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上海药物研究所 [7]
中国医学科学院 北京... [2]
中南大学 [1]
华南理工大学 [1]
上海大学 [1]
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期刊论文 [14]
发表日期
2016 [14]
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GPR40 agonists for the treatment of type 2 diabetes mellitus: The biological characteristics and the chemical space
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 期号: 23, 页码: 5603-5612
作者:
Chen, Cheng
;
Li, He
;
Long, Ya-Qiu
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
GPR40
Glucose-stimulated insulin secretion
Type 2 diabetes
FFA1
Biased agonism
RNA-binding protein CUGBP1 regulates insulin secretion via activation of phosphodiesterase 3B in mice
期刊论文
DIABETOLOGIA, 2016, 卷号: 59, 期号: 9, 页码: 1959-1967
作者:
Zhai, Kui
;
Gu, Lei
;
Yang, Zhiguang
;
Mao, Yang
;
Jin, Meng
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
cAMP
CUGBP1
Insulin secretion
PDE3B
RNA-binding protein
Type 2 diabetes
Trimer procyanidin oligomers contribute to the protective effects of cinnamon extracts on pancreatic beta-cells in vitro
期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 8, 页码: 1083-1090
作者:
Sun, Peng
;
Wang, Ting
;
Chen, Lu
;
Yu, Bang-wei
;
Jia, Qi
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/01/08
cinnamon
procyanidin oligomers
cinnamtannin B1
procyanidin C1
cinnamtannin D1
diabetes
pancreatic beta-cells
cultured murine islets
lipotoxicity
ROS
insulin secretion
Advances in Small-Molecule GPR40 Agonists for Treatment of Type 2 Diabetes Mellitus
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2016, 卷号: 36, 期号: 4, 页码: 736-743
作者:
Li He
;
Long Yaqiu
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
type II diabetes mellitus
GPR40
agonists
glucose-stimulated insulin secretion
phenylpropanoic acid
Trimer procyanidin oligomers contribute to the protective effects of cinnamon extracts on pancreatic beta-cells in vitro
期刊论文
中国药理学报, 2016, 卷号: 37, 期号: 8
作者:
Sun Peng
;
Wang Ting
;
Chen Lu
;
Yu Bangwei
;
Jia Qi
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/05
cinnamon
procyanidin oligomers
cinnamtannin B1
procyanidin C1
cinnamtannin D1
diabetes
pancreatic beta-cells
cultured murine islets
lipotoxicity
ROS
insulin secretion
Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells
期刊论文
Cellular Signalling, 2016, 卷号: 28, 期号: 8, 页码: 1099-1104
作者:
Wang, Jing
;
Yang, Xin
;
Zhang, Jingjing*
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/12/03
4E-BP1
4E binding protein
AMPK
AMP-activated protein kinase
ATF6
activating transcription factor 6
ATP
adenosine triphosphate
DEPTOR
DEP domain containing mTOR-interacting protein
CI
complexes I
CII
complex II
CIII
complex III
CIV
complex IV
CV
complex V
eIF2α
Eukaryotic Initiation Factor 2α
ER
Endoplasmic Reticulum
ERAD
ER-associated degradation
ERO1α
ER oxidoreductase 1 α
FoxO1
Forkhead box O1
GβL
G Protein β Subunit Like Protein
GRP78
78 kDa glucose-regulated protein precursor
GSIS
glucose-stimulated insulin secretion
IRE1
Inositol-requiring enzyme 1
IRS1
Insulin receptor substrate 1
IRS2
Insulin receptor substrate 2
mLST8
mammalian lethal with sec-13 protein 8
mSin1
the mammalian stress-activated MAP kinase-interaction protein 1
mtDNA
mitochondrial deoxyribonucleic acid
mTOR
mammalian TOR
mTORC1
mTOR complex 1
mTORC2
mTOR complex 2
NADPH oxidase
Nicotinamide adenine dinucleotide phosphate-oxidase
NOS
nitric oxide synthase
O2–·
superoxide anion
H2O2
hydrogen peroxide
OH·
hydroxyl radical
3O2
triplet-state molecular oxygen
OXPHOS
oxidative phosphorylation
CAT
catalase
GPx
glutathioneperoxidase
PERK
Protein kinase R-like endoplasmic reticulum kinase
PDI
ER protein disulfide isomerases
PI3K
the phosphoinositide3-kinase
PRAS40
40-kDa proline-rich Akt substrate
PRAS40
the 40-kDa proline-rich Akt substrate
PROTOR
the protein observed with RICTOR
RAPTOR
regulatory-associated protein of mTOR
RICTOR
The rapamycin-insensitive companion of mTOR
REDD1
DNA damage response 1
RNS
reactive nitrogen species
ROS
reactive oxygen species
RNS
reactive nitrogen species
S6K
S6 kinase
SOD
superoxidedismutase
T1DM
Type 1 diabetes mellitus
T2DM
Type 2 diabetes mellitus
TOR
the target of rapamycin
TSC2
Tuberous sclerosis 2
UPR
unfolded protein response
Mitochondrial oxidative stress
ER stress
mTOR
Pancreatic β cells
Niacin receptor GPR109A inhibits insulin secretion and is down-regulated in type 2 diabetic islet beta-cells
期刊论文
GENERAL AND COMPARATIVE ENDOCRINOLOGY, 2016, 卷号: 237, 页码: 98-108
作者:
Wang, Na[1]
;
Guo, De-yu[4]
;
Tian, Xiong[1]
;
Lin, Hao-peng[1]
;
Li, Yun-pan[1]
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/04/24
GPR109A
Insulin secretion
Niacin
Diabetes
Insulinoma
GPR40 agonists for the treatment of type 2 diabetes mellitus: The biological characteristics and the chemical space
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 页码: 5603-5612
作者:
Chen, Cheng[1]
;
Li, He[2]
;
Long, Ya-Qiu[3]
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/04/26
GPR40
Glucose-stimulated insulin secretion
Type 2 diabetes
FFA1
Biased agonism
Antidiabetic and antihyperlipidemic activities of Forsythia suspensa (Thunb.) Vahl (fruit) in streptozotocin-induced diabetes mice
期刊论文
Journal of Ethnopharmacology, 2016, 卷号: 192, 页码: 256-263
作者:
Zhang, Yanyan
;
Feng, Fu
;
Chen, Ting
;
Li, Zhongwen
;
Shen, Qingwu W
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/23
Antidiabetic
Antihyperlipidemic
Diabetes mellitus
Forsythia suspensa (Thunb.) Vahl
Insulin secretion
Cannabinoid 2 Receptor Agonist Improves Systemic Sensitivity to Insulin in High-Fat Diet/Streptozotocin-Induced Diabetic Mice
期刊论文
2016, 卷号: 40, 期号: 5, 页码: 1175-1185
作者:
Zhang, Xiuyuan
;
Gao, Shan
;
Niu, Jinfeng
;
Li, Pan
;
Deng, Juan
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/01/04
Cannabinoid 2 receptor
Diabetes
Insulin secretion
Inflammation
Lipolytic
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