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浏览/检索结果: 共10条，第1-10条 帮助 限定条件 发表日期：2015     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 3: Optimization of [1,2,4]triazolo[1,5-a]pyrimidine core via structure-based and physicochemical property-driven approaches 期刊论文 European Journal of Medicinal Chemistry: Chimie Therapeutique, 2015, 页码: 754-765 作者:  Huang, Boshi;  Li, Cuicui;  Chen, Wenmin;  Liu, Tao;  Yu, Mingyan 收藏  |  浏览/下载：6/0  |  提交时间：2019/12/17 Triazolopyrimidines  Structure-based drug design  Biological activity  HIV-1 RT  Physicochemical properties  Molecular simulations   Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 3: Optimization of [1,2,4]triazolo[1,5-a]pyrimidine core via structure-based and physicochemical property-driven approaches 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 卷号: 92, 页码: 754-765 作者:  Huang, Boshi;  Li, Cuicui;  Chen, Wenmin;  Liu, Tao;  Yu, Mingyan 收藏  |  浏览/下载：3/0  |  提交时间：2019/12/17 Triazolopyrimidines  Structure-based drug design  Biological activity  HIV-1 RT  Physicochemical properties  Molecular simulations   Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 4: Design, synthesis and biological evaluation of novel imidazo[1,2-a]pyrazines 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 卷号: 93, 页码: 330-337 作者:  Huang, Boshi;  Liang, Xin;  Li, Cuicui;  Chen, Wenmin;  Liu, Tao 收藏  |  浏览/下载：5/0  |  提交时间：2019/12/17 HIV-1 RT  Imidazo[1,2-a]pyrazines  Core-refining  NNRTIs  Biological  activity  Molecular simulation   Design, Synthesis, and Biological Evaluation of Novel 4-Aminopiperidinyl-linked 3,5-Disubstituted-1,2,6-thiadiazine-1,1-dione Derivatives as HIV-1 NNRTIs 期刊论文 Chemical biology and drug design, 2015, 卷号: 86, 期号: 1, 页码: 887-893 作者:  Liu, Tao;  Huang, Boshi;  Tian, Ye;  Liang, Xin;  Liu, Hong 收藏  |  浏览/下载：9/0  |  提交时间：2019/12/17 1  2  6-thiadiazine-1  1-dione  bioactivity  drug design  HIV-1  NNRTIs  RT  synthesis   Synthesis and Preliminary Antiviral Activities of Piperidine-substituted Purines against HIV and Influenza A/H1N1 Infections 期刊论文 CHEMICAL BIOLOGY & DRUG DESIGN, 2015, 卷号: 86, 期号: 4, 页码: 568-577 作者:  Kang, Dongwei;  Fang, Zengjun;  Huang, Boshi;  Zhang, Lingzi;  Liu, Huiqing 收藏  |  浏览/下载：2/0  |  提交时间：2019/12/17 bioactivity  heterocycle  HIV  influenza virus  NNRTIs  structure-activity relationship  synthesis   Medicinal chemistry insights in the discovery of novel LSD1 inhibitors 期刊论文 EPIGENOMICS, 2015, 卷号: 7, 期号: 8, 页码: 1379-1396 作者:  Wang, Xueshun;  Huang, Boshi;  Suzuki, Takayoshi;  Liu, Xinyong;  Zhan, Peng 收藏  |  浏览/下载：4/0  |  提交时间：2019/12/17 drug design  epigenomics  histone modification  LSD1  medicinal  chemistry   Synthesis and Biological Evaluation of a Series of 2-((1-substituted-1H-1,2,3-triazol-4-yl)methylthio)-6-(naphthalen-1-ylme thyl)pyrimidin-4(3H)-one As Potential HIV-1 Inhibitors 期刊论文 CHEMICAL BIOLOGY & DRUG DESIGN, 2015, 卷号: 86, 期号: 4, 页码: 614-618 作者:  Fang, Zengjun;  Kang, Dongwei;  Zhang, Lingzi;  Huang, Boshi;  Liu, Huiqing 收藏  |  浏览/下载：5/0  |  提交时间：2019/12/17 antiviral activity  click chemistry  drug design  HIV  NNRTIs  pyrimidine  SAR   Fragment-based approaches to anti-HIV drug discovery: state of the art and future opportunities 期刊论文 EXPERT OPINION ON DRUG DISCOVERY, 2015, 卷号: 10, 期号: 12, 页码: 1271-1281 作者:  Huang, Boshi;  Kang, Dongwei;  Zhan, Peng;  Liu, Xinyong 收藏  |  浏览/下载：8/0  |  提交时间：2019/12/17 AIDS  drug design  fragment-based drug design  HIV  medicinal chemistry  protease  reverse transcriptase   Novel fluorine-containing DAPY derivatives as potent HIV-1 NNRTIs: a patent evaluation of WO2014072419 期刊论文 EXPERT OPINION ON THERAPEUTIC PATENTS, 2015, 卷号: 25, 期号: 12, 页码: 1477-1486 作者:  Meng, Qing;  Liu, Na;  Huang, Boshi;  Zhan, Peng;  Liu, Xinyong 收藏  |  浏览/下载：5/0  |  提交时间：2019/12/17 diarylpyrimidines  drug design  fluorine atom  HIV inhibitors  non-nucleoside reverse transcriptase inhibitors   Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 4: Design, synthesis and biological evaluation of novel imidazo[1,2-a]pyrazines 期刊论文 European Journal of Medicinal Chemistry: Chimie Therapeutique, 2015, 页码: 330-337 作者:  Huang, Boshi;  Liang, Xin;  Li, Cuicui;  Chen, Wenmin;  Liu, Tao 收藏  |  浏览/下载：3/0  |  提交时间：2019/12/17 HIV-1 RT  Imidazo[1  2-a]pyrazines  Core-refining  NNRTIs  Biological activity  Molecular simulation