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科研机构
上海药物研究所 [25]
内容类型
期刊论文 [25]
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2021 [3]
2020 [1]
2019 [4]
2018 [4]
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Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 11
作者:
Fan, Shijie
;
Yue, Liyan
;
Wan, Wei
;
Zhang, Yuanyuan
;
Zhang, Bidong
收藏
  |  
浏览/下载:80/0
  |  
提交时间:2021/12/16
covalent modification
probes
proteome
LC3
post-translational modification
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 12, 页码: 8194-8207
作者:
Du, Daohai
;
Xu, Dandan
;
Zhu, Licheng
;
Stazi, Giulia
;
Zwergel, Clemens
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  |  
浏览/下载:74/0
  |  
提交时间:2021/08/17
PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma
期刊论文
THERANOSTICS, 2021, 卷号: 11, 期号: 11, 页码: 5387-5403
作者:
Wang, Jianfeng
;
Wang, Chen
;
Xu, Pan
;
Li, Xiao
;
Lu, Yongning
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  |  
浏览/下载:130/0
  |  
提交时间:2021/05/24
clear cell renal cell carcinoma
protein arginine methyltransferase 1
therapeutic
lipocalin2 (LCN2)
sunitinib
Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion
期刊论文
ADVANCED SCIENCE, 2020, 页码: 13
作者:
Sun, Zhongya
;
Zhang, Hao
;
Zhang, Yuanyuan
;
Liao, Liping
;
Zhou, Wen
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  |  
浏览/下载:107/0
  |  
提交时间:2020/07/01
anti-metastasis activities
crystal structures
inhibitors
novel pockets
rho family proteins
Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 184, 页码: 15
作者:
Lu, Wenchao
;
Wang, Jun
;
Li, Yong
;
Tao, Hongru
;
Xiong, Huan
收藏
  |  
浏览/下载:94/0
  |  
提交时间:2020/07/01
Hippo pathway
TEAD transcription factor
Covalent inhibitor
Palmitoylation inhibitor
Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 164, 页码: 317-333
作者:
Shao, Jingwei
;
Zhu, Kongkai
;
Du, Daohai
;
Zhang, Yuanyuan
;
Tao, Hongrui
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  |  
浏览/下载:35/0
  |  
提交时间:2020/07/01
PRMT5 inhibitors
N-Substituted 1,2,3,4-tetrahydroisoquinoline derivatives
Anti-tumor
Discovery of trisubstituted nicotinonitrile derivatives as novel human GCN5 inhibitors through AlphaScreen-based high throughput screening
期刊论文
RSC ADVANCES, 2019, 卷号: 9, 期号: 9, 页码: 4917-4924
作者:
Tao, Hongru
;
Wang, Jun
;
Lu, Wenchao
;
Zhang, Rukang
;
Xie, Yiqian
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  |  
浏览/下载:41/0
  |  
提交时间:2020/07/01
p300/CBP inhibitor A-485 alleviates acute liver injury by regulating macrophage activation and polarization
期刊论文
THERANOSTICS, 2019, 卷号: 9, 期号: 26, 页码: 8344-8361
作者:
Peng, Jinjin
;
Li, Jiacheng
;
Huang, Jing
;
Xu, Pan
;
Huang, Heming
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
liver injury
inflammation
macrophages
epigenetics
acetyltransferase inhibitor
Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations
期刊论文
BIOORGANIC CHEMISTRY, 2018, 卷号: 81, 页码: 289-298
作者:
Zhu, Kongkai
;
Tao, Hongrui
;
Song, Jia-Li
;
Jin, Lu
;
Zhang, Yuanyuan
收藏
  |  
浏览/下载:130/0
  |  
提交时间:2019/01/08
PRMT5 inhibitor
Arginine methylation
Virtual screening
Molecular docking
Molecular dynamics simulation
Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma
期刊论文
ONCOGENESIS, 2018, 卷号: 7
作者:
Chen, Wei
;
Zhang, Hao
;
Chen, Zhifeng
;
Jiang, Hao
;
Liao, Liping
收藏
  |  
浏览/下载:108/0
  |  
提交时间:2019/01/08
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