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Crosstalk between CYP2E1 and PPAR alpha substrates and agonists modulate adipose browning and obesity
期刊论文
ACTA PHARMACEUTICA SINICA B, 2022, 卷号: 12, 期号: 5, 页码: 2224-2238
作者:
Zhang, Youbo
;
Yan, Tingting
;
Wang, Tianxia
;
Liu, Xiaoyan
;
Hamada, Keisuke
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/07/19
CYP2E1
PPAR alpha
FGF21
Metabolic enzyme
Nuclear receptor
Obesity
iTRAQ-Based Quantitative Proteomic Analysis Reveals Toxicity Mechanisms in Chlamys farreri Exposed to Okadaic Acid
期刊论文
FRONTIERS IN MARINE SCIENCE, 2021, 卷号: 8, 页码: 12
作者:
Wang, Xin
;
Wang, Dan
;
Zhang, Tianyu
;
Zhang, Qianqian
;
Zhao, Jianmin
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2022/08/13
okadaic acid
Chlamys farreri
oxidative stress
detoxification genes
iTRAQ
Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity
期刊论文
XENOBIOTICA, 2021, 页码: 13
作者:
Sun, Dongxue
;
Gao, Xiaoxia
;
Wang, Qiao
;
Krausz, Kristopher W.
;
Fang, Zhongze
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2021/11/04
CYP
podophyllotoxin metabolism
liver microsomes
recombinant drug-metabolizing enzymes
hepatic and intestinal toxicity
Furmonertinib (Alflutinib, AST2818) is a potential positive control drug comparable to rifampin for evaluation of CYP3A4 induction in sandwich-cultured primary human hepatocytes
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Wu, Ya-li
;
Xue, Ya-ru
;
Guo, Zi-tao
;
Chen, Zhen-dong
;
Ge, Xin-yu
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/08/17
furmonertinib (alflutinib
AST2818)
quantitative proteomics
sandwich-cultured human hepatocytes
Functional Proliferating Human Hepatocytes: In Vitro Hepatocyte Model for Drug Metabolism, Excretion, and Toxicity
期刊论文
DRUG METABOLISM AND DISPOSITION, 2021, 卷号: 49, 期号: 4, 页码: 305-313
作者:
Qiao, Shida
;
Feng, Sisi
;
Wu, Zhitao
;
He, Ting
;
Ma, Chen
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/05/24
Pharmacokinetic Drug-drug Interaction of Antibiotics Used in Sepsis Care in China
期刊论文
CURRENT DRUG METABOLISM, 2021, 卷号: 22, 期号: 1, 页码: 5-23
作者:
Yu, Xuan
;
Chu, Zixuan
;
Li, Jian
;
He, Rongrong
;
Wang, Yaya
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2021/05/24
Pharmacokinetics
drug-drug interaction
antibiotic
sepsis
transporter
enzyme
Enrichment of imidacloprid and its metabolites in lizards and its toxic effects on gonads
期刊论文
ENVIRONMENTAL POLLUTION, 2020, 卷号: 258, 页码: 1-10
作者:
Yang, Lu
;
Shen, Qiuxuan
;
Zeng, Tao
;
Li, Jianzhong
;
Li, Wei
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2021/09/15
Lizards
Neonicotinoids
Endocrine disruption
Imidacloprid
Chemical Components and Hepatoprotective Mechanism of Xwak Granule in Mice Treated with Acute Alcohol
期刊论文
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2020, 卷号: 2020, 期号: 9, 页码: 1-13
作者:
Chen, L (Chen, Li)[ 1,2 ]
;
Liu, L (Liu, Liu)[ 1 ]
;
Abdulla, R (Abdulla, Rahima)[ 1 ]
;
Tursun, X (Tursun, Xirali)[ 1,2 ]
;
Xin, XL (Xin, Xuelei)[ 1 ]
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2020/12/07
Highlights to phytosterols accumulation and equilibrium in plants: Biosynthetic pathway and feedback regulation
期刊论文
PLANT PHYSIOLOGY AND BIOCHEMISTRY, 2020, 卷号: 155, 页码: 637-649
作者:
Zhang, Xuan
;
Lin, Kangqi
;
Li, Yinxin
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2022/03/01
Phytosterols biosynthesis
Phytosterols conversion
Sterol equilibrium
Feedback regulation
Plasma membrane remodeling
Structural basis for plant lutein biosynthesis from alpha-carotene
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 卷号: 117, 期号: 25, 页码: 14150-14157
作者:
Niu, Guoqi
;
Guo, Qi
;
Wang, Jia
;
Zhao, Shun
;
He, Yikun
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2022/03/01
xanthophyll
P450
hydroxylation
chirality
stereospecificity
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