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大连化学物理研究所 [21]
上海药物研究所 [19]
厦门大学 [7]
武汉大学 [7]
复旦大学上海医学院 [6]
山东大学 [5]
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期刊论文 [97]
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Crosstalk between CYP2E1 and PPAR alpha substrates and agonists modulate adipose browning and obesity
期刊论文
ACTA PHARMACEUTICA SINICA B, 2022, 卷号: 12, 期号: 5, 页码: 2224-2238
作者:
Zhang, Youbo
;
Yan, Tingting
;
Wang, Tianxia
;
Liu, Xiaoyan
;
Hamada, Keisuke
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/07/19
CYP2E1
PPAR alpha
FGF21
Metabolic enzyme
Nuclear receptor
Obesity
Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity
期刊论文
XENOBIOTICA, 2021, 页码: 13
作者:
Sun, Dongxue
;
Gao, Xiaoxia
;
Wang, Qiao
;
Krausz, Kristopher W.
;
Fang, Zhongze
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2021/11/04
CYP
podophyllotoxin metabolism
liver microsomes
recombinant drug-metabolizing enzymes
hepatic and intestinal toxicity
Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 7, 页码: 1885-1902
作者:
Wu, Xu
;
Yin, Chun
;
Ma, Jiang
;
Chai, Stella
;
Zhang, Chunyuan
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/11/04
Multidrug resistance
ABCB1
Polyoxypregnane
Combination chemotherapy
Marsdenia tenacissima
Furmonertinib (Alflutinib, AST2818) is a potential positive control drug comparable to rifampin for evaluation of CYP3A4 induction in sandwich-cultured primary human hepatocytes
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Wu, Ya-li
;
Xue, Ya-ru
;
Guo, Zi-tao
;
Chen, Zhen-dong
;
Ge, Xin-yu
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/08/17
furmonertinib (alflutinib
AST2818)
quantitative proteomics
sandwich-cultured human hepatocytes
Pharmacokinetic Drug-drug Interaction of Antibiotics Used in Sepsis Care in China
期刊论文
CURRENT DRUG METABOLISM, 2021, 卷号: 22, 期号: 1, 页码: 5-23
作者:
Yu, Xuan
;
Chu, Zixuan
;
Li, Jian
;
He, Rongrong
;
Wang, Yaya
收藏
  |  
浏览/下载:67/0
  |  
提交时间:2021/05/24
Pharmacokinetics
drug-drug interaction
antibiotic
sepsis
transporter
enzyme
Metagenomic studies of SAR202 bacteria at the full-ocean depth in the Mariana Trench
期刊论文
Deep-Sea Research Part I, 2020, 卷号: 165, 期号: 103396, 页码: 9
作者:
Zhan-Fei Wei
;
Wen-Li Li
;
JiaMei Huang
;
Yong Wang
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2020/12/23
Deep-sea
SAR202
Metagenome
Metabolic capacities
Microbial community
Inhibition of phosphatidylinositol kinase-III alpha induces or facilitates lysosome exocytosis from microglia.
期刊论文
NEUROREPORT, 2020, 卷号: 31, 期号: 10, 页码: 697-701
作者:
Mu, Shujing
;
Lim, Nastasia K. -H.
;
Huang, Fude
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  |  
浏览/下载:11/0
  |  
提交时间:2020/12/24
exocytosis
lysosome
microglia
phosphatidylinositols
Current trends in drug metabolism and pharmacokinetics
期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 6, 页码: 1113-1144
作者:
Li, Yuhua
;
Meng, Qiang
;
Yang, Mengbi
;
Liu, Dongyang
;
Hou, Xiangyu
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/01
Pharmacokinetics
Drug metabolism
Drug-drug interactions
Modeling
Metabolizing enzymes
Transporters
Nuclear receptors
Noncoding RNAs
High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care
期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 5, 页码: 1035-1049
作者:
Li, Jian
;
Olaleye, Olajide E.
;
Yu, Xuan
;
Jia, Weiwei
;
Yang, Junling
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
XueBiJing
Antibiotic
Combination drug therapy
Sepsis
Pharmacokinetic compatibility
Herb-drug interaction
Cytochrome P450 3A Enzymes Are Key Contributors for Hepatic Metabolism of Bufotalin, a Natural Constitute in Chinese Medicine Chansu
期刊论文
FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10, 页码: 10
作者:
Ma, Hong-Ping
;
Dai, Zi-Ru
;
Ning, Jing
;
Sun, Gui-Bo
;
Wang, Ping
收藏
  |  
浏览/下载:65/0
  |  
提交时间:2019/06/20
bufotalin
cytochrome P450 3A (CYP3A)
hydroxylation
human liver microsomes (HLMs)
docking simulations
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