Metabolomics Characterizes the Effects and Mechanisms of Quercetin in Nonalcoholic Fatty Liver Disease Development

	Metabolomics Characterizes the Effects and Mechanisms of Quercetin in Nonalcoholic Fatty Liver Disease Development
	Xu, Yan; Han, Jichun; Dong, Jinjin; Fan, Xiangcheng; Cai, Yuanyuan; Li, Jing; Wang, Tao; Zhou, Jia; Shang, Jing
刊名	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
	2019
卷号	20 期号:5
关键词	nonalcoholic fatty liver disease high fat-sucrose diet metabolomics HPLC-QTOF-MS quercetin
英文摘要	As metabolomics is widely used in the study of disease mechanisms, an increasing number of studies have found that metabolites play an important role in the occurrence of diseases. The aim of this study is to investigate the effects and mechanisms of quercetin in high-fat-sucrose diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) development using nontargeted metabolomics. A rat model of NAFLD was established by feeding with an HFD for 30 and 50 days. The results indicated quercetin exhibited hepatoprotective activity in 30-day HFD-induced NAFLD rats by regulating fatty acid related metabolites (adrenic acid, etc.), inflammation-related metabolites (arachidonic acid, etc.), oxidative stress-related metabolites (2-hydroxybutyric acid) and other differential metabolites (citric acid, etc.). However, quercetin did not improve NAFLD in the 50-day HFD; perhaps quercetin was unable to reverse the inflammation induced by a long-term high-fat diet. These data indicate that dietary quercetin may be beneficial to NAFLD in early stages. Furthermore, combining metabolomics and experimental approaches opens avenues to study the effects and mechanisms of drugs for complex diseases.
内容类型	期刊论文
源URL	[http://210.75.249.4/handle/363003/59840]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Xu, Yan,Han, Jichun,Dong, Jinjin,et al. Metabolomics Characterizes the Effects and Mechanisms of Quercetin in Nonalcoholic Fatty Liver Disease Development[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2019,20(5).
APA	Xu, Yan.,Han, Jichun.,Dong, Jinjin.,Fan, Xiangcheng.,Cai, Yuanyuan.,...&Shang, Jing.(2019).Metabolomics Characterizes the Effects and Mechanisms of Quercetin in Nonalcoholic Fatty Liver Disease Development.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,20(5).
MLA	Xu, Yan,et al."Metabolomics Characterizes the Effects and Mechanisms of Quercetin in Nonalcoholic Fatty Liver Disease Development".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 20.5(2019).