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西北高原生物研究所 [9]
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Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 177, 页码: 15
作者:
Liu, Zehui
;
Hu, Qian
;
Wang, Wanyan
;
Lu, Sisi
;
Wu, Dang
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/12/24
Multiple sclerosis
DHODH
Piperine
Natural product
leflunomideincreasedtherenalexposureofacyclovirbyinhibitingoat13andmrp2
期刊论文
actapharmacologicasinica, 2020, 卷号: 41, 期号: 1, 页码: 129
作者:
Liao Xiaoying
;
Deng Qiangqiang
;
Han Li
;
Wu Zhitao
;
Peng Zhaoliang
收藏
  |  
浏览/下载:84/0
  |  
提交时间:2020/07/01
leflunomide
teriflunomide
acyclovir
organic anion transporter
multidrug resistance associated protein (MRP) 2
drugdrug interaction
pharmacokinetics
Leflunomide increased the renal exposure of acyclovir by inhibiting OAT1/3 and MRP2
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 1, 页码: 129-137
作者:
Liao, Xiao-ying
;
Deng, Qiang-qiang
;
Han, Li
;
Wu, Zhi-tao
;
Peng, Zhao-liang
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  |  
浏览/下载:55/0
  |  
提交时间:2020/07/01
leflunomide
teriflunomide
acyclovir
organic anion transporter
multidrug resistance associated protein (MRP) 2
drug-drug interaction
pharmacokinetics
A population pharmacokinetic study to accelerate early phase clinical development for a novel drug, teriflunomide sodium, to treat systemic lupus erythematosus
期刊论文
2019, 卷号: 136, 页码: 104942
作者:
Yao, Xueting
;
Wu, Yiwen
;
Jiang, Ji
;
Chen, Xia
;
Liu, Dongyang
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/01/03
Population pharmacokinetics
Leflunomide
Teriflunomide sodium
Enterohepatic circulation
Development of a simple HPLC-MS/MS method to simultaneously determine teriflunomide and its metabolite in human plasma and urine: Application to clinical pharmacokinetic study of teriflunomide sodium and leflunomide
期刊论文
2019, 卷号: 33, 期号: 3, 页码: e4420
作者:
Yao, Xueting
;
Liu, Yang
;
Song, Ling
;
Jiang, Ji
;
Xiao, Fei
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/01/03
HPLC-MS/MS
human plasma and urine
leflunomide
pharmacokinetics
teriflunomide
Safety, Pharmacokinetics, and Pharmacogenetics of Single-Dose Teriflunomide Sodium and Leflunomide in Healthy Chinese Subjects
期刊论文
2019, 卷号: 39, 期号: 7, 页码: 643-651
作者:
Yao, Xueting
;
Wu, Yiwen
;
Jiang, Ji
;
Hu, Pei
;
Liu, Dongyang
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  |  
浏览/下载:14/0
  |  
提交时间:2020/01/03
Cost-effectiveness of Teriflunomide Compared to Interferon Beta-1b for Relapsing Multiple Sclerosis Patients in China
期刊论文
2019, 卷号: 39, 期号: 3, 页码: 331-340
作者:
Xu, Yan
;
Mao, Ningying
;
Chirikov, Viktor
;
Du, Fen
;
Yeh, Yu-Chen
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  |  
浏览/下载:7/0
  |  
提交时间:2020/01/03
In Vitro Human Dihydroorotate Dehydrogenase Inhibitory, Anti-inflammatory and Cytotoxic Activities of Alkaloids from the Seeds of Nigella glandulifera
期刊论文
PLANTA MEDICA, 2018, 卷号: 84, 期号: 14, 页码: 1013-1021
作者:
Gao, Jun-Bo
;
Zhang, Xing-Jie
;
Zhang, Rui-Han
;
Zhu, Li-Li
;
Pu, De-Bing
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  |  
浏览/下载:30/0
  |  
提交时间:2018/10/22
dolabellane-type diterpene alkaloids
Ranunculaceae
Nigella glandulifera
human dihydroorotate dehydrogenase
lipopolysaccharide
nitric oxide production
cytotoxic activity
Efficacy and Safety of Teriflunomide in Chinese Patients with Relapsing Forms of Multiple Sclerosis: A Subgroup Analysis of the Phase 3 TOWER Study
期刊论文
CHINESE MEDICAL JOURNAL, 2018, 卷号: 131, 期号: 23
作者:
Qiu, Wei
;
Huang, De-Hui
;
Hou, Shi-Fang
;
Zhang, Mei-Ni
;
Jin, Tao
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/05
Chinese Patients
Efficacy
Phase 3
Relapsing Multiple Sclerosis
Safety
Teriflunomide
TOWER
Efficacy and Safety of Teriflunomide in Chinese Patients with Relapsing Forms of Multiple Sclerosis: A Subgroup Analysis of the Phase 3 TOWER Study
期刊论文
CHINESE MEDICAL JOURNAL, 2018, 卷号: 131, 期号: 23
作者:
Qiu, Wei
;
Huang, De-Hui
;
Hou, Shi-Fang
;
Zhang, Mei-Ni
;
Jin, Tao
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/05
Chinese Patients
Efficacy
Phase 3
Relapsing Multiple Sclerosis
Safety
Teriflunomide
TOWER
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