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	The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect
	Chu, Shifeng; Liu, Shaolin; Duan, Wenzhen; Cheng, Yong; Jiang, Xueying; Zhu, Chuanjiang; Tang, Kang; Wang, Runsheng; Xu, Lin; Wang, Xiaoying
刊名	Pharmacology and Therapeutics
	2016
卷号	162页码:179-187
关键词	Chirality Clausenamide Dementia Long-term potentiation Signaling pathway Calcium 6-OHDA 6-hydroxyldopamine ACE acetylcholinesterase ACh acetylcholine AD Alzheimer's disease AUC0–12 h 0–12 h area under curve APP amyloid precursor protein APV R-2-amino-5-phosphonopentanoate AUC0−∝ whole area under curve BBB blood–brain barrier BDNF brain-derived neurotrophic factor CaM calmodulin CaMKII calmodulin kinase II ChAT choline acetyltransferase CREB cAMP responding element binding CHM Chinese herbal medicine clau clausenamide CL clearance Cmax maximum concentration CDK-5 cyclin-dependent kinase-5 DM diabetes mellitus DAG diacylglycerol ER endoplasmic reticulum ERK extracellular signal-regulated kinases GSK-3 glycogen synthase kinase-3 IP3 inositol triphosphate LTP long term potentiation MWM Morris water maze NGF nerve growth factor NMDA N-Methyl-D-aspartate D nNOS neural nitric oxide synthase PAT passive avoidance tasks Pir piracetam PLC phospholipase C PP1 phosphate 1 PKC protein kinase C tmax time of peak concentration t1/2α absorption half-life t1/2β elimination half-life Tau microtubule-associated proteins TCM traditional Chinese medicine Vd apparent volume of distribution VDCC voltage-dependent calcium channel
ISSN号	0163-7258
DOI	10.1016/j.pharmthera.2016.01.002
URL标识	查看原文
WOS记录号	WOS:000378361300014
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/5706375
专题	湖南中医药大学
作者单位	1.[Yu, Xiaoming 2.Cheng, Yong 3.Wu, Kemei 4.Wang, Yan 5.Wang, Muzou 6.Zhang, Juntian 7.Zhu, Chuanjiang 8.Chu, Shifeng] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China.
推荐引用方式 GB/T 7714	Chu, Shifeng,Liu, Shaolin,Duan, Wenzhen,et al. The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect[J]. Pharmacology and Therapeutics,2016,162:179-187.
APA	Chu, Shifeng.,Liu, Shaolin.,Duan, Wenzhen.,Cheng, Yong.,Jiang, Xueying.,...&Zhang, Juntian*.(2016).The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect.Pharmacology and Therapeutics,162,179-187.
MLA	Chu, Shifeng,et al."The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect".Pharmacology and Therapeutics 162(2016):179-187.

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