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科研机构
合肥物质科学研究院 [12]
内容类型
期刊论文 [12]
发表日期
2023 [2]
2022 [3]
2021 [2]
2019 [2]
2018 [2]
2016 [1]
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内容类型:期刊论文
专题:合肥物质科学研究院
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Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy
期刊论文
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13
作者:
Hua, Chen
;
Shena, Lijuan
;
Zoua, Fengming
;
Wua, Yun
;
Wanga, Beilei
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/11/10
Acquired resistance mutations
CDK9 inhibitors
Transcription
Single nucleotide polymorphisms
BAY1251152
Proteomics Analysis Revealed Smad3 as a Potential Target of the Synergistic Anti-tumor Activity of Disulfiram and Cisplatin in Ovarian Cancer
期刊论文
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2023, 卷号: 23
作者:
Du, Ruiping
;
Sun, Feilong
;
Li, Kai
;
Qi, Jian
;
Zhong, Wen
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2023/11/10
Disulfiram
cisplatin resistance
ovarian cancer
proteomics analysis
SMAD3
lactate dehydrogenase
The reversal of anti-HER2 resistance in advanced HER2-positive breast cancer using apatinib: two cases reports and literature review
期刊论文
TRANSLATIONAL CANCER RESEARCH, 2022
作者:
He, Libin
;
Shen, Xiabo
;
Liu, Yiyuan
;
Gao, Lu
;
Wu, Jiayi
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/12/23
Advanced human epidermal growth factor receptor 2-positive breast cancer (advanced HER2-positive breast cancer)
apatinib
case report
Drug-resistant HER2-positive breast cancer: Molecular mechanisms and overcoming strategies
期刊论文
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13
作者:
Wu, Xiaofan
;
Yang, Hongjian
;
Yu, Xingfei
;
Qin, Jiang-Jiang
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2022/12/22
HER2
breast cancer
targeted therapy
drug resistance
overcoming strategies
Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in China
期刊论文
THORACIC CANCER, 2022
作者:
Xu, Chunwei
;
Si, Lu
;
Wang, Wenxian
;
Li, Ziming
;
Song, Zhengbo
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/12/22
fusion
precision medicine
solid tumor
targeted therapy
tyrosine receptor kinase
Discovery of a highly potent kinase inhibitor capable of overcoming multiple imatinib-resistant ABL mutants for chronic myeloid leukemia (CML)
期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2021, 卷号: 897
作者:
Lu, Tingting
;
Cao, Jiangyan
;
Zou, Fengming
;
Li, Xixiang
;
Wang, Aoli
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  |  
浏览/下载:42/0
  |  
提交时间:2021/04/26
BCR-ABL
ABL mutants
Chronic myeloid leukemia
Kinase inhibitor
Imatinib resistance
Out-of-the-Box Nanocapsules Packed with On-Demand Hydrophobic Anticancer Drugs for Lung Targeting, Esterase Triggering, and Synergy Therapy
期刊论文
ADVANCED HEALTHCARE MATERIALS, 2021
作者:
Zhao, Di
;
Jiang, Kai
;
Wang, Yuqi
;
Cheng, Jin
;
Mo, Fangli
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  |  
浏览/下载:122/0
  |  
提交时间:2021/03/15
controllable esterase response
high loading efficiency
lung targeting
multi-drug resistance
universal drug encapsulation
Repurposing cabozantinib to GISTs: Overcoming multiple imatinib-resistant cKIT mutations including gatekeeper and activation loop mutants in GISTs preclinical models
期刊论文
CANCER LETTERS, 2019, 页码: 105-114
作者:
Lu, Tingting
;
Chen, Cheng
;
Wang, Aoli
;
Jiang, Zongru
;
Qi, Ziping
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  |  
浏览/下载:12/0
  |  
提交时间:2020/07/14
cKIT T670I mutant
Activation loop mutants
Drug resistance
Targeting slug-mediated non-canonical activation of c-Met to overcome chemo-resistance in metastatic ovarian cancer cells
期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9
-
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  |  
浏览/下载:5/0
  |  
提交时间:2020/10/26
EPITHELIAL-MESENCHYMAL TRANSITION
TUMOR-GROWTH
HETEROGENEITY
AMPLIFICATION
CONTRIBUTES
PROGRESSION
CARCINOMA
REVEALS
PATHWAY
SNAIL
Slug
c-Met
Drug resistance
Ovarian cancer
XL184
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
作者:
Liu, Xuesong
;
Wang, Beilei
;
Chen, Cheng
;
Jiang, Zongru
;
Hu, Chen
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/11
ABL kinase
Kinase inhibitor
ABL mutant
CML
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