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浏览/检索结果: 共48条，第1-10条 帮助 限定条件 发表日期：2020    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Targeted Drugs for Treatment of Pulmonary Arterial Hypertension: Past, Present, and Future Perspectives 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 24, 页码: 15153-15186 作者:  Zheng, Wei;  Wang, Zhen;  Jiang, Xiangrui;  Zhao, Qingjie;  Shen, Jingshan 收藏  |  浏览/下载：26/0  |  提交时间：2021/05/24 A novel salviadione derivative, compound 15a, attenuates diabetes-induced renal injury by inhibiting NF-kappa B-mediated inflammatory responses 期刊论文 TOXICOLOGY AND APPLIED PHARMACOLOGY, 2020, 卷号: 409, 页码: 11 作者:  Li, Li;  Ding, Chunyong;  Zou, Chunpeng;  Xiong, Zhi;  Zhu, Weiwei 收藏  |  浏览/下载：98/0  |  提交时间：2021/05/24 Salviadione derivative 15a  Diabetic nephropathy  Inflammation  Macrophage infiltration  Fibrosis  Nuclear factor-kappa B  Cytokines   Further new complex daphniphyllum alkaloids from the stems and leaves of Daphniphyllum calycinum: Structure and stereochemistry 期刊论文 TETRAHEDRON, 2020, 卷号: 76, 期号: 49, 页码: 8 作者:  Shen, Shou-Mao;  Li, Heng;  Wang, Jian-Rong;  Zeng, Yan-Bo;  Guo, Yue-Wei 收藏  |  浏览/下载：19/0  |  提交时间：2020/12/24 Daphniphyllum calycinum  Daphniphyllum alkaloids  Absolute configuration   Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 22, 页码: 7 作者:  Bi, Xiaoyang;  Chen, Yu;  Sun, Zhongya;  Lu, Wenchao;  Xu, Pan 收藏  |  浏览/下载：21/0  |  提交时间：2021/05/24 Drug design  CBP  Bromodomain  Inhibitor  Acute myeloid leukemia   Discovery of Novel IDH1 Inhibitor Through Comparative Structure-Based Virtual Screening 期刊论文 FRONTIERS IN PHARMACOLOGY, 2020, 卷号: 11, 页码: 11 作者:  Wang, Yuwei;  Tang, Shuai;  Lai, Huanling;  Jin, Ruyi;  Long, Xu 收藏  |  浏览/下载：49/0  |  提交时间：2020/12/24 IDH1  gliomas  molecular docking  virtual screening  docking-based virtual screening   Synthesis and biological activity of C-7, C-9 and C-10 modified taxane analogues from 1-deoxybaccatin VI 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2020, 卷号: 28, 期号: 21, 页码: 8 作者:  Xie, Chenghu;  Cui, Yongmei;  Li, Lanlan;  Zhang, Minmin;  Liu, Hongchun 收藏  |  浏览/下载：74/0  |  提交时间：2020/12/21 Paclitaxel  Taxane analogues  1-Deoxybaccatin VI  Synthesis  In vitro anticancer activity   Activation of SIK1 by phanginin A inhibits hepatic gluconeogenesis by increasing PDE4 activity and suppressing the cAMP signaling pathway 期刊论文 MOLECULAR METABOLISM, 2020, 卷号: 41, 页码: 15 作者:  Liu, Siwen;  Huang, Suling;  Wu, Xingde;  Feng, Ying;  Shen, Yu 收藏  |  浏览/下载：55/0  |  提交时间：2020/12/24 Salt-inducible kinase 1  Phanginin A  Phosphodiesterase 4  Gluconeogenesis  cAMP   Structural basis for activation of the growth hormone-releasing hormone receptor 期刊论文 NATURE COMMUNICATIONS, 2020, 卷号: 11, 期号: 1, 页码: 10 作者:  Zhou, Fulai;  Zhang, Huibing;  Cong, Zhaotong;  Zhao, Li-Hua;  Zhou, Qingtong 收藏  |  浏览/下载：24/0  |  提交时间：2020/12/21 Automated design and optimization of multitarget schizophrenia drug candidates by deep learning 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 204, 页码: 16 作者:  Tan, Xiaoqin;  Jiang, Xiangrui;  He, Yang;  Zhong, Feisheng;  Li, Xutong 收藏  |  浏览/下载：36/0  |  提交时间：2020/12/21 Schizophrenia  Multitarget antipsychotic drugs  Recurrent neural network  Multitask deep neural network  Automated drug design   Rational Design and Evaluation of 6-(Pyrimidin-2-ylamino)-3,4-dihydroquinoxalin-2(1H)-ones as Polypharmacological Inhibitors of BET and Kinases 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 17, 页码: 9787-9802 作者:  Lv, Kaikai;  Chen, Weicong;  Chen, Danqi;  Mou, Jie;  Zhang, Huijie 收藏  |  浏览/下载：12/0  |  提交时间：2020/12/21