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3-Deoxy-2 beta,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells 期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 12, 页码: 1578-1586
作者:  Shan, Hui;  Yao, Sheng;  Ye, Yang;  Yu, Qiang
收藏  |  浏览/下载:9/0  |  提交时间:2020/07/01
Simultaneous determination of alflutinib and its active metabolite in human plasma using liquid chromatography-tandem mass spectrometry 期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 176, 页码: 6
作者:  Liu, Xiaoyun;  Li, Wei;  Zhang, Yifan;  Jian, Yong;  Zhao, Qianyu
收藏  |  浏览/下载:14/0  |  提交时间:2020/07/01
Tyrosine Kinase 2 (TYK2) Allosteric Inhibitors To Treat Autoimmune Diseases 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 20, 页码: 8951-8952
作者:  Chang, Yu;  Xu, Shilin;  Ding, Ke
收藏  |  浏览/下载:16/0  |  提交时间:2020/07/01
SHR-A1403, a novel c-mesenchymal-epithelial transition factor (c-Met) antibody-drug conjugate, overcomes AZD9291 resistance in non-small cell lung cancer cells overexpressing c-Met 期刊论文
CANCER SCIENCE, 2019, 页码: 11
作者:  Tong, Mengya;  Gao, Mingzhao;  Xu, Yongping;  Fu, Li;  Li, Yun
收藏  |  浏览/下载:21/0  |  提交时间:2020/07/01
Safety, Efficacy, and Biomarker Analysis of Pyrotinib in Combination with Capecitabine in HER2-Positive Metastatic Breast Cancer Patients: A Phase I Clinical Trial 期刊论文
CLINICAL CANCER RESEARCH, 2019, 卷号: 25, 期号: 17, 页码: 5212-5220
作者:  Li, Qiao;  Guan, Xiuwen;  Chen, Shanshan;  Yi, Zongbi;  Lan, Bo
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/01
Transforming growth factor beta signaling pathway: A promising therapeutic target for cancer 期刊论文
JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 页码: 12
作者:  Yang, Hongying;  Zhang, Hong;  Zhang, Qianjing;  Zhang, Jinhua;  Xu, Caipeng
收藏  |  浏览/下载:59/0  |  提交时间:2019/11/10
SHR-A1403, a novel c-Met antibody-drug conjugate, exerts encouraging anti-tumor activity in c-Met-overexpressing models 期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 7, 页码: 971-979
作者:  Yang, Chang-yong;  Wang, Lei;  Sun, Xing;  Tang, Mi;  Quan, Hai-tian
收藏  |  浏览/下载:14/0  |  提交时间:2020/07/01
Discovery and characterization of a novel highly potent and selective type II native and drug-resistant V299L mutant BCR-ABL inhibitor (CHMFL-ABL-039) for Chronic Myeloid Leukemia (CML) 期刊论文
CANCER BIOLOGY & THERAPY, 2019, 卷号: 20, 期号: 6, 页码: 877-885
作者:  Wu, Jiaxin;  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Qi, Ziping
收藏  |  浏览/下载:29/0  |  提交时间:2019/11/27
Design, synthesis and biological study of potent and covalent HER-2 tyrosine kinase inhibitors with low cytotoxicity in vitro 期刊论文
CHEMICAL PAPERS, 2019, 卷号: 73, 期号: 6, 页码: 1333-1345
作者:  Jin, Shuyu;  Sun, Xiuyun;  Liu, Dan;  Xie, Hua;  Rao, Yu
收藏  |  浏览/下载:7/0  |  提交时间:2020/07/01
Development and validation of a prognostic index for efficacy evaluation and prognosis of first-line chemotherapy in stage III-IV lung squamous cell carcinoma 期刊论文
EUROPEAN RADIOLOGY, 2019, 卷号: 29, 期号: 5, 页码: 2388-2398
作者:  Song, Jiangdian;  Tian, Jie;  Zhang, Lina;  Qu, Xiujuan;  Qian, Wei
收藏  |  浏览/下载:64/0  |  提交时间:2019/07/12


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