A novel synthesis of tetrahydrocortisone 3-glucuronide | |
Zhang, Y (Zhang, Yan) [1] , [2] , [3]; Zhang, SQ (Zhang, Suqing) [4]; Li, R (Li, Rui) [5]; Shen, JS (Shen, Jingshan) [3] , [4]; Jiang, XR (Jiang, Xiangrui) [3] , [4]; Aisa, HA (Aisa, Haji A.) [1] , [2] , [3] | |
刊名 | JOURNAL OF CARBOHYDRATE CHEMISTRY |
2022 | |
卷号 | 41期号:1页码:18-27 |
关键词 | Cortisone acetate Koenig-Knorr glycosylation lithium tri-tert-butoxyaluminum hydride tetrahydrocortisone 3-glucuronide |
ISSN号 | 0732-8303 |
DOI | 10.1080/07328303.2021.2023559 |
英文摘要 | A new route for the synthesis of tetrahydrocortisone 3-glucuronide has been developed with cortisone acetate as a starting material. The key step was using lithium tri-tert-butoxyaluminum hydride to reduce the C-3 carbonyl group of 5 beta-dihydrocortisone acetate (8) to provide 3 alpha-5 beta-tetrahydrocortisone acetate (5). Then, Koenig-Knorr method was used for glycosylation with glycosyl bromide as the donor, cadmium carbonate as promoter and 4 angstrom molecular sieves as dehydrating agent to give high yield of the desired product. The new route is shorter and gives higher yield than that reported in the literature. |
WOS记录号 | WOS:000740578900001 |
内容类型 | 期刊论文 |
源URL | [http://ir.xjipc.cas.cn/handle/365002/8177] |
专题 | 新疆理化技术研究所_资源化学研究室 |
通讯作者 | Aisa, HA (Aisa, Haji A.) [1] , [2] , [3] |
作者单位 | 1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Reg, Urumqi, Peoples R China 5.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Y ,Zhang, SQ ,Li, R ,et al. A novel synthesis of tetrahydrocortisone 3-glucuronide[J]. JOURNAL OF CARBOHYDRATE CHEMISTRY,2022,41(1):18-27. |
APA | Zhang, Y ,Zhang, SQ ,Li, R ,Shen, JS ,Jiang, XR ,&Aisa, HA .(2022).A novel synthesis of tetrahydrocortisone 3-glucuronide.JOURNAL OF CARBOHYDRATE CHEMISTRY,41(1),18-27. |
MLA | Zhang, Y ,et al."A novel synthesis of tetrahydrocortisone 3-glucuronide".JOURNAL OF CARBOHYDRATE CHEMISTRY 41.1(2022):18-27. |
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