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科研机构
上海药物研究所 [190]
内容类型
期刊论文 [187]
会议论文 [3]
发表日期
2021 [9]
2020 [12]
2019 [10]
2018 [20]
2017 [18]
2016 [18]
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Pharmacolo... [5]
Chemistry [3]
Biochemist... [2]
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Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 13
作者:
Meng, Xiang-Dong
;
Gao, Li-Xin
;
Wang, Zhi-Jia
;
Feng, Bo
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2021/12/01
2,5-diphenyl-1,3,4-oxadiazole derivatives
SHP2
Inhibitors
Structure-activity relationships (SAR)
Picomolar antimalarial agent from a Chinese medicinal plant
期刊论文
SCIENCE CHINA-CHEMISTRY, 2021, 页码: 5
作者:
Zhou, Bin
;
Zimbres, Flavia M.
;
Butler, Joshua H.
;
Xu, Cheng-Hui
;
Haney, Reagan S.
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2021/12/01
medicinal plants
dimeric sesquiterpenoids
antimalarial agent
structure-activity relationship
TANK-binding kinase 1 (TBK1): An emerging therapeutic target for drug discovery
期刊论文
DRUG DISCOVERY TODAY, 2021, 卷号: 26, 期号: 10, 页码: 2445-2455
作者:
Xiang, Shuang
;
Song, Shukai
;
Tang, Haotian
;
Smaill, Jeff B.
;
Wang, Aiqun
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  |  
浏览/下载:23/0
  |  
提交时间:2021/12/01
Antibiotic resistance
Computational biology
Databases
In silico tools
Structural optimization and biological evaluation for novel artemisinin derivatives against liver and ovarian cancers
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 13
作者:
Zhou, Yu
;
Li, Xiaoguang
;
Chen, Kerong
;
Ba, Qian
;
Zhang, Xu
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  |  
浏览/下载:38/0
  |  
提交时间:2021/06/11
Structural optimization
Lead compound
Artemisinin derivatives
Cancer
Structural optimization and biological evaluation for novel artemisinin derivatives against liver and ovarian cancers
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 13
作者:
Zhou, Yu
;
Li, Xiaoguang
;
Chen, Kerong
;
Ba, Qian
;
Zhang, Xu
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2021/05/24
Structural optimization
Lead compound
Artemisinin derivatives
Cancer
In Vivo Efficacy and Metabolism of the Antimalarial Cycleanine and Improved In Vitro Antiplasmodial Activity of Semisynthetic Analogues
期刊论文
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021, 卷号: 65, 期号: 2, 页码: 11
作者:
Uche, Fidelia Ijeoma
;
Guo, Xiaozhen
;
Okokon, Jude
;
Ullah, Imran
;
Horrocks, Paul
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  |  
浏览/下载:26/0
  |  
提交时间:2021/05/24
malaria
Plasmodium falciparum
Plasmodium berghei
bisbenzylisoquinoline alkaloids
cycleanine
metabolism
in vivo activity
antimalarial agents
drug metabolism
Nosiheptide analogues as potential antibacterial agents via dehydroalanine region modifications: Semi-synthesis, antimicrobial activity and molecular docking study
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 31, 页码: 10
作者:
Fan, Yafei
;
Chen, Hangfei
;
Mu, Ning
;
Wang, Wengui
;
Zhu, Kongkai
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  |  
浏览/下载:20/0
  |  
提交时间:2021/05/24
Nosiheptide analogues
Semi-synthesis
Antimicrobial activity
Molecular docking
Fluorescent probes for the imaging of lipid droplets in live cells
期刊论文
COORDINATION CHEMISTRY REVIEWS, 2021, 卷号: 427, 页码: 14
作者:
Tian, He, Jr.
;
Sedgwick, Adam C.
;
Han, Hai-Hao
;
Sen, Sajal
;
Chen, Guo-Rong
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  |  
浏览/下载:128/0
  |  
提交时间:2021/05/24
Lipid droplets (LDs)
Fluorescent probes
Intramolecular charge transfer (ICT)
Aggregation-induced emission (AIE)
Cellular imaging
Synthesis of new derivatives of alepterolic acid via click chemistry
期刊论文
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 2021, 卷号: 86, 期号: 10, 页码: 917-925
作者:
Jin, X. I. N.
;
Cao, Jianguo
;
Zhao, Qingjie
;
Wang, Qi
;
Guo, Hongmei
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  |  
浏览/下载:6/0
  |  
提交时间:2021/11/04
diterpenoid
1,2,3-triazole
structural modification
A new method for the synthesis of chalcone derivatives promoted by PPh3/I(2)under non-alkaline conditions
期刊论文
SYNTHETIC COMMUNICATIONS, 2020, 页码: 10
作者:
Xue, Kangsheng
;
Sun, Guoxiang
;
Zhang, Yanzhi
;
Chen, Xubing
;
Zhou, Yang
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  |  
浏览/下载:21/0
  |  
提交时间:2020/12/24
Aldehyde
chalcone
Claisen-Schmidt reaction
ketone
PPh3
I2
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