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Design and Biophysical Characterization of Poly (L-Lactic) Acid Microcarriers with and without Modification of Chitosan and Nanohydroxyapatite 期刊论文
POLYMERS, 2018, 卷号: 10, 期号: 10, 页码: 17
作者:  Li, Liying;  Song, Kedong;  Chen, Yongzhi;  Wang, Yiwei;  Shi, Fangxin
收藏  |  浏览/下载：52/0  |  提交时间：2018/12/04
Design and Biophysical Characterization of Poly (L-Lactic) Acid Microcarriers with and without Modification of Chitosan and Nanohydroxyapatite 期刊论文
POLYMERS, 2018, 卷号: 10
作者:  Li, Liying;  Song, Kedong;  Chen, Yongzhi;  Wang, Yiwei;  Shi, Fangxin
收藏  |  浏览/下载：9/0  |  提交时间：2019/12/02
Development of Epigallocatechin-3-gallate-Encapsulated Nanohydroxyapatite/Mesoporous Silica for Therapeutic Management of Dentin Surface 期刊论文
ACS APPLIED MATERIALS & INTERFACES, 2017, 卷号: 9, 期号: 31
作者:  Huang, Cui
收藏  |  浏览/下载：14/0  |  提交时间：2019/12/05
Synthesis of europium-doped nanohydroxyapatite and its cytocompatibility with endothelial cells in vitro 期刊论文
MATERIALS TECHNOLOGY, 2016, 卷号: 31, 期号: [db:dc_citation_issue], 页码: 23-27
作者:  Ma, X.;  Liu, Y.;  Wu, X. M.;  Wang, C.;  Li, Q.
收藏  |  浏览/下载：6/0  |  提交时间：2019/12/02
Preparation and Characterization of Europium-Doped Nanohydroxyapatite (Eu-nHA) Fluorescent Agent 期刊论文
RARE METAL MATERIALS AND ENGINEERING, 2015, 卷号: 44, 期号: [db:dc_citation_issue], 页码: 32-35
作者:  Ma Xing;  Wu Xiaoming;  Qiu Yusheng
收藏  |  浏览/下载：1/0  |  提交时间：2019/12/02
Hydroxyapatite-doped polycaprolactone nanofiber membrane improves tendon-bone interface healing for anterior cruciate ligament reconstruction 期刊论文
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2015, 卷号: 10
作者:  Han, Fei;  Zhang, Peng;  Sun, Yaying;  Lin, Chao;  Zhao, Peng
收藏  |  浏览/下载：1/0  |  提交时间：2019/12/19
Supported nanohydroxyapatite on anodized titanium wire for solid-phase microextraction 期刊论文
Analytical and Bioanalytical Chemistry, 2014, 卷号: 406, 期号: 8, 页码: 2163-2170
作者:  Jia J(贾静);  Liu SJ(刘淑娟);  Qiu HD(邱洪灯);  Guo Y(郭勇);  Liu X(刘霞)
收藏  |  浏览/下载：22/0  |  提交时间：2014/10/17
Preparation and Physicochemical Properties of Hydroxyapatite/ Polyurethane Nanocomposites 期刊论文
高分子科学（英文版）, 2014, 卷号: No.4
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收藏  |  浏览/下载：1/0  |  提交时间：2019/03/26
Delivery system for DNAzymes using arginine-modified hydroxyapatite nanoparticles for therapeutic application in a nasopharyngeal carcinoma model 期刊论文
International Journal of Nanomedicine, 2013, 卷号: 8, 期号: 1, 页码: 3107-3118
作者:  Chen, Yan;  Yang, Lifang*;  Huang, Suping;  Li, Zhi;  Zhang, Lu
收藏  |  浏览/下载：8/0  |  提交时间：2019/12/03
DNAzymes are synthetic  single-stranded  catalytic nucleic acids that bind and cleave target mRNA in a sequence-specific manner  and have been explored for genotherapeutics. One bottleneck restricting their application is the lack of an efficient delivery system. As an inorganic nanomaterial with potentially wide application  nanohydroxyapatite particles (nHAP) have attracted increasing attention as new candidates for nonviral vectors. In this study  we developed an nHAP-based delivery system and explored its cellular uptake mechanisms  intracellular localization  and biological effects. Absorption of arginine-modified nanohydroxyapatite particles (Arg-nHAP) and DZ1 (latent membrane protein 1 [LMP1]-targeted) reached nearly 100% efficiency under in vitro conditions. Using specific inhibitors  cellular uptake of the Arg-nHAP/DZ1 complex was shown to be mediated by the energy-dependent endocytosis pathway. Further  effective intracellular delivery and nuclear localization of the complex was confirmed by confocal microscopy. Biologically  the complex successfully downregulated the expression of LMP1 in nasopharyngeal carcinoma cells. In a mouse tumor xenograft model  the complex was shown to be delivered efficiently to tumor tissue  downregulating expression of LMP1 and suppressing tumor growth. These results suggest that Arg-nHAP may be an efficient vector for nucleic acid-based drugs with potential clinical application.  
Preparation and Properties of Biodegradable Composites Derived from Poly(lactide-co-glycolide), Poly(L-lactide), and Nanohydroxyapatite 期刊论文
JOURNAL OF MACROMOLECULAR SCIENCE PART B-PHYSICS, 2013, 卷号: 52, 期号: 3, 页码: 462-475
作者:  Chen, X;  Zhang, LW;  Liu, X;  Cui, YJ;  Zhao, GH
收藏  |  浏览/下载：3/0  |  提交时间：2016/03/29

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