×
验证码:
换一张
忘记密码?
记住我
CORC
首页
科研机构
检索
知识图谱
申请加入
托管服务
登录
注册
在结果中检索
科研机构
清华大学 [10]
长春应用化学研究所 [4]
化学研究所 [3]
上海药物研究所 [3]
大连化学物理研究所 [3]
山东大学 [3]
更多...
内容类型
期刊论文 [40]
会议论文 [1]
发表日期
2019 [6]
2018 [1]
2016 [3]
2015 [1]
2014 [2]
2013 [1]
更多...
学科主题
物理化学 [2]
Chemistry,... [1]
×
知识图谱
CORC
开始提交
已提交作品
待认领作品
已认领作品
未提交全文
收藏管理
QQ客服
官方微博
反馈留言
浏览/检索结果:
共41条,第1-10条
帮助
已选(
0
)
清除
条数/页:
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
排序方式:
请选择
作者升序
作者降序
题名升序
题名降序
发表日期升序
发表日期降序
提交时间升序
提交时间降序
Determining the protective effects of Yin-Chen-Hao Tang against acute liver injury induced by carbon tetrachloride using 16S rRNA gene sequencing and LC/MS-based metabolomics
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 174, 页码: 567-577
作者:
Liu, Fang
;
Sun, Zhaolin
;
Hu, Pei
;
Tian, Qiang
;
Xu, Zhou
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
Yin-Chen-Hao Tang
Liver injury
Metabolomics
Gut microbiota
LC-MS
Gene sequencing
Assay development for determination of DZ2002, a new reversible SAHH inhibitor, and its acid metabolite DZA in blood and application to rat pharmacokinetic study
期刊论文
JOURNAL OF PHARMACEUTICAL ANALYSIS, 2019, 卷号: 9, 期号: 1, 页码: 25-33
作者:
Jia, Weiwei
;
Li, Jing
;
Du, Feifei
;
Sun, Yan
;
Xu, Fang
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/07/01
S-adenosyl-L-homocysteine hydrolase
DZ2002
Carboxylesterases
Pharmacokinetics
Metabolomics Characterizes the Effects and Mechanisms of Quercetin in Nonalcoholic Fatty Liver Disease Development
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 卷号: 20, 期号: 5
作者:
Xu, Yan
;
Han, Jichun
;
Dong, Jinjin
;
Fan, Xiangcheng
;
Cai, Yuanyuan
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2019/11/26
nonalcoholic fatty liver disease
high fat-sucrose diet
metabolomics
HPLC-QTOF-MS
quercetin
Beta-hydroxybutyric acid attenuates neuronal damage in epileptic mice
期刊论文
ACTA HISTOCHEMICA, 2019, 卷号: 121, 期号: 4, 页码: 455-459
作者:
Guo, Qinghui
;
Liu, Shangming
;
Wang, Shandan
;
Wu, Meiyan
;
Li, Zhaoxia
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/12/11
beta-Hydroxybutyric acid
Epilepsy
Apoptosis
Oxidative stress
AMPK
PPAR alpha
Pharmacometabolomic prediction of individual differences of gastrointestinal toxicity complicating myelosuppression in rats induced by irinotecan.
期刊论文
Acta pharmaceutica Sinica. B, 2019, 卷号: No.1, 页码: 157-166
作者:
Yiqiao Gao
;
Wei Li
;
Jiaqing Chen
;
Xu Wang
;
Yingtong Lv
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2019/12/17
AUC-ROC,
area
under
receiver
operating
characteristic
BHB,
β-hydroxybutyric
acid
Biomarkers
C,
control
group
CA,
cholic
acid
CPT-11,
irinotecan
Complicating
toxicity
DBIL,
direct
bilirubin
DCA,
deoxycholic
acid
Diarrhea
FDR,
false
discovery
rate
GCA,
glycocholic
acid
Gastrointestinal
toxicity
IBIL,
indirect
bilirubin
IT-TOF/MS,
ion
trap/time-offlight
hybrid
mass
spectrometry
Individual
differences
Irinotecan
Lys,
lysine
MSTFA,
N-methyl-N-trifluoroacetamide
Metabolomics
NS,
non-sensitive
group
NSgt,
non-sensitive
for
gastrointestinal
toxicity
NSmt,
non-sensitive
for
myelosuppression
toxicity
OPLS-DA,
orthogonal
partial
least-squares-discriminant
analysis
PCA,
principal
component
analysis
PLS-DA,
partial
least-squares-discriminant
analysis
Phe,
phenylalanine
Prediction
QC,
quality
control
RSD,
relative
standard
deviation
S,
sensitive
group
Sgt,
sensitive
for
gastrointestinal
toxicity
Smt,
sensitive
for
myelosuppression
toxicity
T,
CPT-11
treated
group
Trp,
tryptophan
UFLC,
ultrafast
liquid
chromatography
VIP,
variable
importance
in
the
projection
pFDR,
false-discovery-rate-adjusted
P
value
assaydevelopmentfordeterminationofdz2002anewreversiblesahhinhibitoranditsacidmetabolitedzainbloodandapplicationtoratpharmacokineticstudy
期刊论文
药物分析学报英文版, 2019, 卷号: 009, 期号: 001, 页码: 25
作者:
Weiwei Jia
;
Jing Li
;
Feifei Du
;
Yan Sun
;
Fang Xu
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/07/01
S-adenosyl-L-homocysteine
hydrolase
DZ2002
Carboxylesterases
Pharmacokinetics
Chiral derivatization coupled with liquid chromatography/mass spectrometry for determining ketone metabolites of hydroxybutyrate enantiomers
期刊论文
CHINESE CHEMICAL LETTERS, 2018, 卷号: 29, 期号: 1
作者:
Cheng, Qing-Yun
;
Xiong, Jun
;
Wang, Fang
;
Yuan, Bi-Feng
;
Feng, Yu-Qi
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
2-Hydroxybutyric acid
3-Hydroxybutyric acid
Enantiomer
Chiral derivatization
Mass spectrometry
Efficient Biosynthesis of (R)- or (S)-2-Hydroxybutyrate from l-Threonine through a Synthetic Biology Approach
期刊论文
ADVANCED SYNTHESIS & CATALYSIS, 2016, 卷号: 358, 期号: 18, 页码: 2923-2928
作者:
Yao, Peiyuan
;
Cui, Yunfeng
;
Yu, Shanshan
;
Du, Yuncheng
;
Feng, Jinhui
收藏
  |  
浏览/下载:83/0
  |  
提交时间:2017/03/21
biotransformations
enzyme catalysis
(R)-2-hydroxybutyric acid
(S)-2-hydroxybutyric acid
multi-enzyme cascade reaction
Biodegradation of kraft lignin by a newly isolated anaerobic bacterial strain, Acetoanaerobium sp WJDL-Y2
期刊论文
LETTERS IN APPLIED MICROBIOLOGY, 2016, 卷号: 62, 期号: 1, 页码: 55-62
作者:
Duan, J.
;
Huo, X.
;
Du, W. J.
;
Liang, J. D.
;
Wang, D. Q.
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2019/10/09
16S rRNA gene sequencing
Acetoanaerobium sp WJDL-Y2
GC-MS
growth kinetics
kraft lignin degradation
response surface methodology
A case report of 3-hydroxybutyric aciduria with cerebellar ataxia
期刊论文
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2016, 卷号: 9, 期号: 2, 页码: 1829-1835
作者:
Chen, Xiao-Peng[1]
;
Cao, Wei[2]
;
Zhou, Xiao-Ping[3]
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/24
Ataxia
organic aciduria
3-hydroxybutyric aciduria
©版权所有 ©2017 CSpace - Powered by
CSpace