Dezocine as a potent analgesic: overview of its pharmacological characterization

doi:10.1038/s41401-021-00790-6

	Dezocine as a potent analgesic: overview of its pharmacological characterization
	Ye, Rong-Rong 1,2; Jiang, Shuang 2,3; Xu, Xu 1; Lu, Yan 1; Wang, Yu-Jun 2; Liu, Jing-Gen 2
刊名	ACTA PHARMACOLOGICA SINICA
	2021-11-04
页码	12
关键词	dezocine opioid receptors norepinephrine serotonin transporter postoperative pain anesthesia
ISSN号	1671-4083
DOI	10.1038/s41401-021-00790-6
通讯作者	Lu, Yan(luuyann@sit.edu.cn) ; Wang, Yu-Jun(yjwang@simm.ac.cn)
英文摘要	Dezocine, a synthetic opioid, introduced in 1970s as an analgesic, was redeveloped for relieving moderate to severe pain by Yangtze River Pharmaceutical Group in China in 2009. To date, dezocine occupies 45% of China's opioid analgesic market. Along with dezocine being a dominated painkiller, a certain amount of research was conducted to elucidate dezocine's action. In this review we summarize the current knowledge on the receptor, preclinical and clinical pharmacology of dezocine. Briefly, preclinical data show that dezocine is effective under varying pain conditions, particularly chronic neuropathic pain and cancer pain, through activation of opioid receptors, and inhibition of norepinephrine reuptake. Clinical data establish the effectiveness of dezocine either as a primary analgesic for postoperative pain management or a supplement for balanced analgesia. The receptor profile of dezocine is different from known pure mu agonists, and allows it to be used in combination with other opioids for additivity in efficacy or lower incidence of adverse effects.
资助项目	National Natural Science Foundation of China[81671322] ; National Natural Science Foundation of China[81773710] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2017334]
WOS关键词	GENERAL-ANESTHESIA INDUCTION ; FENTANYL-INDUCED COUGH ; DOUBLE-BLIND ; POSTOPERATIVE ANALGESIA ; INTRAVENOUS ANALGESIA ; NEUROPATHIC PAIN ; INJECTION PAIN ; PROPOFOL ; MORPHINE ; ANTINOCICEPTION
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	NATURE PUBL GROUP
WOS记录号	WOS:000714525800005
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/298771]
专题	中国科学院上海药物研究所
通讯作者	Lu, Yan; Wang, Yu-Jun
作者单位	1.Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 201418, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
推荐引用方式 GB/T 7714	Ye, Rong-Rong,Jiang, Shuang,Xu, Xu,et al. Dezocine as a potent analgesic: overview of its pharmacological characterization[J]. ACTA PHARMACOLOGICA SINICA,2021:12.
APA	Ye, Rong-Rong,Jiang, Shuang,Xu, Xu,Lu, Yan,Wang, Yu-Jun,&Liu, Jing-Gen.(2021).Dezocine as a potent analgesic: overview of its pharmacological characterization.ACTA PHARMACOLOGICA SINICA,12.
MLA	Ye, Rong-Rong,et al."Dezocine as a potent analgesic: overview of its pharmacological characterization".ACTA PHARMACOLOGICA SINICA (2021):12.