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上海药物研究所 [6]
湖南大学 [3]
西双版纳热带植物园 [2]
昆明植物研究所 [2]
南华大学 [1]
昆明医科大学 [1]
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期刊论文 [17]
发表日期
2019 [17]
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Pharmacolo... [2]
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Design, synthesis and biological evaluation of the thioether-containing lenalidomide analogs with anti-proliferative activities
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 176, 页码: 419-430
作者:
Xiao, Donghuai
;
Wang, Yu-jie
;
Hu, Xiao-bei
;
Kan, Wei-juan
;
Zhang, Qiumeng
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  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
Lenalidomide
Thioether
Anti-Tumor
Structural modification
Selective ERK1/2 agonists isolated from Melia azedarach with potent anti-leukemic activity
期刊论文
BMC Cancer, 2019, 卷号: 19, 期号: 1
作者:
Wang,Ning
;
Fan,Yanhua
;
Yuan,Chun-Mao
;
Song,Jialei
;
Yao,Yao
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  |  
浏览/下载:83/0
  |  
提交时间:2019/08/13
Cancer
Leukemia
Chinese medicinal plant
Melia azedarach
Drug screen
ERK1/2 agonists
Differentiation
Apoptosis
Rational Design, synthesis and biological evaluation of novel triazole derivatives as potent and selective PRMT5 inhibitors with antitumor activity
期刊论文
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2019, 卷号: 33, 期号: 8, 页码: 775-785
作者:
Zhu, Kongkai
;
Shao, Jingwei
;
Tao, Hongrui
;
Yan, Xue
;
Luo, Cheng
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  |  
浏览/下载:12/0
  |  
提交时间:2020/07/01
PRMT5 inhibitor
Anti-proliferative
Cellular target validation
Design and synthesis
Cytotoxic ergosteroids from the fungus Stereum hirsutum
期刊论文
PHYTOCHEMISTRY LETTERS, 2019, 卷号: 30, 页码: 143-149
作者:
Zhao, Zhen-Zhu
;
Han, Kai-Yue
;
Li, Zheng-Hui
;
Feng, Tao
;
Chen, He-Ping
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  |  
浏览/下载:55/0
  |  
提交时间:2019/04/15
Stereum hirsutum
Steroids
Semi-synthesis
Cytotoxicity
Discovery of Novel PRMT5 Inhibitors by Virtual Screening and Biological Evaluations
期刊论文
CHEMICAL & PHARMACEUTICAL BULLETIN, 2019, 卷号: 67, 期号: 4, 页码: 382-388
作者:
Tao, Hongrui
;
Yan, Xue
;
Zhu, Kongkai
;
Zhang, Hua
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  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
virtual screening
epigenetic inhibitor
antiproliferation
molecular docking
Exploration of novel macrocyclic dipeptide N-benzyl amides as proteasome inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 164, 页码: 423-439
作者:
Yu, Jianjun
;
Liu, Jieyu
;
Li, Daqiang
;
Xu, Lei
;
Hong, Duidui
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  |  
浏览/下载:0/0
  |  
提交时间:2020/07/01
Proteasome inhibitors
Macrocyclic dipeptides
N-Benzyl amides
Metabolic stability
Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 164, 页码: 317-333
作者:
Shao, Jingwei
;
Zhu, Kongkai
;
Du, Daohai
;
Zhang, Yuanyuan
;
Tao, Hongrui
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  |  
浏览/下载:35/0
  |  
提交时间:2020/07/01
PRMT5 inhibitors
N-Substituted 1,2,3,4-tetrahydroisoquinoline derivatives
Anti-tumor
Two spiroketal derivatives with an unprecedented amino group and their cytotoxicity evaluation from the endophytic fungus Pestalotiopsis flavidula
期刊论文
FITOTERAPIA, 2019, 卷号: 135, 期号: x, 页码: 5-8
作者:
Rao, Li
;
You, Yun-Xia
;
Su, Yu
;
Liu, Yu
;
He, Qian
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  |  
浏览/下载:51/0
  |  
提交时间:2019/06/26
DIELS-ALDER REACTION
BIOACTIVE METABOLITES
FUNGICOLOUS ISOLATE
NATURAL-PRODUCTS
BIOSYNTHESIS
SESQUITERPENOIDS
MALDOXIN
SKELETON
Cytotoxic arylalkenyl alpha,beta-unsaturated delta-lactones from Cryptocarya brachythyrsa
期刊论文
FITOTERAPIA, 2019, 卷号: 136, 期号: x, 页码: -
作者:
Fan, Yue
;
Liu, Yu
;
You, Yun-Xia
;
Rao, Li
;
Su, Yu
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  |  
浏览/下载:70/0
  |  
提交时间:2019/07/23
STEREOSELECTIVE TOTAL-SYNTHESIS
INHIBITORY-ACTIVITY
ALPHA-PYRONE
FLAVONOIDS
LEAVES
CHINENSIS
ALKALOIDS
D1
Novel Resveratrol-chalcone Derivatives: Synthesis and Biological Evaluation
期刊论文
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2019, 卷号: 19, 期号: 5
作者:
Liu, Bei
;
Zhu, Ping
;
Zheng, Xi
;
Ma, Yulu
;
Wan, Chunping
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  |  
浏览/下载:34/0
  |  
提交时间:2019/12/04
Resveratrol
chalcon
anti-inflammatory activity
anti-proliferative activity
FACs analysis
inflammation
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