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科研机构
上海药物研究所 [48]
内容类型
期刊论文 [48]
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2021 [4]
2020 [5]
2019 [7]
2018 [5]
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SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade
期刊论文
EMBO JOURNAL, 2021, 页码: 16
作者:
Wang, Xu
;
Ni, Jiahui
;
You, Yan
;
Feng, Guize
;
Zhang, Sulin
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/12/16
E-cadherin
IBD
intestinal barrier function
LPS release
SNX10
Catalytic System-Controlled Divergent Reaction Strategies for the Construction of Diversified Spiropyrazolone Skeletons from Pyrazolidinones and Diazopyrazolones
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 8
作者:
Fang, Feifei
;
Hu, Shulei
;
Li, Chunpu
;
Wang, Qian
;
Wang, Run
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/11/04
[n+1] annulation
C(sp(3))-H bond activation
N-N bond activation
pyrazolidinones
spiropyrazolones
A Rh(iii)-catalyzed C-H activation/regiospecific annulation cascade of benzoic acids with propargyl acetates to unusual 3-alkylidene-isochromanones
期刊论文
ORGANIC CHEMISTRY FRONTIERS, 2021, 页码: 7
作者:
Li, Jiyuan
;
Fang, Feifei
;
Wang, Run
;
Li, Yuan
;
Xu, Bin
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2021/08/17
Rhodium-Catalyzed C-H Activation/Annulation Cascade of Aryl Oximes and Propargyl Alcohols to Isoquinoline N-Oxides
期刊论文
ADVANCED SYNTHESIS & CATALYSIS, 2021, 页码: 7
作者:
Li, Yuan
;
Fang, Feifei
;
Zhou, Jianhui
;
Li, Jiyuan
;
Wang, Run
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2021/08/17
Isoquinoline N-oxides
beta-hydroxy elimination
Rhodium
Secondary propargyl alcohols
A removable directing group-assisted Rh(iii)-catalyzed direct C-H bond activation/annulation cascade to synthesize highly fused isoquinolines
期刊论文
ORGANIC CHEMISTRY FRONTIERS, 2020, 卷号: 7, 期号: 20, 页码: 3186-3192
作者:
Cheng, Yilang
;
Han, Xu
;
Li, Junyou
;
Zhou, Yu
;
Liu, Hong
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/12/24
AMPK activator C24 inhibits hepatic lipogenesis and ameliorates dyslipidemia in HFHC diet-induced animal models
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 8
作者:
Sun, Shui-mei
;
Xie, Zhi-fu
;
Zhang, Yang-ming
;
Zhang, Xin-wen
;
Zhou, Chen-dong
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/12/24
adenosine 5 '-monophosphate-activated protein kinase
AMPK activator
C24
liver
triglycerides
cholesterol
VLDL
hypolipidemic drug
metabolic syndrome
Cancer nanomedicine meets immunotherapy: opportunities and challenges
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 7, 页码: 954-958
作者:
Sun, Qingxue
;
Bai, Xiangyang
;
Sofias, Alexandros Marios
;
van der Meel, Roy
;
Ruiz-Hernandez, Eduardo
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/12/24
nanomedicine
immunotherapy
targeting
combination therapy
clinical translation
Complex Polypropionates from a South China Sea Photosynthetic Mollusk: Isolation and Biomimetic Synthesis Highlighting Novel Rearrangements
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 页码: 9
作者:
Wu, Qihao
;
Li, Song-Wei
;
Xu, Heng
;
Wang, Hong
;
Hu, Pei
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/07/01
biomimetic synthesis
biosynthetic rearrangements
marine natural products
polyketides
Sacoglossan mollusk
Photothermal-reinforced and glutathione-triggered in Situ cascaded nanocatalytic therapy
期刊论文
JOURNAL OF CONTROLLED RELEASE, 2020, 卷号: 321, 页码: 734-743
作者:
An, Peijing
;
Fan, Fengying
;
Gu, Dihai
;
Gao, Zhiguo
;
Hossain, Abul Monsur Showkot
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2020/07/01
Nanocatalytic medicine
Synergistic therapy
Chemodynamic therapy
Photothermal-enhanced GSH depletion
GSH-triggered ROS generation
Ligand-induced activation of ERK1/2 signaling by constitutively active G(s)-coupled 5-HT receptors
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 9, 页码: 1157-1167
作者:
Liu, Ping
;
Yin, Yu-ling
;
Wang, Ting
;
Hou, Li
;
Wang, Xiao-xi
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
5-HT4R
5-HT6R
5-HT7AR
5-HT
ERK1/2
G(s)
beta-arrestin
Fyn
Src
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