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浏览/检索结果: 共54条，第1-10条 帮助 限定条件 发表日期：2018    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Natural flavonoid galangin alleviates microglia-trigged blood-retinal barrier dysfunction during the development of diabetic retinopathy 期刊论文 The Journal of nutritional biochemistry, 2018, 卷号: 65, 页码: 1-14 作者:  Zhang, Tianyu;  Mei, Xiyu;  Ouyang, Hao;  Lu, Bin;  Yu, Zengyang 收藏  |  浏览/下载：37/0  |  提交时间：2019/01/08 ETA as a novel Kv2.1 inhibitor ameliorates beta-cell dysfunction and hyperglycaemia 期刊论文 CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2018, 卷号: 45, 期号: 12, 页码: 1257-1264 作者:  Zhou, Tingting;  Du, Mengfan;  Zhao, Tong;  Quan, Lingling;  Zhu, Zhiyuan 收藏  |  浏览/下载：94/0  |  提交时间：2019/01/08 beta cell  apoptosis  glucose-stimulated insulin secretion  T2DM   Scutellarin alleviates blood-retina-barrier oxidative stress injury initiated by activated microglia cells during the development of diabetic retinopathy 期刊论文 Biochemical pharmacology, 2018, 卷号: 159, 页码: 82-95 作者:  Mei, Xiyu;  Zhang, Tianyu;  Ouyang, Hao;  Lu, Bin;  Wang, Zhengtao 收藏  |  浏览/下载：32/0  |  提交时间：2019/01/08 Molecular modelling studies on cinnoline-based BTK inhibitors using docking and structure-based 3D-QSAR 期刊论文 SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 2018, 卷号: 29, 期号: 11, 页码: 847-873 作者:  Li, R.;  Du, Y.;  Shen, J. 收藏  |  浏览/下载：36/0  |  提交时间：2019/01/08 BTK inhibitors  B-cell malignancies  molecule docking  3D-QSAR  CoMFA  CoMSIA   Identification of compound D2923 as a novel anti-tumor agent targeting CSF1R 期刊论文 ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 11, 页码: 1768-1776 作者:  Liu, Ying-Qiang;  Wang, Ya-Nan;  Lu, Xiao-Yun;  Tong, Lin-Jiang;  Li, Yan 收藏  |  浏览/下载：110/0  |  提交时间：2019/01/08 CSF-1R  small-molecule inhibitor  macrophage  myeloid leukemia   High-throughput screening campaigns against a PI3K alpha isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds 期刊论文 ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 11, 页码: 1816-1822 作者:  Wang, Jia;  Gong, Grace Qun;  Zhou, Yan;  Lee, Woo-Jeong;  Buchanan, Christina Maree 收藏  |  浏览/下载：84/0  |  提交时间：2019/01/08 high throughput screening  PI3 kinase  PI3K alpha H1047R  inhibitors  molecular modeling   Metabolism and disposition of pyrotinib in healthy male volunteers: covalent binding with human plasma protein 期刊论文 Acta pharmacologica Sinica, 2018 作者:  Meng, Jian;  Liu, Xiao-Yun;  Ma, Sheng;  Zhang, Hua;  Yu, Song-da 收藏  |  浏览/下载：98/0  |  提交时间：2019/01/08 Discovery of Potent Irreversible Pan-Fibroblast Growth Factor Receptor (FGFR) Inhibitors 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 20, 页码: 9085-9104 作者:  Wang, Yuming;  Li, Lijun;  Fan, Jun;  Dai, Yang;  Jiang, Alan 收藏  |  浏览/下载：29/0  |  提交时间：2019/01/08 Synthesis, biological evaluation and structure-activity relationship of a novel class of PI3K alpha H1047R mutant inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 707-719 作者:  Zhang, Ning;  Yu, Zhimei;  Yang, Xiaohong;  Zhou, Yan;  Wang, Jia 收藏  |  浏览/下载：85/0  |  提交时间：2019/01/08 Anticancer drug  Phosphatidylinositol 3-kinase  Structure-activity relationship   High-throughput screening for small molecule inhibitors of the type-I interferon signaling pathway 期刊论文 ACTA PHARMACEUTICA SINICA B, 2018, 卷号: 8, 期号: 6, 页码: 889-899 作者:  Yuliantie, Elita;  Dai, Xinchuan;  Yang, Dehua;  Crack, Peter J.;  Wang, Ming-Wei 收藏  |  浏览/下载：38/0  |  提交时间：2019/01/08 High-throughput screening  Interferon alpha receptor  Secreted embryonic alka-line phosphatase  JAK-STAT  IFN regulatory factor  Inhibitor