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科研机构
上海药物研究所 [3]
山东师范大学 [2]
西安交通大学 [1]
中南大学 [1]
武汉大学 [1]
复旦大学上海医学院 [1]
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内容类型
期刊论文 [12]
发表日期
2018 [12]
学科主题
Chemistry,... [1]
Pharmacolo... [1]
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Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer's Disease Agents
期刊论文
ACS chemical neuroscience, 2018
作者:
Xu, Yixiang
;
Zhang, Jian
;
Wang, Huan
;
Mao, Fei
;
Bao, Keting
收藏
  |  
浏览/下载:85/0
  |  
提交时间:2019/01/08
Ratiometric Near-Infrared Fluorescent Probe for Synergistic Detection of Monoamine Oxidase B and Its Contribution to Oxidative Stress in Cell and Mice Aging Models
期刊论文
ANALYTICAL CHEMISTRY, 2018, 卷号: 90, 期号: 6, 页码: 4054-4061
作者:
Wang, Rui
;
Han, Xiaoyue
;
You, Jinmao
;
Yu, Fabiao
;
Chen, Lingxin
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2018/09/19
Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 2, 页码: 328-345
作者:
Mao, Fei
;
Wang, Huan
;
Ni, Wei
;
Zheng, Xinyu
;
Wang, Manjiong
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2019/01/08
Alzheimer's disease
drug repositioning
dual-target inhibitor
AChE inhibition
PDE5 inhibition
Efficacy and safety of rasagiline in Chinese patients with early Parkinson's disease: a randomized, double-blind, parallel, placebo-controlled, fixed-dose study
期刊论文
TRANSLATIONAL NEURODEGENERATION, 2018, 卷号: 7
作者:
Zhang, Zhenxin
;
Wang, Jian
;
Chen, Shengdi
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/05
Parkinson's disease
Monoamine oxidase inhibitor
Rasagiline
Monotherapy
China
Coumarin-dithiocarbamate hybrids as novel multitarget AChE and MAO-B inhibitors against Alzheimer's disease: Design, synthesis and biological evaluation
期刊论文
BIOORGANIC CHEMISTRY, 2018, 卷号: 81
作者:
He, Qi
;
Liu, Jing
;
Lan, Jin-Shuai
;
Ding, Jiaoli
;
Sun, Yongbing
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/05
Coumarin
Dithiocarbamate
Cholinesterase
Monoamine oxidase
Alzheimer's disease
Repurposing psychiatric drugs as anti-cancer agents
期刊论文
Cancer Letters, 2018, 卷号: 419, 页码: 257-265
作者:
Huang, Jing
;
Zhao, Danwei
;
Liu, Zhixiong
;
Liu, Fangkun*
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/12/03
Antipsychotic drugs
Drug repurposing
Cancer treatment
Histone deacetylases
Phenothiazines
MSSA
methicillin-susceptible Staphylococus aureus
MRSA
methicillin-resistant
S. SSRIs
selective, serotonin reuptake inhibitors
MAOIs
monoamine oxidase inhibitors
HDACs
histone deacetylases
CSCs
cancer stem cells
DRs
dopamine receptors
Inhibition of transcription factor SP1 produces neuroprotective effects through decreasing MAO B activity in MPTP/MPP+ Parkinson's disease models
期刊论文
JOURNAL OF NEUROSCIENCE RESEARCH, 2018, 卷号: 96, 页码: 1663-1676
作者:
Yao, Lu
;
Dai, Xing
;
Sun, Yina
;
Wang, Yong
;
Yang, Qian
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/11/26
research resource identifiers
neuroprotection
Parkinson's disease
monoamine oxidase B
specificity protein 1
alpha-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson's disease
期刊论文
EMBO JOURNAL, 2018, 卷号: 37, 期号: 12
作者:
Kang, Seong Su
;
Ahn, Eun Hee
;
Zhang, Zhentao
;
Liu, Xia
;
Manfredsson, Fredric P.
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/05
delta-secretase (AEP)
DOPAL
MPTP
neurodegenerative diseases
Interacting Effect of Catechol-O-Methyltransferase (COMT) and Monoamine Oxidase A (MAOA) Gene Polymorphisms, and Stressful Life Events on Aggressive Behavior in Chinese Male AdolescentsSCI被引量:SCI原文链接
期刊论文
2018, 卷号: 9
作者:
Wang, Meiping[1]
;
Li, Hailei[2]
;
Deater-Deckard, Kirby[3]
;
Zhang, Wenxin[1]
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/31
Interacting Effect of Catechol-O-Methyltransferase (COMT) and Monoamine Oxidase A (MAOA) Gene Polymorphisms, and Stressful Life Events on Aggressive Behavior in Chinese Male Adolescents
期刊论文
2018, 卷号: 9, 页码: 1-9
作者:
Meiping Wang[1]
;
Hailei Li[2]
;
Kirby Deater-Deckard[3]
;
Wenxin Zhang[1]
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/31
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