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科研机构
上海药物研究所 [17]
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期刊论文 [17]
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2021 [1]
2020 [1]
2018 [3]
2017 [1]
2013 [2]
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Chemistry [1]
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专题:上海药物研究所
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Small-molecule fluorescence-based probes for interrogating major organ diseases
期刊论文
CHEMICAL SOCIETY REVIEWS, 2021, 页码: 39
作者:
Han, Hai-Hao
;
Tian, He, Jr.
;
Zang, Yi
;
Sedgwick, Adam C.
;
Li, Jia
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2021/08/17
Recent advances in dopaminergic strategies for the treatment of Parkinson's disease
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 12
作者:
Mao, Qi
;
Qin, Wang-zhi
;
Zhang, Ao
;
Ye, Na
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
Parkinson's disease
dopamine
D-1 receptor
D-2 receptor
allosteric modulator
neuroprotection
multitarget
drug discovery and development
neurodegenerative diseases
Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer's Disease Agents
期刊论文
ACS chemical neuroscience, 2018
作者:
Xu, Yixiang
;
Zhang, Jian
;
Wang, Huan
;
Mao, Fei
;
Bao, Keting
收藏
  |  
浏览/下载:84/0
  |  
提交时间:2019/01/08
Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 2, 页码: 328-345
作者:
Mao, Fei
;
Wang, Huan
;
Ni, Wei
;
Zheng, Xinyu
;
Wang, Manjiong
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2019/01/08
Alzheimer's disease
drug repositioning
dual-target inhibitor
AChE inhibition
PDE5 inhibition
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 143, 页码: 33-47
作者:
Xu, Yi-xiang
;
Wang, Huan
;
Li, Xiao-kang
;
Dong, Sheng-nan
;
Liu, Wen-wen
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
Multifunctional agents
AChE inhibitors
MAO-B inhibitors
Metal chelating agents
Alzheimer's disease
Research advances in non-P450-mediated drug oxidative metabolism
期刊论文
Acta Pharmaceutica Sinica, 2017, 卷号: 52, 期号: 1, 页码: 8-18
作者:
Zhou Lei
;
Zhong Dafang
;
Chen Xiaoyan
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
flavin-containing monooxygenase
monoamine oxidase
aldehyde oxidase
xanthine oxidase
alcohol dehydrogenase
aldehyde dehydrogenase
oxidative metabolism
Synthesis and biological evaluation of novel benzoxazinyl-oxazolidinones as potential antibacterial agents
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 卷号: 23, 期号: 13, 页码: 3697-3699
作者:
Guo, Bin
;
Fan, Houxing
;
Xin, Qisheng
;
Chu, Wenjing
;
Wang, Hui
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Benzoxazinyl-oxazolidinone
Linezolid
Antibacterial agents
Gram-positive organisms
Structural Analysis of a Novel Cyclohexylamine Oxidase from Brevibacterium oxydans IH-35A
期刊论文
PLOS ONE, 2013, 卷号: 8, 期号: 3
作者:
Mirza, I. Ahmad
;
Burk, David L.
;
Xiong, Bing
;
Iwaki, Hiroaki
;
Hasegawa, Yoshie
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Effects of Puerariae Radix Extract on Endotoxin Receptors and TNF-alpha Expression Induced by Gut-Derived Endotoxin in Chronic Alcoholic Liver Injury
期刊论文
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2012
作者:
Peng, Jing-Hua
;
Cui, Tuan
;
Sun, Zhao-Lin
;
Huang, Fu
;
Chen, Liang
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Catalytic Mechanism Investigation of Lysine-Specific Demethylase 1 (LSD1): A Computational Study
期刊论文
PLOS ONE, 2011, 卷号: 6, 期号: 9
作者:
Kong, Xiangqian
;
Ouyang, Sisheng
;
Liang, Zhongjie
;
Lu, Junyan
;
Chen, Liang
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
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