CORC

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CORC

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Discovery of an M-Substituted N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active kappa-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12414-12433
作者:  He, Qian;  Wei, Yuanyuan;  Liu, Xiao;  Ye, Rongrong;  Kong, Linghui
收藏  |  浏览/下载：88/0  |  提交时间：2021/11/04
Exploration of the SAR Connection between Morphinan- and Arylacetamide-Based kappa Opioid Receptor (kappa OR) Agonists Using the Strategy of Bridging 期刊论文
ACS CHEMICAL NEUROSCIENCE, 2021, 卷号: 12, 期号: 6, 页码: 1018-1030
作者:  Liu, Xiao;  Jiang, Shuang;  Kong, Linghui;  Ye, Rongrong;  Xiao, Li
收藏  |  浏览/下载：114/0  |  提交时间：2021/05/24
Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 31, 页码: 10842-10856
作者:  Liu, Wen;  Yin, Ye;  Wang, Meijing;  Fan, Ting;  Zhu, Yuyu
收藏  |  浏览/下载：237/0  |  提交时间：2020/12/24
Novel cyclophosphamide of natural products osalmide and pterostilbene induces cytotoxicity and cell cycle arrest in diffuse large B-cell lymphoma cells 期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2020, 卷号: 52, 期号: 4, 页码: 401-410
作者:  Xi, Mengyu;  He, Wan;  Li, Bo;  Zhou, Jinfeng;  Xu, Zhijian
收藏  |  浏览/下载：44/0  |  提交时间：2020/12/24
Novel cyclophosphamide of natural products osalmide and pterostilbene induces cytotoxicity and cell cycle arrest in diffuse large B-cell lymphoma cells 期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2020, 卷号: 52, 期号: 4, 页码: 401-410
作者:  Xi, Mengyu;  He, Wan;  Li, Bo;  Zhou, Jinfeng;  Xu, Zhijian
收藏  |  浏览/下载：23/0  |  提交时间：2020/12/24
Loss of hnRNP A1 in murine skeletal muscle exacerbates high-fat diet-induced onset of insulin resistance and hepatic steatosis 期刊论文
JOURNAL OF MOLECULAR CELL BIOLOGY, 2020, 卷号: 12, 期号: 4, 页码: 277-290
作者:  Zhao, Mingxia;  Shen, Lihong;  Ouyang, Zijun;  Li, Manru;  Deng, Guoliang
收藏  |  浏览/下载：23/0  |  提交时间：2020/12/24
Discovery of a Highly Selective and Potent kappa Opioid Receptor Agonist from N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 24, 页码: 11054-11070
作者:  Xiao, Li;  Wang, Yujun;  Zhang, Mumei;  Wu, Weiwei;  Kong, Linghui
收藏  |  浏览/下载：93/0  |  提交时间：2020/07/01
Coxsackievirus A10 atomic structure facilitating the discovery of a broad-spectrum inhibitor against human enteroviruses 期刊论文
CELL DISCOVERY, 2019, 卷号: 5, 页码: 15
作者:  Chen, Jinhuan;  Ye, Xiaohua;  Zhang, Xue-Yang;  Zhu, Zhengdan;  Zhang, Xiang
收藏  |  浏览/下载：31/0  |  提交时间：2020/07/01
Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1 期刊论文
ACS CHEMICAL BIOLOGY, 2018, 卷号: 13, 期号: 3, 页码: 772-781
作者:  Ye, Fei;  Kong, Xiangqian;  Zhang, Hao;  Liu, Yan;  Shao, Zhiyuan
收藏  |  浏览/下载：36/0  |  提交时间：2019/01/08
Discovery of two aminoglycoside antibiotics as inhibitors targeting the menin-mixed lineage leukaemia interface 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 卷号: 24, 期号: 9, 页码: 2090-2093
作者:  Li, Lianchun;  Zhou, Ran;  Geng, Heji;  Yue, Liyan;  Ye, Fei
收藏  |  浏览/下载：24/0  |  提交时间：2019/01/08

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