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Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer 期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 卷号: 110, 页码: 51-61
作者:  Li, Xin;  Yang, Changyong;  Wan, Hong;  Zhang, Ge;  Feng, Jun
收藏  |  浏览/下载：136/0  |  提交时间：2019/01/08
Mutation L1196M-induced conformational changes and the drug resistant mechanism of anaplastic lymphoma kinase studied by free energy perturbation and umbrella sampling 期刊论文
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2017, 卷号: 19, 期号: 44, 页码: 30239-30248
作者:  Chen, Jianzhong;  Wang, Jinan;  Zhu, Weiliang
收藏  |  浏览/下载：17/0  |  提交时间：2019/01/08
Dihydroartemisinin selectively inhibits PDGFR alpha-positive ovarian cancer growth and metastasis through inducing degradation of PDGFR alpha protein 期刊论文
CELL DISCOVERY, 2017, 卷号: 3
作者:  Li, Xiaoguang;  Ba, Qian;  Liu, Yanling;  Yue, Qingxi;  Chen, Peizhan
收藏  |  浏览/下载：43/0  |  提交时间：2019/01/08
Design, Synthesis, and Evaluation of Ribose-Modified Anilinopyrimidine Derivatives as EGFR Tyrosine Kinase Inhibitors 期刊论文
FRONTIERS IN CHEMISTRY, 2017, 卷号: 5
作者:  Hu, Xiuqin;  Wang, Disha;  Tong, Yi;  Tong, Linjiang;  Wang, Xia
收藏  |  浏览/下载：60/0  |  提交时间：2019/01/08
Structure-based design and synthesis of 2,4-diaminopyrimidines as EGFR L858R/T790M selective inhibitors for NSCLC 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 140, 页码: 510-527
作者:  Chen, Lingfeng;  Fu, Weitao;  Feng, Chen;  Qu, Rong;  Tong, Linjiang
收藏  |  浏览/下载：55/0  |  提交时间：2019/01/08
A Novel Vascular Endothelial Growth Factor Receptor Participates in White Spot Syndrome Virus Infection in Litopenaeus vannamei 期刊论文
FRONTIERS IN IMMUNOLOGY, 2017, 卷号: 8
作者:  Li, Shihao;  Wang, Zhiwei;  Li, Fuhua;  Yu, Kuijie;  Xiang, Jianhai
收藏  |  浏览/下载：29/0  |  提交时间：2018/01/11
Facile Synthesis of Novel Perfluorocarbon-Modulated 4-Anilinoquinazoline Analogues 期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2017, 卷号: 35, 期号: 11, 页码: 1693-1700
作者:  Shi, Huiping;  Lai, Bonan;  Chen, Shizhen;  Zhou, Xin;  Nie, Jing
收藏  |  浏览/下载：64/0  |  提交时间：2018/11/05
Optimization of 1H-indazol-3-amine derivatives as potent fibroblast growth factor receptor inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 16, 页码: 3782-3786
作者:  Cui, Jing;  Peng, Xia;  Gao, Dingding;  Dai, Yang;  Ai, Jing
收藏  |  浏览/下载：16/0  |  提交时间：2019/01/08
Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 14, 页码: 6018-6035
作者:  Zhu, Wei;  Chen, Hui;  Wang, Yulan;  Wang, Jiang;  Peng, Xia
收藏  |  浏览/下载：18/0  |  提交时间：2019/01/08
Structure-Guided Design of C4-alkyl-1,4-dihydro-2H-pyrimido[4,5-d][1,3]oxazin-2-ones as Potent and Mutant-Selective Epidermal Growth Factor Receptor (EGFR) L858R/T790M Inhibitors 期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7
作者:  Hao, Yongjia;  Lyu, Jiankun;  Qu, Rong;  Sun, Deheng;  Zhao, Zhenjiang
收藏  |  浏览/下载：32/0  |  提交时间：2019/01/08

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