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Design, synthesis and biological evaluation of sulfonamides inhibitors of XPO1 displaying activity against multiple myeloma cells
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 235
作者:
Qu, Bingxue
;
Xu, Yongjin
;
Lu, Yang
;
Zhuang, Weihao
;
Jin, Xinxin
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2022/12/23
XPO1
Multiple myeloma
MM.1S
N-phenylsulfonamide
Oral administration
Effect of Hypoxia on Photosystem II of Tropical Seagrass Enhalus acoroides in the Dark
期刊论文
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2021, 页码: 8
作者:
Che, Xingkai
;
Zhang, Tie
;
Li, Hu
;
Zhang, Litao
;
Liu, Jianguo
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浏览/下载:38/0
  |  
提交时间:2022/01/05
Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 15, 页码: 7264-7288
作者:
Dong, Xiaowu
;
Zhan, Wenhu
;
Zhao, Mengting
;
Che, Jinxin
;
Dai, Xiaoyang
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  |  
浏览/下载:29/0
  |  
提交时间:2020/07/01
Acetyl-macrocalin B suppresses tumor growth in esophageal squamous cell carcinoma and exhibits synergistic anti-cancer effects with the Chk1/2 inhibitor AZD7762
期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019, 卷号: 365, 页码: 71-83
作者:
Wang, Jing-Nan
;
Che, Yun
;
Yuan, Zu-Yang
;
Lu, Zhi-Liang
;
Li, Yuan
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  |  
浏览/下载:76/0
  |  
提交时间:2019/03/18
Acetyl-macrocalin B
Reactive oxygen species
p38 MAPK
Chk1/Chk2
Esophageal squamous cell carcinoma
Covalent docking modelling-based discovery of tripeptidyl epoxyketone proteasome inhibitors composed of aliphatic-heterocycles
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 164, 页码: 602-614
作者:
Dong, Xiao-Wu
;
Zhang, Jian-Kang
;
Xu, Lei
;
Che, Jin-Xin
;
Cheng, Gang
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  |  
浏览/下载:35/0
  |  
提交时间:2020/07/01
Proteasome inhibitors
Tripeptide
Covalent docking
Interaction mode
The Influence of Cellulosic Polymer's Variables on Dissolution/Solubility of Amorphous Felodipine and Crystallization Inhibition from a Supersaturated State
期刊论文
AAPS PHARMSCITECH, 2019, 卷号: 20
作者:
Shi, Nian-Qiu
;
Jin, Ying
;
Zhang, Yong
;
Che, Xiao-Xia
;
Xiao, Xiao
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  |  
浏览/下载:84/0
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提交时间:2019/11/19
amorphous drug
supersaturated state
crystallization inhibition
dissolution
solubility enhancement
cellulosic polymers
MEK inhibition suppresses K-Ras wild-type cholangiocarcinoma in vitro and in vivo via inhibiting cell proliferation and modulating tumor microenvironment.
期刊论文
Cell death & disease, 2019, 卷号: 10, 页码: 120
作者:
Wang Pan
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浏览/下载:25/0
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提交时间:2019/11/19
Signal transducer and activator of transcription 3 inhibition enhances vemurafenib sensitivity in colon cancers harboring the BRAF mutation
期刊论文
Journal of Cellular Biochemistry, 2019, 卷号: Vol.120 No.4, 页码: 5315-5325
作者:
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  |  
浏览/下载:7/0
  |  
提交时间:2019/12/17
apoptosis
colon
cancer
proliferation
signal
transducer
and
activator
of
transcription
3
vemurafenib
Molecular insights into the mechanism of 4-hydroxyphenylpyruvate dioxygenase inhibition: enzyme kinetics, X-ray crystallography and computational simulations
期刊论文
The FEBS journal, 2019, 卷号: 286, 期号: 5, 页码: 975-990
作者:
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  |  
浏览/下载:18/0
  |  
提交时间:2019/12/23
4-hydroxyphenylpyruvate dioxygenase
X-ray crystallography
computational simulations
herbicide
inhibition kinetics
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 12, 页码: 3117-3125
作者:
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浏览/下载:37/0
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提交时间:2019/01/08
Depression
Cognitive impairment
Multitarget-directed ligand
5-HT1A agonist
5-HT reuptake inhibition
ChE inhibition
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