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科研机构
中国医学科学院 北京... [3]
湖南中医药大学 [1]
内容类型
期刊论文 [4]
发表日期
2016 [4]
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The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect
期刊论文
2016, 卷号: 162, 页码: 179-187
作者:
Chu, Shifeng
;
Liu, Shaolin
;
Duan, Wenzhen
;
Cheng, Yong
;
Jiang, Xueying
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  |  
浏览/下载:2/0
  |  
提交时间:2020/01/04
Chirality
Clausenamide
Dementia
Long-term potentiation
Signaling pathway
Calcium
20C, a bibenzyl compound isolated from Gastrodia elata, protects PC12 cells against rotenone-induced apoptosis via activation of the Nrf2/ARE/HO-1 signaling pathway
期刊论文
2016, 卷号: 37, 期号: 6, 页码: 731-740
作者:
Huang Juyang
;
Yuan Yuhe
;
Yan Jiaqing
;
Wang Yanan
;
Chu Shifeng
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  |  
浏览/下载:10/0
  |  
提交时间:2020/01/04
bibenzyl compound
Gastrodia elata
rotenone
apoptosis
oxidative stress
Nrf2
neuroprotection
Parkinson's disease
PC12 cells
Simultaneous quantification of ginsenoside Rg1 and its metabolites by HPLC-MS/MS: Rg1 excretion in rat bile, urine and feces
期刊论文
2016, 卷号: 6, 期号: 6, 页码: 593-599
作者:
He, Chiyu
;
Feng, Ru
;
Sun, Yupeng
;
Chu, Shifeng
;
Chen, Ji
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  |  
浏览/下载:4/0
  |  
提交时间:2020/01/04
Ginsenoside Rg1
Ginsenoside Rh1
Protopanaxatriol
Excretion
LC-MS/MS
The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect
期刊论文
Pharmacology and Therapeutics, 2016, 卷号: 162, 页码: 179-187
作者:
Chu, Shifeng
;
Liu, Shaolin
;
Duan, Wenzhen
;
Cheng, Yong
;
Jiang, Xueying
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/27
Chirality
Clausenamide
Dementia
Long-term potentiation
Signaling pathway
Calcium
6-OHDA
6-hydroxyldopamine
ACE
acetylcholinesterase
ACh
acetylcholine
AD
Alzheimer's disease
AUC0–12 h
0–12 h area under curve
APP
amyloid precursor protein
APV
R-2-amino-5-phosphonopentanoate
AUC0−∝
whole area under curve
BBB
blood–brain barrier
BDNF
brain-derived neurotrophic factor
CaM
calmodulin
CaMKII
calmodulin kinase II
ChAT
choline acetyltransferase
CREB
cAMP responding element binding
CHM
Chinese herbal medicine
clau
clausenamide
CL
clearance
Cmax
maximum concentration
CDK-5
cyclin-dependent kinase-5
DM
diabetes mellitus
DAG
diacylglycerol
ER
endoplasmic reticulum
ERK
extracellular signal-regulated kinases
GSK-3
glycogen synthase kinase-3
IP3
inositol triphosphate
LTP
long term potentiation
MWM
Morris water maze
NGF
nerve growth factor
NMDA
N-Methyl-D-aspartate
D
nNOS
neural nitric oxide synthase
PAT
passive avoidance tasks
Pir
piracetam
PLC
phospholipase C
PP1
phosphate 1
PKC
protein kinase C
tmax
time of peak concentration
t1/2α
absorption half-life
t1/2β
elimination half-life
Tau
microtubule-associated proteins
TCM
traditional Chinese medicine
Vd
apparent volume of distribution
VDCC
voltage-dependent calcium channel
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