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浏览/检索结果: 共7条，第1-7条 帮助 已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Clopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling H2S biomedicine 期刊论文 NATURE COMMUNICATIONS, 2018, 卷号: 9 作者:  Zhu, Yaoqiu;  Romero, Elkin L.;  Ren, Xiaodong;  Sanda, Angel J.;  Du, Congkuo 收藏  |  浏览/下载：20/0  |  提交时间：2019/01/08 Arylacetamide Deacetylase Is Involved in Vicagrel Bioactivation in Humans 期刊论文 FRONTIERS IN PHARMACOLOGY, 2017, 卷号: 8 作者:  Jiang, Jinfang;  Chen, Xiaoyan;  Zhong, Dafang 收藏  |  浏览/下载：32/0  |  提交时间：2019/01/08 arylacetamide deacetylase  vicagrel  clopidogrel  hydrolytic metabolism   Human Liver Cytochrome P450 Enzymes and Microsomal Thiol Methyltransferase Are Involved in the Stereoselective Formation and Methylation of the Pharmacologically Active Metabolite of Clopidogrel 期刊论文 DRUG METABOLISM AND DISPOSITION, 2015, 卷号: 43, 期号: 10, 页码: 1632-1641 作者:  Liu, Cai;  Chen, Zhaoqiang;  Zhong, Kan;  Li, Liang;  Zhu, Weiliang 收藏  |  浏览/下载：27/0  |  提交时间：2019/01/08 In Vitro Biotransformation Studies of 2-Oxo-clopidogrel: Multiple Thiolactone Ring-Opening Pathways Further Attenuate Prodrug Activation 期刊论文 毒物学领域的化学研究, 2013 Zhu, Yaoqiu; Zhou, Jiang 收藏  |  浏览/下载：2/0  |  提交时间：2015/11/13 CLOPIDOGREL BIOACTIVATION  ACTIVE METABOLITE  IDENTIFICATION  TICLOPIDINE  RESISTANCE  PRASUGREL  THIENOPYRIDINE  DISPOSITION  INVOLVEMENT  GLUTATHIONE   Deuterated Clopidogrel Analogues as a New Generation of Antiplatelet Agents 期刊论文 acs medicinal chemistry letters, 2013 Zhu, Yaoqiu; Zhou, Jiang; Jiao, Bo 收藏  |  浏览/下载：5/0  |  提交时间：2015/11/11 Clopidogrel resistance  clinical variability  prodrug attrition  piperidine deuteration  targeted metabolic shift  bioactivation potentiation  ADENOSINE DIPHOSPHATE  ACTIVE METABOLITE  BIOACTIVATION  RESISTANCE  IDENTIFICATION  AGGREGATION  INVOLVEMENT  TICLOPIDINE  PREVENTION  MECHANISM   Deuterated Clopidogrel Analogues as a New Generation of Antiplatelet Agents 期刊论文 ACS medicinal chemistry letters, 2013, 卷号: 4, 期号: 3, 页码: 349-352 作者:  Yaoqiu Zhu;  Jiang Zhou;  Bo Jiao 收藏  |  浏览/下载：2/0  |  提交时间：2019/12/23 Clopidogrel resistance  clinical variability  prodrug attrition  piperidine deuteration  targeted metabolic shift  bioactivation potentiation   Identification of the Significant Involvement and Mechanistic Role of CYP3A4/5 in Clopidogrel Bioactivation 期刊论文 acs medicinal chemistry letters, 2012 Zhu, Yaoqiu; Zhou, Jiang 收藏  |  浏览/下载：4/0  |  提交时间：2015/11/11 Clopidogrel resistance  prodrug attrition  CYP3A4/5  active metabolite potentiation  piperidine metabolism  ANTIPLATELET TREATMENT  RESPONSE VARIABILITY  PLATELET REACTIVITY  CLINICAL-EFFICACY  CYP2C19 GENOTYPE  CYTOCHROMES P450  HIGHLY POTENT  IN-VITRO  METABOLISM  RISK