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上海药物研究所 [10]
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期刊论文 [22]
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Oridonin inhibits DNMT3A R882 mutation-driven clonal hematopoiesis and leukemia by inducing apoptosis and necroptosis
期刊论文
CELL DEATH DISCOVERY, 2021, 卷号: 7, 期号: 1, 页码: 12
作者:
Liao, Min
;
Dong, Qiongye
;
Chen, Ruiqing
;
Xu, Liqian
;
Jiang, Yuxuan
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浏览/下载:33/0
  |  
提交时间:2021/12/01
5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 19
作者:
Wang, Shuni
;
Yang, Hong
;
Su, Mingbo
;
Lian, Fulin
;
Cong, Zhanqing
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  |  
浏览/下载:80/0
  |  
提交时间:2021/11/04
NSD2
Methyltransferase
HTS
Multiple myeloma
5-Aminonaphthalene derivatives
Inhibitor
Tunable and Contamination-Free Injection with Microfluidics by Stepinjection
期刊论文
ANALYTICAL CHEMISTRY, 2021, 卷号: 93, 期号: 39, 页码: 13112-13117
作者:
Hu, Beiyu
;
Ye, Shun
;
Chen, Dongwei
;
Xie, Bingliang
;
Hu, Ran
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  |  
浏览/下载:26/0
  |  
提交时间:2021/11/15
High-throughput screening of critical size of grain growth in gradient structured nickel
期刊论文
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY, 2021, 卷号: 82, 页码: 33-39
作者:
Lu, Yunli
;
Duan, Fenghui
;
Pan, Jie
;
Li, Yi
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  |  
浏览/下载:44/0
  |  
提交时间:2021/10/15
High-throughput
Gradient structure
Critical size
Grain growth
Thermal stablitiy
Prediction of the Liquid-Liquid Extraction Properties of Imidazolium-Based Ionic Liquids for the Extraction of Aromatics from Aliphatics
期刊论文
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2021, 卷号: 61, 期号: 7, 页码: 3376-3385
作者:
Yu, Tianhao
;
Olsson, Emilia
;
Lian, Guoping
;
Liu, Lei
;
Huo, Feng
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  |  
浏览/下载:26/0
  |  
提交时间:2021/08/31
Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 7
作者:
Wang, Yi
;
Fang, Sui
;
Wu, Yan
;
Cheng, Xi
;
Zhang, Lei-ke
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  |  
浏览/下载:102/0
  |  
提交时间:2021/08/17
SARS-CoV-2
envelope protein (2-E)
cation channel
high-throughput screening (HTS)
anti-virus
Identification of Novel Fused Heteroaromatics-Based MALT1 Inhibitors by High-Throughput Screening to Treat B Cell Lymphoma
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 13, 页码: 9217-9237
作者:
Liang, Xuewu
;
Sun, Chenxia
;
Li, Chunpu
;
Yu, Haolan
;
Wei, Xiaohui
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  |  
浏览/下载:20/0
  |  
提交时间:2021/08/17
Discovery of Novel Allosteric Modulators Targeting an Extra-Helical Binding Site of GLP-1R Using Structure- and Ligand-Based Virtual Screening
期刊论文
BIOMOLECULES, 2021, 卷号: 11, 期号: 7, 页码: 14
作者:
Zhou, Qingtong
;
Guo, Wanjing
;
Dai, Antao
;
Cai, Xiaoqing
;
Vass, Marton
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  |  
浏览/下载:41/0
  |  
提交时间:2021/08/17
GLP-1R
virtual screening
allosteric modulator
drug discovery
molecular docking
Histone deacetylase inhibitor givinostat alleviates liver fibrosis by regulating hepatic stellate cell activation
期刊论文
MOLECULAR MEDICINE REPORTS, 2021, 卷号: 23, 期号: 5, 页码: 12
作者:
Huang, He-Ming
;
Zhou, Xiao-Ru
;
Liu, Yan-Jun
;
Fan, Shi-Jie
;
Liao, Li-Ping
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  |  
浏览/下载:45/0
  |  
提交时间:2021/05/24
liver fibrosis
hepatic stellate cell
histone deacetylase inhibitor
epigenetics
givinostat
Design, synthesis and pharmacological evaluation of tricyclic derivatives as selective RXFP4 agonists
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 110, 页码: 17
作者:
Lin, Lin
;
Lin, Guangyao
;
Zhou, Qingtong
;
Bathgate, Ross A. D.
;
Gong, Grace Qun
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  |  
浏览/下载:31/0
  |  
提交时间:2021/08/17
Synthesis
Structure-activity relationship
Relaxin family peptide receptor 4
Selective agonist
Molecular docking
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