Synthesis of new derivatives of alepterolic acid via click chemistry

doi:10.2298/JSC210316045J

	Synthesis of new derivatives of alepterolic acid via click chemistry
	Jin, X. I. N.2,5; Cao, Jianguo 1; Zhao, Qingjie 3; Wang, Qi 1; Guo, Hongmei 2,5; Aisa, Haji Akber 2; Huang, Guozheng 2,4
刊名	JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
	2021
卷号	86 期号:10 页码:917-925
关键词	diterpenoid 1,2,3-triazole structural modification
ISSN号	0352-5139
DOI	10.2298/JSC210316045J
通讯作者	Aisa, Haji Akber(haji@ms.xjb.ac.cn) ; Huang, Guozheng(guozheng.huang@ahut.edu.cn)
英文摘要	Alepterolic acid is a natural diterpenoid isolated from Aleuritopteris argentea (S. G. Gmel.) Fee, a fern with potential medicinal activity, used in China as a folk medicine to regulate menstruation and prevent cancer. Nevertheless, there are few reports about the structural modification of this natural product. With the wide application of 1,2,3-triazole derivatives in medicines, pesticides, functional materials, the synthesis of 1,2,3-triazoles derivatives has attracted the attention of synthetic chemists. In this article, 23 new derivatives of alepterolic acid combined with 1,2,3-triazole were designed and synthesized by esterification and click chemistry reaction in a fast, conventional and efficient way. All the products were obtained in good yields (72 to 97 %). The structure of these compounds was confirmed by H-1-, C-13-NMR and mass spectral data. The use of the easily available reactants and the common reaction conditions furnish an efficient method for the synthesis of alepterolic acid derivatives. The preparation of these compounds would enable further biological evaluation in the future.
资助项目	Anhui University of Technology ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040322]
WOS关键词	1,2,3-TRIAZOLES ; CYCLOADDITION ; DESIGN ; AGENTS
WOS研究方向	Chemistry
语种	英语
出版者	SERBIAN CHEMICAL SOC
WOS记录号	WOS:000701832600002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/297449]
专题	中国科学院上海药物研究所
通讯作者	Aisa, Haji Akber; Huang, Guozheng
作者单位	1.Shanghai Normal Univ, Coll Life Sci, Shanghai 201418, Peoples R China 2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 4.Anhui Univ Technol, Coll Chem & Chem Engn, Maanshan 243002, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Jin, X. I. N.,Cao, Jianguo,Zhao, Qingjie,et al. Synthesis of new derivatives of alepterolic acid via click chemistry[J]. JOURNAL OF THE SERBIAN CHEMICAL SOCIETY,2021,86(10):917-925.
APA	Jin, X. I. N..,Cao, Jianguo.,Zhao, Qingjie.,Wang, Qi.,Guo, Hongmei.,...&Huang, Guozheng.(2021).Synthesis of new derivatives of alepterolic acid via click chemistry.JOURNAL OF THE SERBIAN CHEMICAL SOCIETY,86(10),917-925.
MLA	Jin, X. I. N.,et al."Synthesis of new derivatives of alepterolic acid via click chemistry".JOURNAL OF THE SERBIAN CHEMICAL SOCIETY 86.10(2021):917-925.