CORC

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CORC

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Identification of methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) as an orally bioavailable, highly potent, PI3K alpha inhibitor for the treatment of advanced solid tumors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 209, 页码: 10
作者:  Xiang, Hao-Yue;  Wang, Xiang;  Chen, Yan-Hong;  Zhang, Xi;  Tan, Cun
收藏  |  浏览/下载：34/0  |  提交时间：2021/05/24
Emerging roles of class I PI3K inhibitors in modulating tumor microenvironment and immunity 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 8
作者:  Sun, Pu;  Meng, Ling-hua
收藏  |  浏览/下载：39/0  |  提交时间：2020/12/21
Design, synthesis, and biological evaluation of thieno[3,2-d]pyrimidine derivatives as potential simplified phosphatidylinositol 3-kinase alpha inhibitors 期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 卷号: 94, 期号: 6, 页码: 2013-2022
作者:  Yang, Xiuyan;  Deng, Meng;  Zhang, Xi;  Wang, Yi;  Song, Kun
收藏  |  浏览/下载：75/0  |  提交时间：2020/07/01
High-throughput screening campaigns against a PI3K alpha isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds 期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 11, 页码: 1816-1822
作者:  Wang, Jia;  Gong, Grace Qun;  Zhou, Yan;  Lee, Woo-Jeong;  Buchanan, Christina Maree
收藏  |  浏览/下载：84/0  |  提交时间：2019/01/08
Synthesis, biological evaluation and structure-activity relationship of a novel class of PI3K alpha H1047R mutant inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 707-719
作者:  Zhang, Ning;  Yu, Zhimei;  Yang, Xiaohong;  Zhou, Yan;  Wang, Jia
收藏  |  浏览/下载：85/0  |  提交时间：2019/01/08
High-throughput screening campaigns against a PI3K alpha isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds 期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 11
作者:  Wang, Jia;  Gong, Grace Qun;  Zhou, Yan;  Lee, Woo-Jeong;  Buchanan, Christina Maree
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/05
Discovery of novel quinazolinone derivatives as high potent and selective PI3Kδ and PI3Kδ/γ inhibitors 期刊论文
European Journal of Medicinal Chemistry, 2018, 卷号: 151, 页码: 9-17
作者:  Ma C.-C.;  Zhang C.-M.;  Tang L.-Q.;  Liu Z.-P.
收藏  |  浏览/下载：2/0  |  提交时间：2019/12/11
Discovery of novel quinazolinone derivatives as high potent and selective PI3K delta and PI3K delta/gamma inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 151, 页码: 9-17
作者:  Ma, Chen-Chen;  Zhang, Cheng-Mei;  Tang, Long-Qian;  Liu, Zhao-Peng
收藏  |  浏览/下载：17/0  |  提交时间：2019/12/11
Combined inhibition of PI3K delta and FLT3 signaling exerts synergistic antitumor activity and overcomes acquired drug resistance in FLT3-activated acute myeloid leukemia 期刊论文
CANCER LETTERS, 2018, 卷号: 420, 页码: 49-59
作者:  He, Ye;  Sun, Liping;  Xu, Yongping;  Fu, Li;  Li, Yun
收藏  |  浏览/下载：34/0  |  提交时间：2019/01/08
highthroughputscreeningcampaignsagainstapi3kisoformbearingtheh1047rmutationidentifiedpotentialinhibitorswithnovelscaffolds 期刊论文
actapharmacologicasinica, 2018, 卷号: 039, 期号: 011, 页码: 1816
作者:  Wang Jia;  Gong Grace Qun;  Zhou Yan;  Lee Woojeong;  Buchanan Christina Maree
收藏  |  浏览/下载：9/0  |  提交时间：2020/07/01

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