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上海药物研究所 [22]
厦门大学 [6]
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山东大学 [4]
复旦大学上海医学院 [4]
大连化学物理研究所 [3]
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期刊论文 [74]
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CHMFL-26 is a highly potent irreversible HER2 inhibitor for use in the treatment of HER2-positive and HER2-mutant cancers
期刊论文
ACTA PHARMACOLOGICA SINICA, 2022
作者:
Cao, Jiang-yan
;
Qi, Shuang
;
Wu, Hong
;
Wang, Ao-li
;
Liu, Qing-wang
收藏
  |  
浏览/下载:92/0
  |  
提交时间:2022/03/28
HER2
breast cancers
gastric cancers
irreversible inhibitor
drug resistance
Synthesis of the analogs of plocabulin and their preliminary structure-activity relationship study
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 51, 页码: 5
作者:
Wang, Leiming
;
Li, Xin
;
Cui, Hong
;
Lei, Xinsheng
;
Liu, Hongchun
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/12/01
Marine nature products
Plocabulin
PM060184
Synthesis
Antiproliferation
A validated HPLC-MS/MS method for determination of simmitecan and its metabolite chimmitecan in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor
期刊论文
JOURNAL OF SEPARATION SCIENCE, 2021, 页码: 8
作者:
Zhou, Jun
;
Zhan, Yan
;
Zhong, Dafang
;
Chen, Xiaoyan
;
Zhang, Yifan
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  |  
浏览/下载:72/0
  |  
提交时间:2021/11/04
chimmitecan
mass spectrometry
pharmacokinetics
simmitecan
solid tumors
Hyperprins A and B, Two Complex Meroterpenoids from Hypericum przewalskii
期刊论文
ORGANIC LETTERS, 2020, 卷号: 22, 期号: 7, 页码: 2797-2800
作者:
Zong, Jian-Fa
;
Hu, Zhu
;
Shao, Ying-Ying
;
Shi, Qing
;
Zhang, Meng-Meng
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  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
Straightforward synthesis, characterization, and cytotoxicity evaluation of hybrids of natural alkaloid evodiamine/rutaecarpine and thieno[2,3-d]pyrimidinones
期刊论文
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2020, 卷号: 22, 期号: 1, 页码: 69-82
作者:
Nie, LF (Nie, Li-Fei)[ 1,2 ]
;
Wang, SS (Wang, Si-Si)[ 3 ]
;
Cao, JG (Cao, Jian-Guo)[ 3 ]
;
Liu, FZ (Liu, Fei-Ze)[ 1,2 ]
;
Xiamuxi, HBM (Xiamuxi, Hainimu)[ 1,2 ]
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  |  
浏览/下载:156/0
  |  
提交时间:2020/01/15
Thieno[2
3-d]pyrimidinone
evodiamine
rutaecarpine
hybrid
cytotoxicity
Design, Synthesis and Antiproliferative Activity of Chrysin Derivatives Bearing Triazole Moieties
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 卷号: 40, 期号: 2, 页码: 440-446
作者:
Luan Tian
;
Quan Zheshan
;
Fang Yingquan
;
Yang Hongjing
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2021/02/02
INHIBITION
CELLS
chrysin
synthesis
triazole
derivatives
antiproliferation
Identification of new NIK inhibitors by discriminatory analysis-based molecular docking and biological evaluation
期刊论文
ARCHIV DER PHARMAZIE, 2019, 卷号: 352, 期号: 7, 页码: 9
作者:
Cheng, Gang
;
Mei, Xiao-Bing
;
Yan, You-You
;
Chen, Jing
;
Zhang, Bo
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  |  
浏览/下载:9/0
  |  
提交时间:2020/07/01
antiproliferation activity
inhibitors
NF-kappa B inducing kinase
virtual screen
Cytotoxic Trichothecene Macrolides Produced by the Endophytic Myrothecium roridum
期刊论文
JOURNAL OF NATURAL PRODUCTS, 2019, 卷号: 82, 期号: 6, 页码: 1503-1509
作者:
Shen, Li
;
Ai, Chun-Zhi
;
Song, Yong-Chun
;
Wang, Feng-Wu
;
Jiao, Rui-Hua
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  |  
浏览/下载:61/0
  |  
提交时间:2019/12/02
Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 8, 页码: 3898-3923
作者:
Liang, Xuewu
;
Zang, Jie
;
Li, Xiaoyang
;
Tang, Shuai
;
Huang, Min
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  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
Discovery of Novel PRMT5 Inhibitors by Virtual Screening and Biological Evaluations
期刊论文
CHEMICAL & PHARMACEUTICAL BULLETIN, 2019, 卷号: 67, 期号: 4, 页码: 382-388
作者:
Tao, Hongrui
;
Yan, Xue
;
Zhu, Kongkai
;
Zhang, Hua
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  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
virtual screening
epigenetic inhibitor
antiproliferation
molecular docking
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