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浏览/检索结果: 共10条，第1-10条 帮助 限定条件 发表日期：2019    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery and Biological evaluation of pyrimido[4,5-d] pyrimidine-2,4(1H, 3H)-dione derivatives as potent Bruton's tyrosine kinase inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 15, 页码: 3390-3395 作者:  Diao, Yanyan;  Fang, Xiaoyu;  Song, Peiran;  Lai, Mengzhen;  Tong, Linjiang 收藏  |  浏览/下载：23/0  |  提交时间：2020/07/01 Bruton's tyrosine kinase  B-cell malignancies  Potent inhibitors  Structure-activity relationship  Cellular activities   SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC 期刊论文 AUTOPHAGY, 2019, 页码: 15 作者:  Zhang, Sulin;  Yang, Zhiwen;  Bao, Weilian;  Liu, Lixin;  You, Yan 收藏  |  浏览/下载：76/0  |  提交时间：2020/07/01 Colorectal cancer  macroautophagy  SNX10  SRC  tumor growth   Trained Macrophage Bioreactor for Penetrating Delivery of Fused Antitumor Protein 期刊论文 ACS APPLIED MATERIALS & INTERFACES, 2019, 卷号: 11, 期号: 26, 页码: 23018-23025 作者:  Zhang, Yu;  Zhang, Yujie;  Guo, Qin;  Guo, Zhongyuan;  Chen, Xinli 收藏  |  浏览/下载：36/0  |  提交时间：2020/07/01 macromolecular protein delivery  cell vector  tumor targeting  intratumoral drug distribution  breast cancer therapy   Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 11, 页码: 5414-5433 作者:  Guo, Zuhao;  Zhang, Zhuqing;  Yang, Hong;  Cao, Danyan;  Xu, Xiaowei 收藏  |  浏览/下载：18/0  |  提交时间：2020/07/01 Xanthatin inhibits STAT3 and NF-kappa B signalling by covalently binding to JAK and IKK kinases 期刊论文 JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2019, 卷号: 23, 期号: 6, 页码: 4301-4312 作者:  Liu, Man;  Xiao, Cheng-qian;  Sun, Ming-wei;  Tan, Min-jia;  Hu, Li-hong 收藏  |  浏览/下载：7/0  |  提交时间：2020/07/01 covalent interaction  IKK inhibitor  JAK inhibitor  natural compound   NPC1L1-Targeted Cholesterol-Grafted Poly(beta-Amino Ester)/pDNA Complexes for Oral Gene Delivery 期刊论文 ADVANCED HEALTHCARE MATERIALS, 2019, 卷号: 8, 期号: 8, 页码: 12 作者:  Liu, Yuan;  Chen, Dan;  Li, Jialin;  Xia, Dengning 收藏  |  浏览/下载：20/0  |  提交时间：2020/07/01 cellular uptake  cholesterol  oral gene delivery  transfection efficiency   Discovery of a potent tyrosine kinase AXL inhibitor bearing the 3-((2,3,4,5-tetrahydro-1H-benzo [d] azepin-7-yl)amino)pyrazine core 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 6, 页码: 836-838 作者:  Wang, Yueliang;  Xing, Li;  Ji, Yinchun;  Ye, Jiqing;  Dai, Yang 收藏  |  浏览/下载：16/0  |  提交时间：2020/07/01 AXL Kinase  Pyrazine  Cancer   Coxsackievirus A10 atomic structure facilitating the discovery of a broad-spectrum inhibitor against human enteroviruses 期刊论文 CELL DISCOVERY, 2019, 卷号: 5, 页码: 15 作者:  Chen, Jinhuan;  Ye, Xiaohua;  Zhang, Xue-Yang;  Zhu, Zhengdan;  Zhang, Xiang 收藏  |  浏览/下载：31/0  |  提交时间：2020/07/01 Synthesis and Biological Evaluation of Oxopyrido[2,3-d] Pyrimidine-7-ones Derivatives as Covalent L85812/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors 期刊论文 LETTERS IN DRUG DESIGN & DISCOVERY, 2019, 卷号: 16, 期号: 8, 页码: 826-834 作者:  Niu, Ao;  Wang, Yang;  Yang, Yushe;  Wei, Jianhai;  Ding, Jian 收藏  |  浏览/下载：12/0  |  提交时间：2020/07/01 Non-small cell lung cancer  irreversible inhibitors  EGFR(T79014)( )mutant  anti-tumor  xenograft model  cell proliferation   Allostery in Drug Development 期刊论文 PROTEIN ALLOSTERY IN DRUG DISCOVERY, 2019, 卷号: 1163, 页码: 1-23 作者:  Cheng, Xi;  Jiang, Hualiang 收藏  |  浏览/下载：14/0  |  提交时间：2020/07/01 Allosteric perturbation  Biased agonists  Conformational changes  Protein dynamics  Rational drug design