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科研机构
上海药物研究所 [17]
内容类型
期刊论文 [15]
会议论文 [1]
学位论文 [1]
发表日期
2021 [1]
2020 [3]
2018 [2]
2014 [1]
2011 [1]
2009 [1]
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Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Zhou, Yu-bo
;
Zhang, Yang-ming
;
Huang, Hong-hui
;
Shen, Li-jing
;
Han, Xiao-feng
收藏
  |  
浏览/下载:93/0
  |  
提交时间:2021/11/04
multiple myeloma
HDAC inhibitor
bisthianostat
pharmacodynamics
pharmacokinetics
phase 1a clinical trial
antitumor drug
Phase I dose-escalation and expansion study of PARP inhibitor, fluzoparib (SHR3162), in patients with advanced solid tumors
期刊论文
CHINESE JOURNAL OF CANCER RESEARCH, 2020, 卷号: 32, 期号: 3, 页码: 370-+
作者:
Li, Huiping
;
Liu, Rongrui
;
Shao, Bin
;
Ran, Ran
;
Song, Guohong
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/12/24
Phase I
PARP inhibitor (fluzoparib)
solid tumor
pharmacokinetics
safety
antitumor activity
Dipeptidyl peptidase 4 inhibitor sitagliptin protected against dextran sulfate sodium-induced experimental colitis by potentiating the action of GLP-2
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11
作者:
Ning, Meng-meng
;
Yang, Wen-ji
;
Guan, Wen-bo
;
Gu, Yi-pei
;
Feng, Ying
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/01
ulcerative colitis
dextran sulfate sodium
dipeptidyl peptidase 4
sitagliptin
glucagon-like peptide-2
GLP-2(3-33)
apoptosis
proliferation
Design, synthesis, and biological evaluation of 1,2,5-oxadiazole-3-carboximidamide derivatives as novel indoleamine-2,3-dioxygenase 1 inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 189, 页码: 14
作者:
Song, Xiaohan
;
Sun, Pu
;
Wang, Jiang
;
Guo, Wei
;
Wang, Yi
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/07/01
IDO1 inhibitors
Immunotherapy
Anti-Tumor
Humanin decreases mitochondrial membrane permeability by inhibiting the membrane association and oligomerization of Bax and Bid proteins
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 6, 页码: 1012-1021
作者:
Ma, Ze-wei
;
Liu, Dong-xiang
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
Alzheimer's disease
humanin
Bcl-2 family
mitochondrial outer membrane
single-molecule fluorescence
humanindecreasesmitochondrialmembranepermeabilitybyinhibitingthemembraneassociationandoligomerizationofbaxandbidproteins
期刊论文
actapharmacologicasinica, 2018, 卷号: 039, 期号: 006, 页码: 1012
作者:
Ma Zewei
;
Liu Dongxiang
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  |  
浏览/下载:43/0
  |  
提交时间:2020/07/01
Bax
膜渗透
蛋白质
协会
apoptosis
类脂化合物
单个分子
细胞色素
A phase I study of AST1306, a novel irreversible EGFR and HER2 kinase inhibitor, in patients with advanced solid tumors
期刊论文
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2014, 卷号: 7
作者:
Zhang, Jian
;
Cao, Junning
;
Li, Jin
;
Zhang, Yifan
;
Chen, Zhiyu
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  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
AST1306
ErbB family
Irreversible tyrosine kinase inhibitor
Phase I
Comparison the pharmacokinetics of tacrolimus in Chinese kidney transplant pa-tients after repeated-dose of modified release and immediate release preparations
期刊论文
The Chinese Journal of Clinical Pharmacology, 2011, 卷号: 27, 期号: 9, 页码: 696-700
作者:
ZHANG Yi-fan
;
CHEN Xiao-yan
;
DAI Xiao-jian
;
AO Jian-hua
;
ZHONG Da-fang
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
modified release tacrolimus
pharmacokinetics
kidney transplantation
GA3, a new gambogic acid derivative, exhibits potent antitumor activities in vitro via apoptosis-involved mechanisms
期刊论文
ACTA PHARMACOLOGICA SINICA, 2009, 卷号: 30, 期号: 3, 页码: 346-354
作者:
Xie, Hua
;
Qin, Yu-xin
;
Zhou, Yun-long
;
Tong, Lin-jiang
;
Lin, Li-ping
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
gambogic acid
GA3
antitumor
apoptosis
caspase
Bcl-2
cytochrome c
Effect of rf/-tetrahydropalmatine on rat gastric ulcer
期刊论文
Chinese Pharmaceutical Journal, 2005, 卷号: 40, 期号: 12, 页码: 902-904
作者:
Zhang Zhongmiao
;
Geng Baoqin
;
Yong Dingguo
;
Jin GuoZhang
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
dl-四氢巴马汀
胃溃疡
胃酸
胃蛋白酶
胃黏膜血流
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