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科研机构
上海药物研究所 [25]
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期刊论文 [25]
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2021 [2]
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New monoamine antidepressant, hypidone hydrochloride (YL-0919), enhances the excitability of medial prefrontal cortex in mice via a neural disinhibition mechanism
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Zhang, Yong-Mei
;
Ye, Lu-Yu
;
Li, Tian-Yu
;
Guo, Fan
;
Guo, Fei
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/01/04
YL-0919
medial prefrontal cortex
GABAergic neurons
5-HT1A receptor
GAD67-GFP transgenic mice
disinhibition
fluoxetine
electrophysiological recording
Dezocine as a potent analgesic: overview of its pharmacological characterization
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Ye, Rong-Rong
;
Jiang, Shuang
;
Xu, Xu
;
Lu, Yan
;
Wang, Yu-Jun
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/12/16
dezocine
opioid receptors
norepinephrine
serotonin transporter
postoperative pain
anesthesia
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 12, 页码: 3117-3125
作者:
Liu, Wenwen
;
Wang, Huan
;
Li, Xiaokang
;
Xu, Yixiang
;
Zhang, Jian
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2019/01/08
Depression
Cognitive impairment
Multitarget-directed ligand
5-HT1A agonist
5-HT reuptake inhibition
ChE inhibition
Novel Vilazodone Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2017, 卷号: 8, 期号: 12, 页码: 2708-2721
作者:
Li, Xiaokang
;
Wang, Huan
;
Xu, Yixiang
;
Liu, Wenwen
;
Gong, Qi
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/01/08
Alzheimer's disease
depression
multitarget-directed ligand
ChE inhibition
5-HT1A agonist
5-HT reuptake inhibition
Reducing central serotonin in adulthood promotes hippocampal neurogenesis
期刊论文
SCIENTIFIC REPORTS, 2016, 卷号: 6
作者:
Song, Ning-Ning
;
Jia, Yun-Fang
;
Zhang, Lei
;
Zhang, Qiong
;
Huang, Ying
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/01/08
SKF83959 is a novel triple reuptake inhibitor that elicits anti-depressant activity
期刊论文
ACTA PHARMACOLOGICA SINICA, 2013, 卷号: 34, 期号: 9, 页码: 1149-1155
作者:
Fang, Xing
;
Guo, Lin
;
Jia, Jia
;
Jin, Guo-zhang
;
Zhao, Bin
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
SKF83959
monoamine transporter
serotonin
norepinephrine
dopamine
depression
DOV21947
Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 卷号: 54, 页码: 123-136
作者:
Zheng, Yong-Yong
;
Guo, Lin
;
Zhen, Xue-Chu
;
Li, Jian-Qi
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/01/08
Arylalkanol-piperidine derivatives
Triple reuptake inhibitor
Antidepressant
Design,synthesis and bioactivity of aryl piperazine benzo[b]oxazine derivatives
期刊论文
Acta Pharmaceutica Sinica, 2012, 卷号: 47, 期号: 6, 页码: 755-763
作者:
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
5-HT_(1A)
aryl piperazine benzo [b] oxazine derivatives
pharmacophore model
5-HT reuptake
5-HT_(1A)
Classification of 5-HT1A receptor agonists and antagonists using GA-SVM method
期刊论文
ACTA PHARMACOLOGICA SINICA, 2011, 卷号: 32, 期号: 11, 页码: 1424-1430
作者:
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
5-HT1A receptor
support vector machine
genetic algorithm
agonist
antagonists
(2R,6S)-tert-Butyl 2-(benzhydrylcarbamoyl)-6-methylmorpholine-4-carboxylate
期刊论文
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 卷号: 67, 页码: O1437-U897
作者:
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
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