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科研机构
上海药物研究所 [61]
内容类型
期刊论文 [61]
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2020 [4]
2019 [3]
2018 [6]
2017 [2]
2016 [5]
2015 [4]
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Endocrinol... [2]
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Pyrazolone derivative C29 protects against HFD-induced obesity in mice via activation of AMPK in adipose tissue
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11
作者:
Li, Bo-han
;
Zhang, Mei
;
Duan, Ya-nan
;
Shuai, Lin
;
Jiang, Hao-wen
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2020/12/21
AMP-activated protein kinase
pyrazolone derivative C29
obesity
energy expenditure
thermogenesis
inguinal white adipose tissue
white adipose browning
Low-protein/high-carbohydrate diet induces AMPK-dependent canonical and non-canonical thermogenesis in subcutaneous adipose tissue
期刊论文
REDOX BIOLOGY, 2020, 卷号: 36, 页码: 14
作者:
Aquilano, Katia
;
Sciarretta, Francesca
;
Turchi, Riccardo
;
Li, Bo-Han
;
Rosina, Marco
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2020/12/21
Systems physiology
Mitochondria
Metabolism
Serca
Ucp1
Loss of hnRNP A1 in murine skeletal muscle exacerbates high-fat diet-induced onset of insulin resistance and hepatic steatosis
期刊论文
JOURNAL OF MOLECULAR CELL BIOLOGY, 2020, 卷号: 12, 期号: 4, 页码: 277-290
作者:
Zhao, Mingxia
;
Shen, Lihong
;
Ouyang, Zijun
;
Li, Manru
;
Deng, Guoliang
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/12/24
hnRNP A1
insulin resistance
hepatic steatosis
glycogen synthesis
Establishment of a mouse model of cancer cachexia with spleen deficiency syndrome and the effects of atractylenolide I
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 2, 页码: 237-248
作者:
Zhang, Wan-li
;
Li, Na
;
Shen, Qiang
;
Fan, Men
;
Guo, Xiao-dong
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2020/07/01
cancer cachexia
traditional Chinese medicine
spleen deficiency
animal model
muscle atrophy
fat lipolysis
atractylenolide I
metabolic syndrome
Natural constituents from food sources: potential therapeutic agents against muscle wasting
期刊论文
FOOD & FUNCTION, 2019, 卷号: 10, 期号: 11, 页码: 6967-6986
作者:
Shen, Shengnan
;
Yu, Hua
;
Gan, Lishe
;
Ye, Yang
;
Lin, Ligen
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
TGR5 agonist ameliorates insulin resistance in skeletal muscles and improves glucose homeostasis in diabetic mice
期刊论文
METABOLISM-CLINICAL AND EXPERIMENTAL, 2019, 卷号: 99, 页码: 45-56
作者:
Huang, Suling
;
Ma, Shanyao
;
Ning, Mengmeng
;
Yang, Wenji
;
Ye, Yangliang
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
TGR5
Glucose homeostasis
Insulin resistance
Skeletal muscle
Type 2 diabetes
Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 卷号: 294, 期号: 3, 页码: 953-967
作者:
Yan, Yan
;
Zhou, X. Edward
;
Novick, Scott J.
;
Shaw, Simon J.
;
Li, Yingwu
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/07/01
AMP-activated kinase (AMPK)
AMP
hydrogen exchange mass spectrometry
X-ray crystallography
phosphorylation
activation loop phosphorylation
ADaM site
CBS3
R734
R739
metabolic disorder
energy sensor
Conformational heterogeneity of the allosteric drug and metabolite (ADaM) site in AMP-activated protein kinase (AMPK)
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 44, 页码: 16994-17007
作者:
Gu, Xin
;
Bridges, Michael D.
;
Yan, Yan
;
de Waal, Parker W.
;
Zhou, X. Edward
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2019/01/08
AMP-activated kinase (AMPK)
biophysics
diabetes
metabolic regulation
cancer
ADaM site
DEER
Novel substituted pyrazolone derivatives as AMP-activated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 10, 页码: 1622-1632
作者:
Zhang, Mei
;
Xie, Zhi-fu
;
Zhang, Run-tao
;
Chen, Da-kai
;
Gu, Min
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/01/08
non-alcoholic fatty liver disease
AMP-activated protein kinase
AMPK activator
homogeneous time-resolved fluorescence
metabolic disorders
ob/ob mice
A preclinical overview of metformin for the treatment of type 2 diabetes
期刊论文
BIOMEDICINE & PHARMACOTHERAPY, 2018, 卷号: 106, 页码: 1227-1235
作者:
Zhou, Tingting
;
Xu, Xin
;
Du, Mengfan
;
Zhao, Tong
;
Wang, Jiaying
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2019/01/08
Gluconeogenesis
Insulin sensitivity
Mechanism
Metformin
Type 2 diabetes (T2D)
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