The use of cisplatin-loaded mucoadhesive nanofibers for local chemotherapy of cervical cancers in mice

	The use of cisplatin-loaded mucoadhesive nanofibers for local chemotherapy of cervical cancers in mice
	Zong, Shan 2; Wang, Xue 3; Yang, Yongping 2; Wu, Wenbin 4; Li, Hongjun 3; Ma, Yue 2; Lin, Wenhai 1; Sun, Tingting 1; Huang, Yubin 1; Xie, Zhigang 1
刊名	EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
	2015-06-01
卷号	93 页码:127-135
关键词	Cervical cancer Nanofibers Cisplatin Vaginal delivery Local chemotherapy
英文摘要	Polymer-based local drug delivery system may be suitable for the treatment of cervix cancer. A pilot study was carried out to examine the efficacy of cisplatin-loaded poly(ethylene oxide)/polylactide composite electrospun nanofibers as a local chemotherapy system against cervical cancer in mice via vaginal implantation. The nanofibers were proven to have good mucoadhesive property by in vitro mucoadhesion test and in vivo vaginal retention evaluation. An orthotopic cervical/vaginal cancer model was established by injecting murine cervical cancer U14 cells into the vaginal submucosa nearby the cervix. By inserting the nanofibers mat into the vagina of mice, the cisplatin released from the fiber-mat showed a much more accumulation in the vagina/cervix region than in the peripheral organs such as kidneys, liver, or blood, in contrary to the case of intravenous (i.v) injection. The in vivo trials showed that a better balance between anti-tumor efficacy and systemic safety was achieved in nanofibers group than that in i.v injection group at the equal drug dose. Therefore, electrospun nanofibers present a promising approach to the local drug delivery via vagina against cervical cancer. (C) 2015 Elsevier B.V. All rights reserved.
收录类别	SCI
语种	英语
公开日期	2015-11-02
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/27973]
专题	化学研究所_高分子物理与化学实验室
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Jilin Univ, Hosp 1, Changchun 130021, Peoples R China 3.Jilin Univ, China Japan Union Hosp, Changchun 130033, Peoples R China 4.Southeast Univ, Xuzhou Cent Hosp, Xuzhou 221009, Peoples R China
推荐引用方式 GB/T 7714	Zong, Shan,Wang, Xue,Yang, Yongping,et al. The use of cisplatin-loaded mucoadhesive nanofibers for local chemotherapy of cervical cancers in mice[J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,2015,93:127-135.
APA	Zong, Shan.,Wang, Xue.,Yang, Yongping.,Wu, Wenbin.,Li, Hongjun.,...&Jing, Xiabin.(2015).The use of cisplatin-loaded mucoadhesive nanofibers for local chemotherapy of cervical cancers in mice.EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,93,127-135.
MLA	Zong, Shan,et al."The use of cisplatin-loaded mucoadhesive nanofibers for local chemotherapy of cervical cancers in mice".EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 93(2015):127-135.