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科研机构
上海药物研究所 [48]
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期刊论文 [47]
会议论文 [1]
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2021 [1]
2020 [4]
2019 [4]
2018 [1]
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Inhibition of PDE4 by apremilast attenuates skin fibrosis through directly suppressing activation of M1 and T cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Lu, Qiu-kai
;
Fan, Chen
;
Xiang, Cai-gui
;
Wu, Bing
;
Lu, Hui-min
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2021/06/11
PDE4
apremilast
skin fibrosis
macrophages
Targeted Drugs for Treatment of Pulmonary Arterial Hypertension: Past, Present, and Future Perspectives
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 24, 页码: 15153-15186
作者:
Zheng, Wei
;
Wang, Zhen
;
Jiang, Xiangrui
;
Zhao, Qingjie
;
Shen, Jingshan
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/05/24
SR mu CT Reveals 3D Microstructural Alterations of the Vascular and Neuronal Network in a Rat Model of Chronic Compressive Thoracic Spinal Cord Injury
期刊论文
AGING AND DISEASE, 2020, 卷号: 11, 期号: 3, 页码: 603-617
作者:
Jiang, Liyuan
;
Cao, Yong
;
Liu, Zhen
;
Ni, Shuangfei
;
Liu, Jun
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2020/07/01
chronic spinal cord injury
neurovascular unit
spinal cord microvasculature
SR mu CT
3D
Lead discovery, chemical optimization, and biological evaluation studies of novel histone methyltransferase SET7 small-molecule inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 9, 页码: 10
作者:
Hou, Zeng
;
Min, Wenjian
;
Zhang, Rukang
;
Niu, Ao
;
Li, Yuanqing
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  |  
浏览/下载:44/0
  |  
提交时间:2020/07/01
Histone methylation
SET7
Small-molecule inhibitor
Virtual screening
Molecular probe
Lipoprotein-associated phospholipase A2: The story continues
期刊论文
MEDICINAL RESEARCH REVIEWS, 2020, 卷号: 40, 期号: 1, 页码: 79-134
作者:
Huang, Fubao
;
Wang, Kai
;
Shen, Jianhua
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  |  
浏览/下载:44/0
  |  
提交时间:2020/07/01
fragment-based lead discovery
inflammation
inhibitors
lipoprotein-associated phospholipase A2
vascular diseases
Comparison of high-resolution synchrotron-radiation-based phase-contrast imaging and absorption-contrast imaging for evaluating microstructure of vascular networks in rat brain: from 2D to 3D views
期刊论文
JOURNAL OF SYNCHROTRON RADIATION, 2019, 卷号: 26, 页码: 2024-2032
作者:
Li, Hong-Lei
;
Ding, Hui
;
Yin, Xian-Zhen
;
Chen, Zhuo-Hui
;
Tang, Bin
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
2D
3D
brain
microtomography
synchrotron radiation
vascular network
High-resolution mapping of brain vasculature and its impairment in the hippocampus of Alzheimer's disease mice
期刊论文
NATIONAL SCIENCE REVIEW, 2019, 卷号: 6, 期号: 6, 页码: 1223-1238
作者:
Zhang, Xiaochuan
;
Yin, Xianzhen
;
Zhang, Jingjing
;
Li, Anan
;
Gong, Hui
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/01
Micro-Optical Sectioning Tomography
image optimization
Alzheimer's disease
impaired hippocampal vasculature
virtual vascular endoscopy
Danhong injection mobilizes endothelial progenitor cells to repair vascular endothelium injury via upregulating the expression of Akt, eNOS and MMP-9
期刊论文
PHYTOMEDICINE, 2019, 卷号: 61, 页码: 10
作者:
Hu, Zhen
;
Wang, Hong
;
Fan, Guanwei
;
Zhang, Han
;
Wang, Xiaoying
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/07/01
Danhong injection
Endothelial progenitor cells
Mobilization
Vascular repair
Expression of Akt, eNOS, and MMP-9
Sulfated polysaccharide JCS1S2 inhibits angiogenesis via targeting VEGFR2/VEGF and blocking VEGFR2/Erk/VEGF signaling
期刊论文
Carbohydrate Polymers, 2019, 卷号: 207, 页码: 502-509
作者:
Wang, Zheng
;
Jin, Can
;
Li, Xueying
;
Ding, Kan
收藏
  |  
浏览/下载:72/0
  |  
提交时间:2019/01/08
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 12, 页码: 3117-3125
作者:
Liu, Wenwen
;
Wang, Huan
;
Li, Xiaokang
;
Xu, Yixiang
;
Zhang, Jian
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2019/01/08
Depression
Cognitive impairment
Multitarget-directed ligand
5-HT1A agonist
5-HT reuptake inhibition
ChE inhibition
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