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浏览/检索结果: 共45条，第1-10条 帮助 限定条件 发表日期：2021    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo 期刊论文 CANCER SCIENCE, 2021, 页码: 12 作者:  Liu, Yingqiang;  Lai, Mengzhen;  Li, Shan;  Wang, Yanan;  Feng, Fang 收藏  |  浏览/下载：62/0  |  提交时间：2022/01/18 C797S  epidermal growth factor receptor  fourth-generation EGFR TKI  non-small cell lung cancer  osimertinib resistance   STING inhibitor ameliorates LPS-induced ALI by preventing vascular endothelial cells-mediated immune cells chemotaxis and adhesion 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12 作者:  Wu, Bing;  Xu, Meng-meng;  Fan, Chen;  Feng, Chun-lan;  Lu, Qiu-kai 收藏  |  浏览/下载：59/0  |  提交时间：2022/01/18 acute lung injury  STING  vascular endothelial cells  inflammatory cytokines  chemokines  chemotaxis   Discovery and structure - activity relationship exploration of pyrazolo [1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 48, 页码: 13 作者:  Chen, Yun;  Bai, Gang;  Li, Yan;  Ning, Yi;  Cao, Sufen 收藏  |  浏览/下载：32/0  |  提交时间：2021/12/01 FLT3  FLT3-ITD  Acute myeloid leukemia  Structure-activity relationships  Pyrazolo[1, 5-a]pyrimidine   Synthesis and bioactivity studies of covalent inhibitors derived from (-)-Chaetominine 期刊论文 JOURNAL OF MOLECULAR STRUCTURE, 2021, 卷号: 1241, 页码: 14 作者:  Zhou, Xian;  Feng, Xuexin;  Wang, Dachi;  Chen, Deheng;  Wu, Gaoxing 收藏  |  浏览/下载：85/0  |  提交时间：2021/08/17 Chaetominine  Cellular growth inhibition  Cancer cell line  Covalent warhead   Enhancing the Potential of Miniature-Scale DNA-Compatible Radical Reactions via an Electron Donor-Acceptor Complex and a Reversible Adsorption to Solid Support Strategy 期刊论文 ORGANIC LETTERS, 2021, 卷号: 23, 期号: 19, 页码: 7381-7385 作者:  Lin, Bizhen;  Lu, Weiwei;  Chen, Zhen-yu;  Zhang, Yue;  Duan, Yin-zhe 收藏  |  浏览/下载：13/0  |  提交时间：2021/12/01 Strategy of De Novo Design toward First-In-Class Imaging Agents for Simultaneously Differentiating Glioma Boundary and Grades 期刊论文 ACS SENSORS, 2021, 卷号: 6, 期号: 9, 页码: 3330-3339 作者:  Yan, Feng;  Zhuang, Jianfeng;  Yu, Qian;  Dou, Zhangqi;  Jiang, Xuefeng 收藏  |  浏览/下载：58/0  |  提交时间：2021/11/04 fluorescent probe  bioinformatics analysis  PDGFR beta  glioma imaging  glioma grading   New formamidobisabolene-type sesquiterpenoids from a Hainan Sponge Halichondria sp. 期刊论文 TETRAHEDRON, 2021, 卷号: 96, 页码: 7 作者:  Chen, Bao;  Li, Wang-Sheng;  Gu, Yu-Cheng;  Zhang, Hai-Yan;  Luo, Hui 收藏  |  浏览/下载：17/0  |  提交时间：2021/11/04 Sponge  Halichondria sp  Anti-inflammatory activity  Sesquiterpenes   A validated HPLC-MS/MS method for determination of simmitecan and its metabolite chimmitecan in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor 期刊论文 JOURNAL OF SEPARATION SCIENCE, 2021, 页码: 8 作者:  Zhou, Jun;  Zhan, Yan;  Zhong, Dafang;  Chen, Xiaoyan;  Zhang, Yifan 收藏  |  浏览/下载：72/0  |  提交时间：2021/11/04 chimmitecan  mass spectrometry  pharmacokinetics  simmitecan  solid tumors   Novel selective kappa agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11 作者:  Wei, Yuan-yuan;  Ma, Yan;  Yao, Song-yu;  Kong, Ling-hui;  Liu, Xiao 收藏  |  浏览/下载：40/0  |  提交时间：2021/11/04 kappa-opioid receptor agonist  4,5-expoxymorphinan  antinociception  conditioned place aversion  sedation  U50,488H  morphine  Nor-BNI  beta-FNA   Imatinib inhibits the malignancy of hepatocellular carcinoma by suppressing autophagy 期刊论文 EUROPEAN JOURNAL OF PHARMACOLOGY, 2021, 卷号: 906, 页码: 8 作者:  Xiao, Meng-Chao;  Qian, Hui;  Huang, Chen-Kai;  Zheng, Bai-Nan;  Yan, Fang-Zhi 收藏  |  浏览/下载：50/0  |  提交时间：2021/11/04 Imatinib  Autophagy  Hepatocarcinoma  Sorafenib  Synergetic effect