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科研机构
上海药物研究所 [22]
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期刊论文 [22]
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2022 [1]
2020 [4]
2018 [2]
2017 [3]
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New Cembrane-Type Diterpenoids from the South China Sea Soft Coral Sinularia nanolobata
期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2022, 卷号: 40, 期号: 1, 页码: 28-38
作者:
Lin, Na
;
Li, Heng
;
Wang, Jian-Rong
;
Tang, Wei
;
Zheng, Ming-Yue
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/01/04
Sinularia nanolobata
Cembranoids
X-ray diffraction
Configuration determination
Natural products
Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 293-302
作者:
Wang, Jin-tao
;
Zheng, Yue-ming
;
Chen, Yue-ting
;
Gu, Min
;
Gao, Zhao-bing
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2020/07/01
Nav1
7 sodium channel
aryl sulfonamide
maprotiline
compound 10o
electrophysiology
acetic acid-induced visceral pain
analgesic activity
Discovery and characterization of natural products as novel indoleamine 2,3-dioxygenase 1 inhibitors through high-throughput screening
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 423-431
作者:
Guo, Wei
;
Yao, Sheng
;
Sun, Pu
;
Yang, Tian-biao
;
Tang, Chun-ping
收藏
  |  
浏览/下载:79/0
  |  
提交时间:2020/07/01
indoleamine 2
3-dioxygenase 1 inhibitor
natural product library
high-throughput fluorescence-based screening
Quantitative Proteomics Reveals the Protective Effects of Huangqi Decoction Against Acute Cholestatic Liver Injury by Inhibiting the NF-kappa B/IL-6/STAT3 Signaling Pathway
期刊论文
JOURNAL OF PROTEOME RESEARCH, 2020, 卷号: 19, 期号: 2, 页码: 677-687
作者:
Wu, Jia-Sheng
;
Liu, Qian
;
Fang, Shan-Hua
;
Liu, Xing
;
Zheng, Min
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/01
intrahepatic cholestasis
Huangqi decoction
proteomics
NF-kappa B
IL-6
STAT3
Antiepileptic geissoschizine methyl ether is an inhibitor of multiple neuronal channels
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Xie, Zhu-qing
;
Tian, Xiao-ting
;
Zheng, Yue-ming
;
Zhan, Li
;
Chen, Xue-qin
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
geissoschizine methyl ether
Uncaria rhynchophyll
antiepileptic drug
hippocampal neurons
action potential
nicotinic acetylcholine receptors
voltage-gated ion channels
mouse seizure model
Inhibitory effects of lappaconitine on the neuronal isoforms of voltage-gated sodium channels
期刊论文
Acta pharmacologica Sinica, 2018
作者:
Li, Yan-Fen
;
Zheng, Yue-Ming
;
Yu, Yong
;
Gan, Yong
;
Gao, Zhao-Bing
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
Enhancing inactivation rather than reducing activation of Nav1.7 channels by a clinically effective analgesic CNV1014802
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 4, 页码: 587-596
作者:
Zheng, Yue-ming
;
Wang, Wan-fu
;
Li, Yan-fen
;
Yu, Yong
;
Gao, Zhao-bing
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2019/01/08
Nav1.7 channels
analgesics
CNV1014802
inactivated state
paroxysmal extreme pain disorder
Conformation and dynamics of the C-terminal region in human phosphoglycerate mutase 1
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 12, 页码: 1673-1682
作者:
Liu, Shi-en
;
Hu, Jun-chi
;
Zhang, Hao
;
Xu, Pan
;
Wan, Wei
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
phosphoglycerate mutase 1 (PGAM1)
human cancers
metabolic target
C-terminal region
conformational changes
molecular dynamics simulation
Chicken bile powder protects against α-naphthylisothiocyanate-induced cholestatic liver injury in mice
期刊论文
Oncotarget, 2017, 卷号: 8, 期号: 57, 页码: 97137-97152
作者:
Li, Yi-Fei
;
Wu, Jia-Sheng
;
Li, Yuan-Yuan
;
Dai, Yan
;
Zheng, Min
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/01/08
In Silico Prediction of Chemical Toxicity Profile Using Local Lazy Learning
期刊论文
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 2017, 卷号: 20, 期号: 4, 页码: 346-353
作者:
Lu, Jing
;
Zhang, Pin
;
Zou, Xiao-Wen
;
Zhao, Xiao-Qiang
;
Cheng, Ke-Guang
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
Toxicity profile
Local lazy learning
ECFP_4
Laplacian-modified Bayesian
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