Drug-resistant HER2-positive breast cancer: Molecular mechanisms and overcoming strategies

doi:10.3389/fphar.2022.1012552

	Drug-resistant HER2-positive breast cancer: Molecular mechanisms and overcoming strategies
	Wu, Xiaofan; Yang, Hongjian; Yu, Xingfei; Qin, Jiang-Jiang
刊名	FRONTIERS IN PHARMACOLOGY
	2022-09-23
卷号	13
关键词	HER2 breast cancer targeted therapy drug resistance overcoming strategies
DOI	10.3389/fphar.2022.1012552
通讯作者	Yu, Xingfei(yuxf1177@zjcc.org.cn) ; Qin, Jiang-Jiang(jqin@ucas.ac.cn)
英文摘要	Breast cancer is one of the most common malignancies and the leading cause of cancer-related death in women. HER2 overexpression is a factor for poor prognosis in breast cancer, and anti-HER2 therapy improves survival in these patients. A dual-targeted combination of pertuzumab and trastuzumab, alongside cytotoxic chemotherapy, constitutes the primary treatment option for individuals with early-stage, HER2-positive breast cancer. Antibody-drug conjugate (ADC) and tyrosine kinase inhibitors (TKI) also increase the prognosis for patients with metastatic breast cancer. However, resistance to targeted therapy eventually occurs. Therefore, it is critical to investigate how HER2-positive breast cancer is resistant to targeted therapy and to develop novel drugs or strategies to overcome the resistance simultaneously. This review aims to provide a comprehensive discussion of the HER2-targeted agents currently in clinical practice, the molecular mechanisms of resistance to these drugs, and the potential strategies for overcoming resistance.
资助项目	Qiantang Cross Fundation ; Wu Jieping Medical Foundation[320.6750.2021-10-30] ; Project of Zhejiang Medical and Health Science and Technology Program[2020KY491]
WOS关键词	EPIDERMAL-GROWTH-FACTOR ; FACTOR RECEPTOR ; DOUBLE-BLIND ; TRASTUZUMAB RESISTANCE ; PI3K PATHWAY ; ANTIBODY ; HER2 ; PLACEBO ; GENE ; PERTUZUMAB
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000869974800001
资助机构	Qiantang Cross Fundation ; Wu Jieping Medical Foundation ; Project of Zhejiang Medical and Health Science and Technology Program
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/129478]
专题	中国科学院合肥物质科学研究院
通讯作者	Yu, Xingfei; Qin, Jiang-Jiang
作者单位	Univ Chinese Acad Sci, Zhejiang Canc Hosp, Inst Basic Med & Canc IBMC, Chinese Acad Sci,Canc Hosp, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Wu, Xiaofan,Yang, Hongjian,Yu, Xingfei,et al. Drug-resistant HER2-positive breast cancer: Molecular mechanisms and overcoming strategies[J]. FRONTIERS IN PHARMACOLOGY,2022,13.
APA	Wu, Xiaofan,Yang, Hongjian,Yu, Xingfei,&Qin, Jiang-Jiang.(2022).Drug-resistant HER2-positive breast cancer: Molecular mechanisms and overcoming strategies.FRONTIERS IN PHARMACOLOGY,13.
MLA	Wu, Xiaofan,et al."Drug-resistant HER2-positive breast cancer: Molecular mechanisms and overcoming strategies".FRONTIERS IN PHARMACOLOGY 13(2022).