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科研机构
大连理工大学 [1]
兰州大学 [1]
上海药物研究所 [1]
武汉物理与数学研究所 [1]
山东大学 [1]
中南大学 [1]
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期刊论文 [7]
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2019 [2]
2018 [2]
2017 [2]
2011 [1]
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automation... [1]
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Discovery of Novel Androgen Receptor Ligands by Structure-based Virtual Screening and Bioassays
期刊论文
GENOMICS PROTEOMICS & BIOINFORMATICS, 2019, 卷号: 16, 期号: 6, 页码: 416-427
作者:
Hou, Tingjun
;
Li, Dan
;
Chang, Shan
;
Xu, Lei
;
Sun, Huiyong
收藏
  |  
浏览/下载:259/0
  |  
提交时间:2019/06/24
Androgen receptor
AR ligand
Virtual screening
AR agonist
AR antagonist
Targeting Purinergic Receptor P2Y2 Prevents the Growth of Pancreatic Ductal Adenocarcinoma by Inhibiting Cancer Cell Glycolysis
期刊论文
CLINICAL CANCER RESEARCH, 2019, 卷号: 25, 页码: 1318-1330
作者:
Hu, Li-Peng
;
Zhang, Xiao-Xin
;
Jiang, Shu-Heng
;
Tao, Ling-Ye
;
Li, Qing
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/12/02
adenosine triphosphate
ar c118925xx
gemcitabine
glucose transporter 1
hypoxia inducible factor 1alpha
Myc protein
platelet derived growth factor beta receptor
platelet derived growth factor receptor
protein kinase Yes
purinergic P2Y receptor antagonist
purinergic P2Y2 receptor
unclassified drug
Yes1 protein, Akt signaling
animal experiment
animal model
animal tissue
Article
cancer inhibition
cancer prognosis
cancer staging
controlled study
drug potentiation
glycolysis
human
human cell
human tissue
inflammation
lymph node metastasis
male
mouse
mouse model
nonhuman
overall survival
pancreas adenocarcinoma
pancreatic ductal carcinoma cell line
Pi3K/Akt signaling
priority journal
RNA sequence
tumor classification
tumor differentiation
tumor microenvironment
tumor volume
tumor xenograft
Broad targeting of triptolide to resistance and sensitization for cancer therapy
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:
Hou, Zhen-yan
;
Tong, Xiao-pei
;
Peng, Yong-bo
;
Zhang, Bi-Kui*
;
Yan, Miao*
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2019/12/03
ABC
ATP-binding cassette
AKT
V-Akt murine thymoma viral oncogene homolog
ALDH1
aldehyde dehydrogenase 1
AR
androgen receptor
Bad
Bcl-2-associated death promoter
Bak
Bcl-2 homologous antagonist killer
Bax
Bcl-2-associated X protein
Bcl-2
B-cell lymphoma
Bcl-xL
Bcl-extra large
Bcl-xs
Bcl-extra short
BCRP
breast cancer resistance protein
Bid
BH3 interacting domain death agonist
Bik
Bcl-2-interacting killer
BNIP3
Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3
CAF
cancer-associated fibroblast
CAIX
carbonic anhydrase IX
cFLIP
cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein
ChIP
chromatin immunoprecipitation
CI
Combination Index
cIAP1/2
cellular IAP1/2
CML
chronic myelogenous leukemia
CSC
cancer stem cell
DISC
death-inducing signaling complex
DR
death receptor
DRI
Dose Reduction Index
ECM
extracellular matrix
EMT
epithelial-mesenchymal transition
EpCAM
epithelial cell adhesion molecule
GLUT
glucose transporter
GSK3β
glycogen synthase kinase-3β
HIF-1
hypoxia inducible factor-1
HSF1
heat shock factor 1
HSP
heat shock protein
IAP
inhibitor of apoptosis protein
JNK
c-JUN N-terminal kinase
MAPK
mitogen-activated protein kinase
Mcl-1
myeloid leukemia cell differentiation protein
MDM2
murine double minute 2
MDR
multidrug resistance
MKP
MAPK phosphatase
MRP1
multidrug resistance protein 1
NF-κB
nuclear factor-kappaB
pAkt
phosphor-Akt
PARP
poly ADP-ribose polymerase
P-gp
P-glycoprotein
PI3K-PTEN
phosphatidylinositol 3-kinase-phosphatase and tensin homolog
PKC
phosphorylated at Ser9 by protein kinase C
pp2A
protein phosphatase 2A
REST
repressor element-1 silencing transcription factor
SAR
structure-activity relationship
TAM
tumor-associated macrophage
TFIIH
transcription factor IIH
TKI
tyrosine kinase inhibitor
TM
tumor-microenvironment
TRAIL/Apo-2L
TNF-related apoptosis-inducing ligand
tRXRα
the N-terminal truncated form of the nuclear retinoid X receptor-α
TWHF
Tripterygium wilfordii Hook F
VEGF
vascular endothelial growth factor
XIAP
X-linked IAP
XPB
xerodermapigmentosum group B protein
Triptolide
Antineoplastic
Resistance
Sensitization
Mechanism
Discovery of novel 5-methyl-1H-pyrazole derivatives as potential antiprostate cancer agents: Design, synthesis, molecular modeling, and biological evaluation
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2018, 卷号: 91, 期号: 6, 页码: 1113-1124
作者:
Zhang, Daoguang
;
Asnake, Solomon
;
Zhang, Jingya
;
Olsson, Per-Erik
;
Zhao, Guisen
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/11
androgen receptor
AR antagonist
luciferase reporter gene assay
prostate cancer
pyrazole derivative
Platelets Express Activated P2Y(12) Receptor in Patients With Diabetes Mellitus
期刊论文
CIRCULATION, 2017, 卷号: 136, 期号: 9, 页码: 817-U102
作者:
Hu, Liang
;
Chang, Lin
;
Zhang, Yan
;
Zhai, Lili
;
Zhang, Shenghui
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
antiplatelet
antithrombotic
AR-C78511
cangrelor
inverse agonist
P2Y(12)
P2Y(12) receptor antagonist
type 2 diabetes mellitus
Platelets Express Activated P2Y(12) Receptor in Patients With Diabetes Mellitus
期刊论文
CIRCULATION, 2017, 卷号: 136, 期号: 9
作者:
Hu, Liang
;
Chang, Lin
;
Zhang, Yan
;
Zhai, Lili
;
Zhang, Shenghui
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
antiplatelet
antithrombotic
AR-C78511
cangrelor
inverse agonist
P2Y(12)
P2Y(12) receptor antagonist
type 2 diabetes mellitus
Quantitative structure-activity relationship analysis of a novel series of chemicals antagonizing WT and MT AR
期刊论文
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 2011, 卷号: 107, 期号: 2, 页码: 283-289
作者:
Huo, X
;
Li, JZ
;
Gramatica, P
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2015/12/29
Prostate cancer
Drug resistance
WT AR
MT AR
Antagonist
QSAR
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