Type IA topoisomerases can be &quot;magicians&quot; for both DNA and RNA in all   domains of life

doi:10.1080/15476286.2017.1330741

CORC > 北京大学 > 生命科学学院

	Type IA topoisomerases can be "magicians" for both DNA and RNA in all domains of life
	Ahmad, Muzammil ; Xu, Dongyi ; Wang, Weidong
刊名	RNA BIOLOGY
	2017
关键词	FMRP polyribosomes topoisomerase TDRD3 Top3 Top3 BLOOM-SYNDROME DISSOLVASOME X-SYNDROME PROTEIN ESCHERICHIA-COLI MESSENGER-RNA III-ALPHA ESSENTIAL COMPONENT CELLULAR ROLES CIRCULAR RNAS COMPLEX TDRD3
DOI	10.1080/15476286.2017.1330741
英文摘要	Topoisomerases solve critical topological problems in DNA metabolism and have long been regarded as the magicians of the DNA world. Here we present views from 2 of our recent studies indicating that Type IA topoisomerases from all domains of life often possess dual topoisomerase activities for both DNA and RNA. In animals, one of the 2 Type IA topoisomerases, Top3, contains an RNA-binding domain, possesses RNA topoisomerase activity, binds mRNAs, interacts with mRNA-binding proteins, and associates with active mRNA translation machinery. The RNA-binding domain is required for Top3 to bind mRNAs and promote normal neurodevelopment. Top3 forms a highly conserved complex with Tudor-domain-containing 3 (TDRD3), a protein known to interact with translation factors, histones, RNA polymerase II, single stranded DNA and RNA. Top3 requires TDRD3 for its association with the mRNA translation machinery. We suggest that Type IA topoisomerases can be magicians for not only DNA, but also RNA; and they may solve topological problems for both nucleic acids in all domains of life. In animals, Top3-TDRD3 is a dual-activity topoisomerase complex that can act on DNA to stimulate transcription, and on mRNA to promote translation.; Intramural Research Program of the National Institute on Aging, National Institutes of Health [Z01 AG000657-08]; National Basic Research Program of China [2013CB911002]; National Natural Science Foundation of China [31661143040]; SCI(E); ARTICLE; 7; 854-864; 14
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/475885]
专题	生命科学学院
推荐引用方式 GB/T 7714	Ahmad, Muzammil,Xu, Dongyi,Wang, Weidong. Type IA topoisomerases can be "magicians" for both DNA and RNA in all domains of life[J]. RNA BIOLOGY,2017.
APA	Ahmad, Muzammil,Xu, Dongyi,&Wang, Weidong.(2017).Type IA topoisomerases can be "magicians" for both DNA and RNA in all domains of life.RNA BIOLOGY.
MLA	Ahmad, Muzammil,et al."Type IA topoisomerases can be "magicians" for both DNA and RNA in all domains of life".RNA BIOLOGY (2017).