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期刊论文 [10]
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Additive effects of variants of unknown significance in replication repair-associated DNA polymerase genes on mutational burden and prognosis across diverse cancers
期刊论文
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 卷号: 9
作者:
Ying, Jieer
;
Yang, Lin
;
Yin, Jiani C.
;
Xia, Guojie
;
Xing, Minyan
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/11/15
biomarkers
tumor
genetic markers
genome instability
Immunotherapy
translational medical research
Intrinsic Nucleotide Preference of Diversifying Base Editors Guides Antibody Ex Vivo Affinity Maturation
期刊论文
CELL REPORTS, 2018, 卷号: 25, 期号: 4, 页码: 884-+
作者:
Liu, Liu Daisy
;
Huang, Min
;
Dai, Pengfei
;
Liu, Tingting
;
Fan, Shuangshuang
收藏
  |  
浏览/下载:78/0
  |  
提交时间:2019/04/28
Induced Cytidine Deaminase
Class Switch Recombination
Somatic Hypermutation
Neutralizing Antibodies
Genomic Instability
Eukaryotic Genomes
Structural Basis
Mammalian-cells
Super-enhancers
Dna Cleavage
The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes
期刊论文
CELL RESEARCH, 2018, 卷号: 28, 期号: 10, 页码: 981-995
作者:
Chen, Juan
;
Cai, Zhaokui
;
Yu, Xiaohua
;
Cao, Changchang
;
Hu, Xihao
收藏
  |  
浏览/下载:110/0
  |  
提交时间:2019/04/28
Induced Cytidine Deaminase
Single-stranded-dna
One-step Generation
Center B-cells
Non-ig Genes
Somatic Hypermutation
Sequencing Reveals
Super-enhancers
Read Alignment
Recruit Aid
Therapeutic effects of the artemisinin analog SM934 on lupus-prone MRL/lpr mice via inhibition of TLR-triggered B-cell activation and plasma cell formation
期刊论文
CELLULAR & MOLECULAR IMMUNOLOGY, 2016, 卷号: 13, 期号: 3, 页码: 379-390
作者:
Wu, Yanwei
;
He, Shijun
;
Bai, Bingxin
;
Zhang, Luyao
;
Xue, Lu
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  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
B cell
plasma cell
SM934
systemic lupus erythematosus
Toll-like receptor
Epigenetic dynamics in immunity and autoimmunity
期刊论文
The International Journal of Biochemistry & Cell Biology, 2015, 卷号: 67, 页码: 65-74
作者:
Zhao, Ming
;
Wang, Zijun
;
Yung, Susan
;
Lu, Qianjin*
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/12/03
Epigenetic dynamics
Immune system
Autoimmune diseases
DNA methylation
Histone modifications
DNMT
DNA methyltransferase
TET
ten-eleven translocation
AID/AICDA
activation-induced cytidine deaminase
APOBEC
Apolipoprotein B mRNA editing enzyme
BER
base excision repair
MBD4
methyl-CpG binding domain protein 4
HATs
histone acetyltransferases
HDAC
histone deacetylase
HMT
histone methyltransferase
5mC
5-methylcytosine
5hmC
5-hydroxymethylcytosine
GC
germinal center
DC
dendritic cell
SHM
somatic hypermutation
CSR
class switch recombination
Blimp-1
B lymphocyte-induced maturation protein-1
Treg
regulatory T
NFAT
nuclear factor of activated T-cells
TSDR
Treg-specific demethylated region
PDCD1
programmed cell death 1
Prf1
Perforin
Gzmb
Granzyme B
CTL
cytotoxic T cell
EBF1
early B cell factor1
Pax5
Paired box protein
TSA
Trichostatin A
SLE
systemic lupus erythematosus
RA
rheumatoid arthritis
MS
multiple sclerosis
T1D
type 1 diabetes mellitus
ERK
extracellular regulated protein kinases
PBMC
peripheral blood mononuclear cell
PAD2
peptidylarginine deiminase 2
IGFBP-1
insulin-like growth factor-binding protein 1
LPS
lipopolysaccharide
Expansion and Somatic Hypermutation of B-cell Clones in Rejected Human Kidney Grafts
期刊论文
TRANSPLANTATION, 2014, 卷号: 98, 期号: 7
作者:
Ferdman, Jack
;
Porcheray, Fabrice
;
Gao, Baoshan
;
Moore, Carolina
;
DeVito, Julie
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/05
Infiltrating B cells
Graft rejection
Kidney allografts
Sequence variability of fibrinogen-related proteins (FREPs) in Crassostrea gigas
期刊论文
CHINESE SCIENCE BULLETIN, 2012, 卷号: 57, 期号: 25, 页码: 3312-3319
作者:
Zhang LinLin
;
Li Li
;
Zhang GuoFan
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2013/09/24
Crassostrea gigas
FREPs
fibrinogen-related proteins
recombination
oysters
Affinity maturation of anti-TNF-alpha scFv with somatic hypermutation in non-B cells
期刊论文
PROTEIN & CELL, 2012, 卷号: 3, 期号: 6, 页码: 460-469
Chen, Shaopeng
;
Qiu, Junkang
;
Chen, Chuan
;
liu, chunchun
;
刘春春
;
Liu, Yuheng
;
An, Lili
;
jia, junying
;
贾俊英
;
Tang, Jie
;
唐捷
;
Wu, Lijun
;
Hang, Haiying
;
杭海英
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2013/12/24
antibody
activation-induced cytidine deaminase (AID)
somatic hypermutation
affinity maturation
TNF-alpha
R-loop-mediated genomic instability is caused by impairment of replication fork progression
期刊论文
genes development, 2011
Gan, Wenjian
;
Guan, Zhishuang
;
Liu, Jie
;
Gui, Ting
;
Shen, Keng
;
Manley, James L.
;
Li, Xialu
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2015/11/13
R loop
genome stability
transcription
replication
CLASS-SWITCH RECOMBINATION
DNA TOPOISOMERASE-I
TRANSCRIPTION-ASSOCIATED RECOMBINATION
RIBOSOMAL-RNA SYNTHESIS
CYTIDINE DEAMINASE AID
ESCHERICHIA-COLI
ANTIBODY DIVERSIFICATION
HOMOLOGOUS RECOMBINATION
SOMATIC HYPERMUTATION
GEL-ELECTROPHORESIS
Characterization of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) in Shanghai, China: Molecular and cytogenetic characteristics, IgV gene restriction and hypermutation patterns
期刊论文
LEUKEMIA RESEARCH, 2009, 卷号: 33, 期号: 12
作者:
Irons, Richard D.
;
Le, Anh
;
Bao, Liming
;
Zhu, Xiongzeng
;
Ryder, John
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/19
Chronic lymphocytic leukemia
Small lymphocytic lymphoma
Cytogenetics
Fluorescence in situ hybridization
IgV genes
Somatic hypermutation
14q32/IGH
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