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科研机构
上海药物研究所 [282]
内容类型
期刊论文 [278]
会议论文 [2]
学位论文 [2]
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2021 [17]
2020 [21]
2019 [16]
2018 [29]
2017 [20]
2016 [18]
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Application of metabolomics for revealing the interventional effects of functional foods on metabolic diseases
期刊论文
FOOD CHEMISTRY, 2022, 卷号: 367, 页码: 14
作者:
Fu, Jia
;
Zhang, Le-Le
;
Li, Wei
;
Zhang, Yan
;
Zhang, Yamei
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2021/11/04
Functional foods
Metabolomics
Metabolites
Metabolic diseases
Food processing
Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Li, Teng-teng
;
Peng, Cheng
;
Wang, Ji-qiu
;
Xu, Zhi-jian
;
Su, Ming-bo
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2022/01/18
DPP4
distal mutation
enzymatic activity
molecular dynamics simulation
structure-function mechanism
New monoamine antidepressant, hypidone hydrochloride (YL-0919), enhances the excitability of medial prefrontal cortex in mice via a neural disinhibition mechanism
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Zhang, Yong-Mei
;
Ye, Lu-Yu
;
Li, Tian-Yu
;
Guo, Fan
;
Guo, Fei
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/01/04
YL-0919
medial prefrontal cortex
GABAergic neurons
5-HT1A receptor
GAD67-GFP transgenic mice
disinhibition
fluoxetine
electrophysiological recording
Huangjinsan ameliorates adenine-induced chronic kidney disease by regulating metabolic profiling
期刊论文
JOURNAL OF SEPARATION SCIENCE, 2021, 页码: 11
作者:
Guo, Yuejiao
;
Liu, Fang
;
Chen, MingCang
;
Tian, Qiang
;
Tian, Xiaoting
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/12/16
chronic kidney disease
Huangjinsan
metabolomics
renoprotection
traditional Chinese medicine
Constitutive signal bias mediated by the human GHRHR splice variant 1
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 40, 页码: 10
作者:
Cong, Zhaotong
;
Zhou, Fulai
;
Zhang, Chao
;
Zou, Xinyu
;
Zhang, Huibing
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/12/01
class B1 GPCR
receptor bias
cancer
cell proliferation
Structural insights into ligand recognition and activation of the melanocortin-4 receptor
期刊论文
CELL RESEARCH, 2021, 页码: 13
作者:
Zhang, Huibing
;
Chen, Li-Nan
;
Yang, Dehua
;
Mao, Chunyou
;
Shen, Qingya
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2021/11/04
Insights into Optical Probes Based on Aggregation-Induced Emission: from Restriction of Intramolecular Motions to Dark State
期刊论文
ADVANCED OPTICAL MATERIALS, 2021, 页码: 9
作者:
Huang, Shuai
;
Ding, Jipeng
;
Bi, Anyao
;
Yu, Kunqian
;
Zeng, Wenbin
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2021/11/04
aggregation-induced emission
dark state
optical probes
restriction of intramolecular motions
Molecular simulation studies of the interactions between the human/ pangolin/cat/bat ACE2 and the receptor binding domain of the SARS-CoV-2 spike protein
期刊论文
BIOCHIMIE, 2021, 卷号: 187, 页码: 1-13
作者:
Ma, Shaojie
;
Li, Hui
;
Yang, Jun
;
Yu, Kunqian
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2021/08/17
SARS-CoV-2
ACE2
Molecular simulation
Binding energy
Animal hosts
Supramolecular Antagonists Promote Mitochondrial Dysfunction
期刊论文
NANO LETTERS, 2021, 卷号: 21, 期号: 13, 页码: 5730-5737
作者:
Li, Mingming
;
Song, Yanqiu
;
Song, Na
;
Wu, Guangyao
;
Zhou, Hao
收藏
  |  
浏览/下载:87/0
  |  
提交时间:2021/08/17
Self-Assembly
Peptides
Drug Delivery
Mitochondrion-Targeting
Antagonists
Discovery, Structure-Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 13, 页码: 9458-9483
作者:
Huang, Huoming
;
Li, Xueping
;
Xie, Peng
;
Li, Xinwei
;
Xu, XueJun
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/08/17
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