0
  |  
提交时间:2022/12/23
Distribution and transport characteristics of fine particulate matter in beijing with mobile lidar measurements from 2015 to 2018
期刊论文
JOURNAL OF ENVIRONMENTAL SCIENCES, 2022, 卷号: 115
作者:
Ding, Zecong
;
Sun, Guangzhao
;
Fu, Fenglian
;
Ye, Chujia
;
Lul, Lihui
收藏
  |  
浏览/下载:294/0
  |  
提交时间:2022/02/21
Aerosol
Regional transport
Lidar
Mobile measurement
PM2
5
Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Dong, Ying
;
Tang, Bi-xi
;
Wang, Qi
;
Zhou, Li-wei
;
Li, Cong
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  |  
浏览/下载:77/0
  |  
提交时间:2022/01/04
idiopathic pulmonary fibrosis
DDRs
kinase inhibitor
indazole derivatives
XBLJ-13
nintedanib
bleomycin-induced pulmonary fibrosismouse model
Increasing the Sampling Efficiency of Protein Conformational Change by Combining a Modified Replica Exchange Molecular Dynamics and Normal Mode Analysis
期刊论文
JOURNAL OF CHEMICAL THEORY AND COMPUTATION, 2021, 卷号: 17, 期号: 1, 页码: 13-28
作者:
Peng, Cheng
;
Wang, Jinan
;
Shi, Yulong
;
Xu, Zhijian
;
Zhu, Weiliang
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/05/24
An ultra-long circulating nanoparticle for reviving a highly selective BCR-ABL inhibitor in long-term effective and safe treatment of chronic myeloid leukemia
期刊论文
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2020, 卷号: 29
作者:
Fu, Liyi
;
Zou, Fengming
;
Liu, Qingwang
;
Wang, Beilei
;
Wang, Junqing
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  |  
浏览/下载:25/0
  |  
提交时间:2020/11/30
Chronic myeloid leukemia
BCR-ABL
Long-circulating nanoparticle
Drug delivery
Repurposing of Kinase Inhibitors for Treatment of COVID-19
期刊论文
PHARMACEUTICAL RESEARCH, 2020, 卷号: 37
作者:
Weisberg, Ellen
;
Parent, Alexander
;
Yang, Priscilla L.
;
Sattler, Martin
;
Liu, Qingsong
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  |  
浏览/下载:34/0
  |  
提交时间:2020/10/26
Coronavirus
SARS-CoV-2
SARS-CoV
MERS-CoV
kinase inhibitors
pharmacokinetics
antiviral therapy
COVID-19
Solution NMR structure and ligand identification of human Gas7 SH3 domain reveal a typical SH3 fold but a non-canonical ligand-binding mode
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 卷号: 516, 期号: 4, 页码: 1190-1195
作者:
Nie, Yao
;
Zhu, Jiang
;
Ramelot, Theresa A.
;
Kennedy, Michael A.
;
Liu, Maili
收藏
  |  
浏览/下载:79/0
  |  
提交时间:2019/10/14
Growth arrest specific 7
Src homology 3
NMR structure
Praline-rich
Phage display
Lighting device with optical lens for beam shaping and refractive segments
专利
专利号: US20190235257A1, 申请日期: 2019-08-01, 公开日期: 2019-08-01
作者:
MAO, AN
;
AGGARWAL, JANUK
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  |  
浏览/下载:5/0
  |  
提交时间:2019/12/30
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