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科研机构
上海药物研究所 [27]
内容类型
期刊论文 [27]
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2021 [2]
2018 [1]
2016 [5]
2014 [7]
2013 [1]
2012 [1]
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Histamine activates HinK to promote the virulence of Pseudomonas aeruginosa
期刊论文
SCIENCE BULLETIN, 2021, 卷号: 66, 期号: 11, 页码: 1101-1118
作者:
Wang, Yaya
;
Cao, Qiao
;
Cao, Qin
;
Gan, Jianhua
;
Sun, Ning
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/08/17
Pseudomonas aeruginosa
Histamine
Metabolism
Host-microbe interaction
Virulence
Discovery of MTR-106 as a highly potent G-quadruplex stabilizer for treating BRCA-deficient cancers
期刊论文
INVESTIGATIONAL NEW DRUGS, 2021, 页码: 9
作者:
Li, Meng-Zhu
;
Meng, Tao
;
Song, Shan-Shan
;
Bao, Xu-Bin
;
Ma, Lan-Ping
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2021/05/24
G-quadruplex stabilizer
MTR-106
BRCA-deficiency
PARP inhibitor
DNA damage
Straightforward Synthesis of Novel Difluorinated 2-Hydroxyl-Substituted Dihydroquinolones Through Selectfluor-triggered Annulation of 2-Aminoarylenaminones
期刊论文
CHEMISTRYSELECT, 2018, 卷号: 3, 期号: 32, 页码: 9218-9221
作者:
Zhao, Qing-Lan
;
Xiang, Hao-Yue
;
Yang, Chun-Hao
;
Xiao, Jun-An
;
Xia, Peng-Ju
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
annulation
cyclization
difluorinated
domino reactions
quinolone
Identification and Structural Characterization of Acylgluconic Acids, Flavonol Glycosides, Limonoids and Alkaloids from the Fruits of Evodia Rutaecarpa by High Performance Liquid Chromatography Coupled to Electrospray Ionization and Quadrupole Time-of-Flight Mass Spectrometry
期刊论文
JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2016, 卷号: 54, 期号: 9, 页码: 1593-1604
作者:
Ling, Yun
;
Hu, Pei
;
Zhang, Lifang
;
Jin, Hongguang
;
Chen, Jian
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
Structure-based optimization and derivatization of 2-substituted quinolone-based non-nucleoside HCV NS5B inhibitors with submicromolar cellular replicon potency
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 期号: 12, 页码: 2900-2906
作者:
Cheng, Yu
;
Shen, Jian
;
Peng, Run-Ze
;
Wang, Gui-Feng
;
Zuo, Jian-Ping
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
HCV NS5B polymerase
2-Alkyl quinolone
1,6-Naphthyridine-4,5-dione
Non-nucleoside inhibitor
Direct acting antiviral
Allosteric site
Design and synthesis of novel benzo[d]oxazol-2(3H)-one derivatives bearing 7-substituted-4-enthoxyquinoline moieties as c-Met kinase inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 115, 页码: 191-200
作者:
Lu, Dong
;
Shen, Aijun
;
Liu, Yang
;
Peng, Xia
;
Xing, Weiqiang
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
c-Met
Benzo[d]oxazol-2(3H)-one-quinolone
Molecular hybridization
Anti-cancer
Effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in healthy Chinese volunteers
期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2016, 卷号: 10, 页码: 357-370
作者:
Zhang, Yi-fan
;
Dai, Xiao-jian
;
Yang, Yong
;
Chen, Xiao-yan
;
Wang, Ting
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
nemonoxacin
probenecid
cimetidine
clinical pharmacokinetics
drug-drug interaction
Chronic administration of caderofloxacin, a new fluoroquinolone, increases hepatic CYP2E1 expression and activity in rats
期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 4, 页码: 561
作者:
Liu Li
;
Miao Mingxing
;
Zhong Zeyu
;
Xu Ping
;
Chen Yang
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2020/12/24
VIVO ANTIBACTERIAL ACTIVITIES
DRUG-DRUG INTERACTIONS
HUMAN LIVER-MICROSOMES
IN-VIVO
CYTOCHROME-P450 ENZYMES
HEALTHY-VOLUNTEERS
COCKTAIL APPROACH
METABOLISM
QUINOLONE
CS-940
caderofloxacin
cocktail approach
chlorzoxazone
CYP2E1
pharmacokinetics
drug-drug interaction
Effects of an Al3+- and Mg2+-containing antacid, ferrous sulfate, and calcium carbonate on the absorption of nemonoxacin (TG-873870) in healthy Chinese volunteers
期刊论文
ACTA PHARMACOLOGICA SINICA, 2014, 卷号: 35, 期号: 12, 页码: 1586-1592
作者:
Zhang, Yi-fan
;
Dai, Xiao-jian
;
Wang, Ting
;
Chen, Xiao-yan
;
Liang, Li
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
nemonoxacin
nonfluorinated quinolone
drug-drug interaction
antacid
ferrous sulfate
calcium carbonate
drug absorption
clinical pharmacokinetics
2-Aryl-3-carbonylquinolones: Design, Synthesis and Biological Evaluation of Novel HCV NS5B Polymerase Inhibitors
期刊论文
ACTA CHIMICA SINICA, 2014, 卷号: 72, 期号: 8, 页码: 906-913
作者:
Wang Shenfeng
;
Lin Jianping
;
He Peilan
;
Zuo Jianping
;
Long Yaqiu
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
HCV NS5B polymerase
2-substituted quinolone-3-carboxylic acid
non-nucleoside inhibitor
direct acting antiviral
allosteric site
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