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浏览/检索结果: 共8条，第1-8条 帮助 限定条件 发表日期：2018     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3693-3699 作者:  Zhu, Kongkai;  Song, Jia-Li;  Tao, Hong-Rui;  Cheng, Zhi-Qiang;  Jiang, Cheng-Shi 收藏  |  浏览/下载：100/0  |  提交时间：2019/01/08 Pharmacophore combination  Isoquinoline  PRMT5 inhibitor  Molecular docking  Molecular dynamics simulation   Identification of a novel selective small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) by virtual screening, resynthesis and biological evaluations 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 9, 页码: 1476-1483 作者:  Zhu, Kongkai;  Jiang, Chengshi;  Tao, Hongrui;  Liu, Jingqiu;  Zhang, Hua 收藏  |  浏览/下载：59/0  |  提交时间：2019/01/08 PRMT5 inhibitor  Resynthesis  Virtual screening  Molecular docking  Molecular dynamics simulation   Computer-Aided Drug Design in Epigenetics 期刊论文 FRONTIERS IN CHEMISTRY, 2018, 卷号: 6 作者:  Lu, Wenchao;  Zhang, Rukang;  Jiang, Hao;  Zhang, Huimin;  Luo, Cheng 收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08 drug discovery  epigenetics  small-molecule inhibitor  computer-aided drug design  virtual screening   Prognostic impact of SET domain-containing protein 8 and protein arginine methyltransferase 5 in patients with hepatocellular carcinoma following curative resection 期刊论文 ONCOLOGY LETTERS, 2018, 卷号: 16, 期号: 3 作者:  Lin, Zhifei;  Jia, Huliang;  Hong, Liang;  Zheng, Yahui;  Shao, Weiqin 收藏  |  浏览/下载：6/0  |  提交时间：2019/12/05 SET domain-containing protein 8  protein arginine methyltransferase 5  hepatocellular carcinoma  recurrence  prognosis   Protein arginine methyltransferase 1 coordinates the epithelial-mesenchymal transition/proliferation dichotomy in gastric cancer cells 期刊论文 EXPERIMENTAL CELL RESEARCH, 2018, 卷号: 362, 期号: 1, 页码: 43-50 作者:  Zhang, Youli[1];  Wang, Dawei[2];  Zhang, Meiting[3];  Wei, Hong[4];  Lu, Ying[5] 收藏  |  浏览/下载：14/0  |  提交时间：2019/12/24 PRMT1  EMT  Migration-proliferation dichotomy  Gastric cancer  Hippo pathway   Protein arginine N-methyltransferase 2 reverses tamoxifen resistance in breast cancer cells through suppression of ER-alpha36. 期刊论文 Oncology Reports, 2018, 卷号: 39, 期号: 6, 页码: 2604-2612 作者:  Shen, Yingying 收藏  |  浏览/下载：5/0  |  提交时间：2019/12/27 protein arginine N-methyltransferase 2  PRMT2  ER-alpha 36  breast cancer  tamoxifen  resistance   Interaction assessments of the first S-adenosylmethionine competitive inhibitor and the essential interacting partner methylosome protein 50 with protein arginine methyltransferase 5 by combined computational methods 期刊论文 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 卷号: 495, 期号: 1, 页码: 721-727 作者:  Zhu, Kongkai;  Jiang, Cheng-Shi;  Hu, Junchi;  Liu, Xigong;  Yan, Xue 收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08 PRMT5 SAM competitive inhibitor  Molecular docking  Molecular dynamics simulation  Molecular mechanics/Poisson-Boltzmann surface area  PRMT5:MEP50 interaction   Systematic Proteomic Analysis of Protein Methylation in Prokaryotes and Eukaryotes Revealed Distinct Substrate Specificity 期刊论文 PROTEOMICS, 2018, 卷号: 18, 期号: 1 作者:  Zhang, Min;  Xu, Jun-Yu;  Hu, Hao;  Ye, Bang-Ce;  Tan, Minjia 收藏  |  浏览/下载：20/0  |  提交时间：2019/01/08 heavy methyl silac  histone  mass spectrometry  methylation  proteomics