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上海药物研究所 [49]
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期刊论文 [89]
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Idarubicin Stimulates Cell Cycle- and TET2-Dependent Oxidation of DNA 5-Methylcytosine in Cancer Cells
期刊论文
CHEMICAL RESEARCH IN TOXICOLOGY, 2019, 卷号: 32, 期号: 5, 页码: 861-868
作者:
Zhong, Shangwei
;
Li, Cuiping
;
Han, Xiao
;
Li, Xiangjun
;
Yang, Yun-Gui
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/10/21
Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 6, 页码: 2950-2973
作者:
Shi, Chenghui
;
Zhang, Yinyong
;
Wang, Ting
;
Lu, Wenchao
;
Zhang, Shuhua
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/07/01
Synthesis and In Vitro Antitumor Activity of Novel Bivalent -Carboline-3-carboxylic Acid Derivatives with DNA as a Potential Target
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 卷号: 19, 期号: 10
作者:
Gu, Hongling
;
Li, Na
;
Dai, Jiangkun
;
Xi, Yaxi
;
Wang, Shijun
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
bivalent -carbolines
antitumor
apoptosis
DNA-binding affinity
bcl-2
New tanshinone I derivatives S222 and S439 similarly inhibit topoisomerase I/II but reveal different p53-dependency in inducing G2/M arrest and apoptosis
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2018, 卷号: 154, 页码: 255-264
作者:
Tian, Qian-Ting
;
Ding, Chun-Yong
;
Song, Shan-Shan
;
Wang, Ying-Qing
;
Zhang, Ao
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  |  
浏览/下载:40/0
  |  
提交时间:2019/01/08
Tanshinone-1
S222
S439
Anticancer targets
DNA topoisomerases
P53
Discovery of Novel Topoisomerase II Inhibitors by Medicinal Chemistry Approaches.
期刊论文
Journal of Medicinal Chemistry, 2018, 期号: ~, 页码: ~
作者:
Wei Hu
;
Yue-Mao Shen
;
Zhi-Yu Li
;
Xun Li
;
Yong-Tang Zheng
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2018/09/20
Type IA topoisomerases can be "magicians" for both DNA and RNA in all domains of life
期刊论文
RNA BIOLOGY, 2017
Ahmad, Muzammil
;
Xu, Dongyi
;
Wang, Weidong
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2017/12/03
FMRP
polyribosomes
topoisomerase
TDRD3
Top3
Top3
BLOOM-SYNDROME DISSOLVASOME
X-SYNDROME PROTEIN
ESCHERICHIA-COLI
MESSENGER-RNA
III-ALPHA
ESSENTIAL COMPONENT
CELLULAR ROLES
CIRCULAR RNAS
COMPLEX
TDRD3
Synthesis and biological research of novel azaacridine derivatives as potent DNA-binding ligands and topoisomerase II inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 卷号: 25, 页码: 3437-3446
作者:
Li, Dan[1,2,3]
;
Yuan, Zigao[1,2,3]
;
Chen, Shaopeng[2,3]
;
Zhang, Cunlong[3]
;
Song, Lu[1,2,3]
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/04/24
Azaacridine derivatives
Molecular docking
DNA binding
Topoisomerase II inhibitor
Antiproliferative activity
Synthesis and antiproliferative activity of 9-benzylamino-6-chloro-2-methoxy-acridine derivatives as potent DNA-binding ligands and topoisomerase II inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 116, 页码: 59-70
作者:
Zhang, Wei[1,2,3]
;
Zhang, Bin[3]
;
Zhang, Wei[1,2,3]
;
Yang, Ti[1]
;
Wang, Ning[1,2]
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/04/24
Acridine derivatives
Topoisomerase II inhibitor
Antiproliferative activity
DNA damage
Dual targeting of microtubule and topoisomerase II by alpha-carboline derivative YCH337 for tumor proliferation and growth inhibition
期刊论文
ONCOTARGET, 2015, 卷号: 6, 期号: 11, 页码: 8960-8973
作者:
Yi, Jun-Mei
;
Zhang, Xiao-Fei
;
Huan, Xia-Juan
;
Song, Shan-Shan
;
Wang, Wei
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
YCH337
alpha-carboline derivative
microtubule
topoisomerase II
antitumor activity
Design, Synthesis, and Cytotoxicity of Perbutyrylated Glycosides of 4 beta-Triazolopodophyllotoxin Derivatives
期刊论文
MOLECULES, 2015, 卷号: 20, 期号: 2, 页码: 3255-3280
作者:
Zi, Cheng-Ting
;
Liu, Zhen-Hua
;
Li, Gen-Tao
;
Li, Yan
;
Zhou, Jun
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2015/06/29
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