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Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:
Wang, Z (Wang, Zhen)[ 1 ]
;
Jiang, XR (Jiang, Xiangrui)[ 1 ]
;
Zhang, XL (Zhang, Xianglei)[ 1,2 ]
;
Tian, GH (Tian, Guanghui)[ 3 ]
;
Yang, RL (Yang, Rulei)[ 3 ]
收藏
  |  
浏览/下载:133/0
  |  
提交时间:2019/06/28
Thermal Emitting Strategy to Synthesize Atomically Dispersed Pt Metal Sites from Bulk Pt Metal
期刊论文
Journal of the American Chemical Society, 2019, 卷号: 141, 页码: 4505-4509
作者:
Qu Yunteng[1]
;
Chen Bingxu[2]
;
Li Zhijun[3]
;
Duan Xuezhi[4]
;
Wang Liguang[5]
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浏览/下载:95/0
  |  
提交时间:2019/04/22
Flexible and wearable strain sensors based on tough and self-adhesive ion conducting hydrogels
期刊论文
JOURNAL OF MATERIALS CHEMISTRY B, 2019, 卷号: 7, 页码: 24-29
作者:
Wang, Zhenwu[1]
;
Chen, Jing[2]
;
Wang, Liufang[3]
;
Gao, Guorong[4]
;
Zhou, Yang[5]
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  |  
浏览/下载:22/0
  |  
提交时间:2019/04/22
Greatly Enhanced Faradic Capacities of 3D Porous Mn3O4/G Composites as Lithium-Ion Anodes and Supercapacitors by C-O-Mn Bonding
期刊论文
ACS APPLIED MATERIALS & INTERFACES, 2019, 卷号: 11, 页码: 10178-10188
作者:
Li, Shuang[1]
;
Yu, Li-Li[2]
;
Shi, Yu-Ting[3]
;
Fan, Jun[4]
;
Li, Rong-Bing[5]
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  |  
浏览/下载:24/0
  |  
提交时间:2019/04/22
lithium-ion battery
supercapacitor
C-O-Mn
manganese oxides
Faradic reaction
Hsp27 responds to and facilitates enterovirus A71 replication through enhancing viral IRES-mediated translation
期刊论文
Journal of virology, 2019
作者:
Dan Xuelian[1]
;
Wan Qianya[2]
;
Yi Lina[3]
;
Lu Jing[4]
;
Jiao Yang[5]
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  |  
浏览/下载:48/0
  |  
提交时间:2019/04/22
Integration of fluorescence imaging and electrochemical biosensing for both qualitative location and quantitative detection of cancer cells
期刊论文
BIOSENSORS & BIOELECTRONICS, 2019, 卷号: 130, 页码: 132-138
作者:
Cao, Ya[1]
;
Dai, Yuhao[2]
;
Chen, Hong[3]
;
Tang, Yingying[4]
;
Chen, Xu[5]
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  |  
浏览/下载:31/0
  |  
提交时间:2019/04/22
DNA-templated silver nanoclusters
Fluorescent imaging
Electrochemical detection
ITO electrode
MCF-7 cell
CircRNAFisher: a systematic computational approach for de novo circular RNA identification
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 页码: 55-63
作者:
Jia, Guo-yi[1]
;
Wang, Duo-lin[2]
;
Xue, Meng-zhu[3]
;
Liu, Yu-wei[4]
;
Pei, Yu-chen[5]
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  |  
浏览/下载:47/0
  |  
提交时间:2019/04/22
circRNA
RNA-Seq
alternative splicing
pipeline
Therapeutic effects of the total lignans from Vitex negundo seeds on collagen-induced arthritis in rats
期刊论文
Phytomedicine : international journal of phytotherapy and phytopharmacology, 2019, 卷号: 58, 页码: 152825
作者:
Jing Rui[1]
;
Ban Yanfei[2]
;
Xu Weiheng[3]
;
Nian Hua[4]
;
Guo Yaoli[5]
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  |  
浏览/下载:35/0
  |  
提交时间:2019/04/22
Anti-arthritic activity
Collagen-induced arthritis
Rheumatoid arthritis
Total lignans
Vitex negundo seeds
Human papillomavirus and p16 immunostaining, prevalence and prognosis of squamous carcinoma of unknown primary in the head and neck region
期刊论文
International journal of cancer, 2019
作者:
Ren Jianjun[1]
;
Yang Wen[2]
;
Su Jie[3]
;
Ren Xue[4]
;
Fazelzad Rouhi[5]
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/04/22
human papillomavirus
prevalence and prognosis
squamous carcinoma
unknown primary in the head and neck region
20(S)-protopanaxadiol induces apoptosis in human umbilical vein endothelial cells by activating the PERK-eIF2alpha-ATF4 signaling pathway
期刊论文
Journal of cellular biochemistry, 2019, 卷号: 120, 页码: 5085-5096
作者:
Wang Xue[1]
;
Xia Hua-Ying[2]
;
Qin Hong-You[3]
;
Kang Xiang-Ping[4]
;
Hu Hai-Yan[5]
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  |  
浏览/下载:41/0
  |  
提交时间:2019/04/22
ATF4
apoptosis
endoplasmic reticulum stress (ER stress)
human umbilical vein endothelial cells (HUVECs)
protein kinase R-like endoplasmic reticulum kinase (PERK)
protopanaxadiol (PPD)
small interfering RNA (siRNA)
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