Research advances in non-P450-mediated drug oxidative metabolism

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	Research advances in non-P450-mediated drug oxidative metabolism
	Zhou Lei; Zhong Dafang; Chen Xiaoyan
刊名	Acta Pharmaceutica Sinica
	2017
卷号	52 期号:1 页码:8-18
关键词	flavin-containing monooxygenase monoamine oxidase aldehyde oxidase xanthine oxidase alcohol dehydrogenase aldehyde dehydrogenase oxidative metabolism
ISSN号	0513-4870
其他题名	非P450酶介导的药物氧化代谢研究进展
文献子类	Review
英文摘要	The major non-P450 enzymes involved in the oxidative metabolism of drugs are:the flavincontaining monooxygenase (FMO), the monoamine oxidase (MAO), the aldehyde oxidase (AO), the xanthine oxidase (XO), the alcohol dehydrogenase (ADH)and the aldehyde dehydrogenase (ALDH). In recent years, the role of non-P450 enzymes in drug oxidative metabolism has garnered increasing attention. However, the contribution of non-P450 enzymes to the drug oxidative metabolism is possibly underestimated in many cases, as most metabolism studies in drug discovery and lead optimization are conducted using in vitro test systems related to P450 enzymes. In this article, these non-P450 enzymes in terms of catalyzed reaction types, common substrates, gene polymorphism and drug interaction are reviewed, and the in vitro models and factors for non-P450-mediated oxidative metabolism are summarized. Similar to P450 enzymes, non-P450 enzymes can directly catalyze the oxidation of drugs, yielding therapeutically active metabolites or toxic metabolites. These enzymes can also oxidize the toxic metabolites, generated from P450-catalyzed reaction, to nontoxic metabolites. In general, most non-P450 enzymes (such as FMO and MAO)appear to be much less inducible than P450 enzymes.
资助项目	国家自然科学基金资助项目[00000000]
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:5902699
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/269218]
专题	上海药物代谢研究中心
通讯作者	Chen Xiaoyan
作者单位	Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式 GB/T 7714	Zhou Lei,Zhong Dafang,Chen Xiaoyan. Research advances in non-P450-mediated drug oxidative metabolism[J]. Acta Pharmaceutica Sinica,2017,52(1):8-18.
APA	Zhou Lei,Zhong Dafang,&Chen Xiaoyan.(2017).Research advances in non-P450-mediated drug oxidative metabolism.Acta Pharmaceutica Sinica,52(1),8-18.
MLA	Zhou Lei,et al."Research advances in non-P450-mediated drug oxidative metabolism".Acta Pharmaceutica Sinica 52.1(2017):8-18.