Effect of rf/-tetrahydropalmatine on rat gastric ulcer

	Effect of rf/-tetrahydropalmatine on rat gastric ulcer
	Zhang Zhongmiao 2; Geng Baoqin 3; Yong Dingguo 3; Jin GuoZhang1
刊名	Chinese Pharmaceutical Journal
	2005
卷号	40 期号:12 页码:902-904
关键词	dl-四氢巴马汀胃溃疡胃酸胃蛋白酶胃黏膜血流
ISSN号	1001-2494
其他题名	dl-四氢巴马汀抗大鼠胃溃疡作用
文献子类	Article
英文摘要	To study the effect of rfl-tetrahydropalmatine (dl-THP) on various rat gastric ulcers and analyze its possible mechanism.METHODS The gastric mucosal damage was induced by pyloric ligation, restraint, indomethacin and acetic acid in rats, dl-THP 15, 30 and 45 mg'kg" ' was given ig bid for 5 doses. Then the number of gastric ulcers or the gastric ulcer area, the secretion of gastric juice, hydrochloric acid and pepsin activity were determined respectively.The stomach blood flow in normal and dl-THP treated rats was also examined.RESULTS dl-THP 15,30,45 mg*kg~ ' protected the gastric mucosa against the damages with a dose-dependent manner. In chronic gastric ulcer model, the inhibitory rates of gastric ulcer of dl-THP and ranitidine 30 mg'kg were 75.8% and 67.7% , respectively. However, the secretions of gastric juice, HC1, and pepsin by gastric mucosa were not influenced by dl-THP. Moreover, rf/-THP increased stomach blood flow significantly.CONCLUSION (//-THP protected various experimental gastric ulcers by increasing stomach blixxl flow and maybe partly by antagonizing gastric DA receptors.
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:2148576
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/268301]
专题	院士及顾问专家
作者单位	1.Shanghai Institute of Material Medical, Chinese Academy of Sciences, Shanghai 200032, China. 2.Department of Phamuu:y, Second Affiliated Hospital, Medical School of Zhejiang University, Hangzhou, Zhejiang 310009, China.; 3.Department of Pharmacology, Medical School of Zhejiang University, Hangzhou, Zhejiang 310031, China.;
推荐引用方式 GB/T 7714	Zhang Zhongmiao,Geng Baoqin,Yong Dingguo,et al. Effect of rf/-tetrahydropalmatine on rat gastric ulcer[J]. Chinese Pharmaceutical Journal,2005,40(12):902-904.
APA	Zhang Zhongmiao,Geng Baoqin,Yong Dingguo,&Jin GuoZhang.(2005).Effect of rf/-tetrahydropalmatine on rat gastric ulcer.Chinese Pharmaceutical Journal,40(12),902-904.
MLA	Zhang Zhongmiao,et al."Effect of rf/-tetrahydropalmatine on rat gastric ulcer".Chinese Pharmaceutical Journal 40.12(2005):902-904.